Abstract
Background
Evaluation of variations in pre- and postoperative patient reported outcomes (PRO) and the association between preoperative patient characteristics and health and satisfaction outcomes after total knee arthroplasty (TKA) may support shared decision-making in Germany. Since previous research on TKA health outcomes indicated valuation differences in longitudinal data, experienced-based population weights were used for the first time as an external valuation system to measure discrepancies between patient and average population valuation of HRQoL.
Methods
Baseline data (n = 203) included sociodemographic and clinical characteristics and PROs, measured by the EQ-5D-3 L and WOMAC. Six-month follow-up data (n = 161) included medical changes since hospital discharge, PROs and satisfaction. A multivariate linear regression analysis was performed to evaluate the relationship between preoperative patient characteristics and PRO scores. Patient acceptable symptom state (PASS) was calculated to provide a satisfaction threshold. Patient-reported health-related quality of life (HRQoL) valuations were compared with average experienced-based population values to detect changes in valuation.
Results
One hundred thirty-seven subjects met inclusion criteria. All PRO measures improved significantly. Preoperative WOMAC and EQ-5D VAS, housing situation, marital status, age and asthma were found to be predictors of postoperative outcomes. 73% of study participants valued their preoperative HRQoL higher than the general population valuation, indicating response shift. Preoperatively, patient-reported EQ-5D VAS was substantially higher than average experienced-based population values. Postoperatively, this difference declined sharply.
Approximately 61% of the patients reported satisfactory postoperative health, being mainly satisfied with results if postoperative WOMAC was ≥82.49 (change ≥20.25) and postoperative EQ-5D VAS was ≥75 (change ≥6).
Conclusion
On average, patients benefited from TKA. Preoperative WOMAC and EQ-5D VAS were predictors of postoperative outcomes after TKA. Particularly patients with high absolute preoperative PRO scores were more likely to remain unsatisfied. Therefore, outcome prediction can contribute to shared-decision making. Using general population valuations as a reference, this study underlined a discrepancy between population and patient valuation of HRQoL before, but not after surgery, thus indicating a potential temporary response shift before surgery.
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Background
Total knee arthroplasty (TKA) is a widely used surgical procedure [1, 2]. In 2014, Germany’s incidence of TKA was 197 per 100,000 inhabitants, which was the second highest rate in Europe [2]. While operation rates in Germany have stabilized at a high level, the rate of knee replacements worldwide continues to increase [2, 3]. Considering the increasing number of knee replacements and corresponding high costs [2, 3], knowledge about potential TKA outcomes is becoming increasingly important.
Although TKA is generally considered cost-effective [3, 4] and improved function, mobility and quality of life [1, 3, 5, 6], a subset of patients report prolonged pain, functional impairment [7] or remain dissatisfied with outcomes [8,9,10,11,12].
To better understand patients’ needs and reasons for poor outcomes regarding health and satisfaction, patient reported outcome (PRO) measures, such as health-related quality of life (HRQoL) or disease-specific measures, are highly relevant [13]. PROs support patients and clinicians in shared decision-making, which may improve outcomes [13] and could reduce costs [9]. Although there is evidence that preoperative patient characteristics [14,15,16] have an impact on HRQoL and satisfaction with surgery after TKA [17, 18], evidence in Germany is lacking.
Aside from measurable patient characteristics, psychological phenomena could influence HRQoL before and after TKA. Previous research comparing pre- and postsurgical TKA health outcomes showed changes in HRQoL valuation over time, which was termed response shift [19, 20]. Response shift describes the change of an individual’s internal standards of measurement (scale recalibration), values (reprioritization) or definition (reconceptualization) regarding a theoretical construct like HRQoL [21, 22]. Health issues, like illness, treatment or other life events, require adaptation of behavioral, cognitive and affective processes and subsequently cause a change in health state [21, 23]. Response shift may influence pre- and postoperative valuation of health states and thus, HRQoL change due to surgical treatment which may affect conclusions about treatment effects [23]. Therefore, response shift must be considered when analyzing surgical treatment outcomes.
The first aim of this paper is to identify the factors influencing patient-reported health and satisfaction outcomes after TKA among German patients. Thus, the association between preoperative patient characteristics and TKA outcomes is evaluated and a satisfaction threshold is calculated. Secondly, the paper assessed pre- and postoperative PRO variation and compared patient-reported HRQoL valuations with average population weights. These are used as an external valuation reference to identify eventual discrepancies between the patient’s valuation and this reference at different time points.
Material and methods
Study design and population
The study was conducted as a single-center cohort study recruiting TKA patients over 6 months at a teaching hospital with 365 beds in Munich, Germany. A total of 203 patients who had a TKA between January 2012 and June 2012 completed the preoperative health examination survey. Baseline data, including sociodemographic and clinical characteristics and PRO measures were assessed before TKA at hospital admission. Follow-up data, comprising medical changes since hospital discharge, PROs and satisfaction with TKA, were collected 6 months after hospital discharge between July 2012 and December 2012. All individuals who agreed with study participation were included. Patients were excluded from the analysis if they had a revision of TKA, a further operation of the operated knee or incomplete PRO data. The study was approved by the ethics commission of Klinikum rechts der Isar, Technical University Munich (ethical vote no. 5140/11). Informed consent was obtained from all participants included in the study.
Sociodemographic and clinical characteristics
Sociodemographic characteristics included age at operation, sex, marital status, housing situation and insurance status. Baseline clinical variables included height, weight, primary diagnosis, comorbidities, American Society of Anesthesiologists (ASA) Classification, Charlson Comorbidity Index, operations and procedures, type of arthroplasty (cemented or hybrid), number of operations on affected joint before TKA, preoperative and postoperative hemoglobin, number of transfused erythrocyte concentrates used, discharge type, and Knee Society Score. Follow-up data on newly diagnosed thrombosis, embolism, myocardial infarction, infection, further operations on affected joint or other relevant medical events were collected 6 months after discharge.
PROs
EQ-5D-3 L
Generic pre-and postoperative HRQoL was determined using the EQ-5D-3 L, which includes a descriptive part of five dimensions with three problem levels and a visual analogue scale (VAS), ranging from 0 (worst health state) to 100 (best health state), in which study participants evaluate their current health state [24]. Descriptive EQ-5D outcomes were weighted with the German experienced health state (EHS) EQ-5D value set. The German EHS-based value set is based on the general population’s valuation of their own health state and thus, should reflect patient-reported EQ-5D VAS [25]. This value set has been proven valid in chronic diseases, including hip arthroplasty [26, 27]. It was also shown to have better psychometric properties than a utility-based value set, to predict patients VAS and to also detect the impact of health shocks such as myocardial infarction on valuation response [28, 29]. The EHS-based index weights describe the average health state valuation in the general population. Given the above properties, it is used here as an external valuation reference. The population average valuations were compared with the patient-reported EQ-5D VAS, thus enabling detection of valuation changes.
WOMAC
To investigate patient reported knee-specific outcomes, the Western Ontario and McMaster Universities Arthritis (WOMAC) Index, a reliable and valid [30, 31] HRQoL measure to investigate knee-specific PROs, was used. The WOMAC index is calculated based on 24 questions regarding pain, stiffness and mobility [31]. We used a Likert scale version of the WOMAC score with answers ranging from 0 to 10. To facilitate comparison between different WOMAC dimensions and other outcomes, the scores were transformed to a 0 (worst) to 100 (best) scale, as recently recommended [32].
Satisfaction
Patient satisfaction was assessed 6 months after TKA using a 0 (not satisfied) to 10 (very satisfied) Likert scale. We defined a cut-off value of ≥9 as being satisfied, which is consistent with previous research [33].
Data analysis
Descriptive statistics of socioeconomic variables, clinical characteristics and preoperative, postoperative and change WOMAC and EQ-5D VAS scores (postoperative score minus preoperative score) were calculated. We addressed possible non-response bias by comparing responders in the follow-up measurement to non-responders, and included study participants to excluded participants, using Chi-squared and Fisher exact test (for variables with n < 5) for categorical data and Mann-Whitney U-test for continuous data. Correlation between EQ-5D VAS, EHS-based index and WOMAC index was analyzed using Pearson correlation coefficients ρ. Spearman rank correlation was computed to assess the association between postoperative and changes in EQ-5D VAS and WOMAC scores and satisfaction-score.
Patient acceptable symptom state (PASS) was calculated to identify absolute postoperative and changes in EQ-5D VAS and WOMAC cut-offs related to patient satisfaction with TKA. PASS is defined as the threshold beyond which patients consider themselves well [17, 34, 35]. To identify PASS, we used two different statistical approaches based on previous literature [33, 35]. First, a receiver operating characteristic (ROC) curve was plotted for postoperative WOMAC and EQ-5D VAS. PASS was estimated as EQ-5D VAS or WOMAC score that performed best with regard to Youden Index [36]. Secondly, we used the approach by Tubach et al. [35] to validate ROC curve results, which involved constructing a cumulative distribution function of satisfied patients and selecting the lowest EQ-5D VAS or WOMAC value that was achieved by 75% of satisfied study participants.
The strength of the relationship between preoperative patient characteristics and postoperative WOMAC and EQ-5D VAS scores was evaluated by conducting a multivariate linear regression analysis. Predictive variables were selected using stepwise selection (SLE = 0.3, SLS = 0.10), significance level was defined as α = 0.05. To rule out possible multicollinearity among predictive variables, we examined variance inflation factors (VIF) [37, 38]. To reveal discrepancies between the patient’s valuation and the average population reference, each before and after surgery, mean EQ-5D VAS scores were compared with mean EHS-based index values. Study subjects were then divided into four groups according to preoperative and postoperative difference between VAS and EHS-based value set and compared with regard to satisfaction with surgery, using a Chi-squared test. All data analyses were conducted with Microsoft Excel 2016 (Microsoft Corporation, Redmond; WA, USA) and SAS 9.4 (SAS Institute Inc., Cary, NC, USA).
Results
In total, 161 (79.31%) of 203 study participants completed the 6-months follow-up examination. Health characteristics and preoperative EQ-5D and WOMAC values did not significantly differ between patients who completed follow-up and those who were lost to follow-up. However, patients lost to follow-up were significantly younger (p = 0.04), and were less often discharged to inpatient rehabilitation (p = 0.02) (Additional file 1: Table S1). Of those who completed follow-up, 137 patients met our inclusion criteria and were analysed. Excluded study participants were more frequently females (p = 0.03), persons with compulsory insurance (p = 0.03), previous TKA (p = 0.02), and lower knee function score (p = 0.03) and were less often discharged to inpatient rehabilitation (p = 0.03; see Additional file 2: Table S2).
Health outcomes
Demographics and preoperative health characteristics of all study participants are presented in Table 1. Additional details about clinical characteristics are provided in Additional file 3: Table S3.
Average preoperative, postoperative and change in EQ-5D and WOMAC scores improved during the observation period (Table 2). The preoperative difference between EHS-based EQ-5D Index and EQ-5D VAS diminished postoperatively. Changes in individual EQ-5D dimensions are shown in Additional file 4: Table S4. Subjectively, approximately 4% of all participants described their health state as worse, 13% as similar, 30.5% as better and 48% as much better after TKA than before surgery (Additional file 5: Table S5).
Preoperative, postoperative and change EQ-5D VAS, EHS-based value set and WOMAC index were significantly correlated, except for postoperative VAS and preoperative WOMAC index and postoperative VAS and preoperative VAS.
After stepwise selection using all preoperative patient characteristics, the final multivariate regression model included age, marital status divorced, housing situation with family, WOMAC function score, Knee Society Score, EQ-5D VAS, Asthma and other arthroplasty (Table 3).
About 73% of patients rated their preoperative EQ-5D VAS higher than the EHS-based value set. Postoperatively this number decreased to about 62%. There was no significant association between pre- and postoperative difference between EQ-5D VAS and EHS-based value set and satisfaction (X2 = 4.60, df = 3, p = 0.2022) (Additional file 6: Table S6). A more detailed description of patient distribution regarding the difference between EQ-5D VAS and value set is shown in the appendix (Additional file 6: Table S6).
Satisfaction outcomes and PASS
Comparing changes in WOMAC and EQ-5D VAS to preoperative scores showed that patients with lower preoperative scores had higher absolute changes and reached change satisfaction thresholds more often (Additional file 9: Figure S1). Postoperatively, satisfied study participants had a higher mean change in WOMAC score of 32.7 than unsatisfied patients (mean change of 20.9). The mean change in EQ-5D VAS of satisfied patients was 14.6, but only 6.8 for unsatisfied patients. In total, almost 61% of all patients stated their postoperative health as satisfying.
Using Spearman’s rank correlation, we found a significant correlation between satisfaction and change in EQ-5D VAS (rs = .177, p = .039, n = 137), change in WOMAC index (rs = .298, p = .0004, n = 137), postoperative EQ-5D VAS (rs = .502, p < .0001, n = 137) and postoperative WOMAC scores (rs = .489, p = .0001, n = 137).
Both methods for calculating PASS yielded similar results. PASS as calculated based on ROC curves was 82.49 for postoperative WOMAC, 20.25 for change in WOMAC, 75 for postoperative EQ-5D VAS and 6 for change in EQ-5D VAS (Fig. 1).
PASS estimates, considering only satisfied patients, were 83.96 [95% CI 80.75–85.61] for postoperative WOMAC, 20.25 [95% CI 11.91–21.12] for WOMAC change, 72.00 [95% CI 70.00–76.00] for postoperative EQ-5D VAS and at least 0.00 [95% CI -6.00 – 6.00] for EQ-5D change (Fig. 2).
There was no significant difference in socio-demographic patient characteristics between satisfied and unsatisfied patients (Additional file 7: Table S7). However, patients who reached PASS change thresholds had average preoperative EQ-5D and WOMAC scores of 57.06 and 46.04 respectively compared to 77.65 and 65.12 for patients who did not reach PASS thresholds. The average preoperative EQ-5D and WOMAC scores of patients who reached postoperative PASS thresholds were 64.87 and 56.74, while patients who remained unsatisfied had average scores of 58.48 and 47.46.
Discussion
The evaluation of pre- and postoperative PRO variation and the association between preoperative patient characteristics and health and satisfaction outcomes in TKA patients in Germany revealed several interesting results. All PRO measures improved significantly. Preoperative WOMAC and EQ-5D VAS, housing situation, marital status, age and asthma were found to be predictors of postoperative outcomes. 73% of study participants valued their preoperative HRQoL higher than the general population valuation. Preoperatively, patient-reported EQ-5D VAS was substantially higher than average experienced-based population values. Postoperatively, this difference declined sharply. Approximately 61% stated their postoperative health as satisfying, being mainly satisfied with results if postoperative WOMAC was ≥82.49 (change ≥20.25) and postoperative EQ-5D VAS was ≥75 (change ≥6).
Preoperative patient characteristics and health outcomes
Mean WOMAC and EQ-5D improved 6 months after TKA, supporting previous research findings [14, 17, 39, 40]. However, 4% of all participants described their health state as worse and 13% as similar.
Multivariate analysis of determinants of PRO change indicated that marital status “divorced” had a negative impact on WOMAC change while living with family had a positive impact on change of WOMAC and EQ-5D VAS. This is consistent with previous research showing social support to positively affect outcomes in patients with joint replacement surgery [41, 42]. Furthermore, our results corroborated findings of other studies that age does not negatively affect TKA outcomes [6, 14]. However, the effect of age on TKA outcomes is controversially discussed [43, 44]. Our findings that higher preoperative PRO scores predicted lower change in PROs also confirm earlier research results of total joint arthroplasty patients [33, 39].
Comparison of patient-reported EQ-5D VAS and EHS-based population valuation
The difference between patient-reported EQ-5D VAS and EHS-based valuation, particularly for preoperative values was interesting. On average, patients in our study sample overrated their preoperative health state compared to the general German population. This difference diminished substantially postoperatively. Previous research in TKA patients found different HRQoL value decrements for the same health problems pre- and postoperatively indicating response shift. Postoperative value decrements were larger in all reported studies [19, 45, 46]. As the German EHS-based value set has been shown to be a good prediction for HRQoL valuation [28, 29] we assume that the valuation differences indicate eventual response shift. Using external valuations as a reference could therefore be a new methodological approach to identify possible response shift.
Pickard et al. [45] hypothesized that larger HRQoL value decrements are a possible result of dissatisfaction with surgery results. Our study results did not support this conclusion as we did not find a significant relation between satisfaction and differences between pre- and postoperative EQ-5D VAS and EHS-based value sets according to a Chi-squared test (Additional file 6: Table S6). Razmjou et al. [20] and Zhang et al. [19] demonstrated that TKA patients preoperatively judged themselves better than they did when asked again postoperatively. However, these study results were based on the then-test method, which is susceptible to recall bias [47]. Our study results also indicate response shift preoperatively, as the difference between the average patient-reported EQ-5D VAS and EHS-based index weights decreased postoperatively, supporting previous research results. Response shift in terms of preoperative valuation discrepancy between patient’s valuation and average population valuation leads to smaller effects of surgery. An important question for future research is whether, and if so, when, valuation changes have taken place prior to TKA and hospital admission.
An additional regression analysis on the impact of the difference between patient-reported EQ-5D VAS and EHS-based valuation on postoperative WOMAC sum indicated that high patient-reported values compared to average population values correlate positively with knee specific outcomes (Additional file 8: Table S8). If relatively high, pre-operative VAS reports by patients would be interpreted as a sign of optimism, this result would resemble improved outcomes found for optimistic patients after hip replacement [48].
Satisfaction outcomes and PASS
Approximately 61% of the study population were subjectively satisfied with TKA surgery results. Satisfaction rates found in previous research on TKA surgery were often higher, yet these are not directly comparable because of different examination methods or definition of satisfaction [17, 49]. PASS thresholds of this study confirmed findings of previous research [50], although other studies analyzed other PRO measures [49] or subscales instead of overall scores [51, 52]. Regarding PASS thresholds, we found a difference between preoperative EQ-5D (57.06) and WOMAC (46.04) scores in patients who reached the threshold compared to those not reaching the threshold (preoperative EQ-5D: 77.65, WOMAC: 65.12), which indicates that patients with particularly high preoperative PRO scores are more likely to remain unsatisfied after TKA. This insight and the link of PASS thresholds to preoperative PRO scores in general may support clinicians and patients in decision-making and could therefore potentially contribute to shared-decision making and patient-centered care. Satisfaction was significantly associated with change of EQ-5D VAS, change of WOMAC index, postoperative EQ-5D VAS and postoperative WOMAC scores. Although the associations are weak, our results on the role of satisfaction correspond to previous research [53, 54].
Strengths and limitations
To the best of our knowledge, this is the first study to use a combination of the WOMAC as a knee-specific PRO measure and the generic EQ-5D-3 L to analyse the impact of preoperative patient characteristics on postoperative TKA outcomes and associated PASS thresholds in Germany. Furthermore, the present study adds to the literature by comparing preoperative and postoperative patient-reported EQ-5D VAS and EHS-based population valuation weights to detect discrepancies between patient-valued and average population-valued HRQoL, potentially providing a new methodological approach to detect response shift. A further strength of this study is the breadth of preoperative patient characteristics taken into account.
We are aware that our study has several limitations, including the small sample size and the involvement of just one hospital center for patient acquisition. Accordingly, the results may not be representative for the general German population. For generalization of the results, multicenter research with a larger sample size is needed. Another limitation of this study may be the short follow-up of 6 months. Although previous research found the greatest improvements after TKA in the first 3 months [14], pain, function, mobility, and HRQoL continue to improve up to 12 months postoperatively [14, 16, 17]. There is inconsistent evidence if there is a clinically important improvement in the six to 12 months follow-up period after TKA [55]. To allow for long-term outcome prediction a second follow-up period after 12 months or later should be included in upcoming research projects.
Furthermore, the significant differences in age, health insurance and type of discharge between the study population and lost-to follow up patients may have influenced the reported results. While we considered a large range of socio-economic variables, additional variables would have been useful to detect a potential impact of education and income on health and quality of life outcomes. In addition, we could not account for the impact of different postoperative rehabilitation programs on postoperative outcomes. Importantly, as there are no evidence-based rehabilitation guidelines for TKA patients in Germany [56], follow-up treatments might have an impact on postoperative outcomes. Owing to the lack of a comparison with well-established response shift methodologies such as Oorts’s structural equation modeling [57,58,59] our results only provide an indication of response shift while an explanation by response shift would require further research. Furthermore, our study results do not contain any information about the different components of response shift.
Another limitation could be the cut-off defining satisfied and not satisfied patients as different cut-offs could affect the proportion of satisfied patients. Previous research only found that cut-off definition had only a small impact on PASS calculations of satisfied patients [33, 49]. Furthermore, we did not calculate PASS subgroup values for different preoperative health states due to the small sample size. Since results of both calculating methods were similar, we expect our WOMAC and EQ-5D VAS PASS estimates to be robust. Future research should include PASS calculation for subgroups.
Conclusion
On average, patients benefited from TKA and improved in pain, stiffness, function and overall HRQoL. Preoperative WOMAC and EQ-5D VAS were predictors of postoperative outcomes after TKA and social support seems to contribute to health outcomes. PASS calculations suggested that patients with particularly high preoperative PRO scores were more likely to remain unsatisfied after TKA. Outcome prediction, based on identifying the impact of preoperative patient characteristics on health and satisfaction outcomes, can contribute to shared-decision making and may help to create realistic expectations, consequently affecting HRQoL and satisfaction outcomes after TKA. Future research projects with longer follow-up periods are needed to better account for respective outcome prediction.
Using general population valuations as a reference, a discrepancy to patient valuations was only seen before but not after surgery, thus indicating response shift prior to surgery. The change in discrepancy between patient and reference valuation of HRQoL affects the size of treatment effect and thus potentially conclusions building upon this. Further research is needed for more detailed explanation. To evaluate the validity of the methodology of comparing patient-reported HRQoL values and EHS-based population weights to detect and quantify response shift, future research should directly compare the results of this approach with established response shift methodologies. PRO data should be collected earlier to take account of the influence of preoperative events which could be response shift catalysts before TKA and hospital admission.
Availability of data and materials
The dataset analysed during the current study is not publicly available because patient consent in this study did not include provision of data for public file sharing.
Abbreviations
- ASA:
-
American Society of Anesthesiologists
- EHS:
-
Experienced health state
- EQ-5D:
-
EuroQol five dimension
- HRQoL:
-
Health-related quality of life
- PASS:
-
Patient acceptable symptom state
- ROC:
-
Receiver operating characteristic
- TKA:
-
Total knee arthroplasty
- VAS:
-
Visual analogue scale
- VIF:
-
Variance inflation factors
- WOMAC:
-
Western Ontario and McMaster Universities Arthritis
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Acknowledgments
The cooperation underlying this study has been supported by “Munich Network Health Care Research – MobilE-Net” (grant number 01GY1603A, German Federal Ministry of Education and Research).
The authors are grateful to Dr. Reneé Stark MD FRCP (C) MPH for her substantial, detailed comments on an earlier version of this paper.
Informed consent
Informed consent was obtained from all individual participants included in the study. Patient consent in this study did not include provision of data for public file sharing.
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Authors and Affiliations
Contributions
JF and CB conceived the study design and drafted, analysed and interpreted the manuscript. RL supervised and directed the study, contributed to data interpretation and drafting of the manuscript. MV and WP contributed to the conception of the study and PB and WP added clinical input. All authors reviewed the manuscript and approved the final manuscript to be published.
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Ethics approval and consent to participate
The study was approved by the ethics commission of Klinikum rechts der Isar, Technical University Munich. All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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The authors declare that they have no competing interests.
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Supplementary information
Additional file 1: Table S1.
Comparison of patients with completed follow-up (‘responders’) and lost to follow-up (‘non-responders’).
Additional file 2: Table S2.
Comparison of included and excluded study participants.
Additional file 3: Table S3.
Detailed descriptive statistics and preoperative clinical characteristics (n > 5) of study population.
Additional file 4: Table S4.
Changes in EQ-5D dimensions (n).
Additional file 5: Table S5.
Time until effect on health state, pain and mobility and general effect after 6 months.
Additional file 6: Table S6.
Detailed description of patient distribution regarding the difference between EQ-5D VAS and value set and satisfaction.
Additional file 7: Table S7.
Comparison of satisfied and not satisfied patients.
Additional file 8: Table S8.
Linear regression model predicting postoperative WOMAC Sum.
Additional file 9: Figure S1.
Scatterplots of WOMAC sum/EQ-5D VAS change/postoperative scores by preoperative scores, grouped by patient satisfaction.
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Felix, J., Becker, C., Vogl, M. et al. Patient characteristics and valuation changes impact quality of life and satisfaction in total knee arthroplasty – results from a German prospective cohort study. Health Qual Life Outcomes 17, 180 (2019). https://doi.org/10.1186/s12955-019-1237-3
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DOI: https://doi.org/10.1186/s12955-019-1237-3