Abstract
Effects of several doses (0.25, 0.5, 1, 5, and 10 mg/kg) of Δ9-tetrahydrocannabinol were tested on the response and reinforcement (food) in a schedule of differential reinforcement of low rates (DRL) in rats. The response frequency showed a trend to increase with the dose to its peak at 5 mg/kg and to decrease to below normal level at 10 mg/kg. The majority of the increases in response occurred during the first quadrant of the required time (40 sec), although distribution in other quadrants also occurred. The reinforcement decreased gradually with the increase of dose up to 10 mg/kg.
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Pradhan, S.N., Bailey, P.T. & Ghosh, P. Effects of Δ9-tetrahydrocannabinol on a timing behavior in rats. Psychon Sci 27, 179–181 (1972). https://doi.org/10.3758/BF03328931
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DOI: https://doi.org/10.3758/BF03328931