Abstract
Using Fura-2AM microfluorimetry, we have shown for the first time that 5-lipoxygenase specific inhibitor antiasthmatic agent zileuton significantly inhibits Ca2+-responses induced by glutoxim and molixan in macrophages. The results support 5-lipoxygenase involvement in the effect of glutoxim and molixan on intracellular Ca2+ concentration in macrophages and indicate the inadvisability of a combined use of drugs glutoxim and molixan and antiasthmatic agent zileuton.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Borisov, A.E., Kozhemyakin, L.A., Antushevich, A.E., et al., Vestn. Hirurgii im. I.I. Grekova, 2001, vol. 4, pp. 32–38.
Kurilova, L.S., Krutetskaya, Z.I., Lebedev, O.E., et al., Cell Tissue Biol., 2008, vol. 2, pp. 322–332.
Kurilova, L.S., Krutetskaya, Z.I., Lebedev, O.E., et al., Tsitologiya, 2011, vol. 53, no. 9, p.708.
Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A., et al., Dokl. Biochem. Biophys., 2015, vol. 465, pp. 374–376.
Krutetskaya, Z.I., Kurilova, L.S., Antonov, V.G., et al., Dokl. Biol. Sci., 2013, vol. 452, pp. 277–279.
Milenina, L.S., Krutetskaya, Z.I., Naumova, A.A., et al., Tsitologiya, 2015, vol. 57, no. 7, pp. 518–525.
Khanapure, S.P., Garvey, D.S., Janero, D.R., et al., Curr. Top. Med. Chem., 2007, vol. 7, pp. 311–340.
Montuschi, P., Pharmaceuticals, 2010, vol. 3, pp. 1792–1811.
Wenzel, S.E. and Kamada, A.K., Ann. Pharmacother., 1996, vol. 30, pp. 858–864.
Berger, W., De Chandt, M.T.M., and Cairns, C.B., Int. J. Clin. Pract., 2007, vol. 61, pp. 663–676.
Zouboulis, C.C., Dermatoendocrinology, 2009, vol. 1, pp. 188–192.
Grynkiewicz, G., Poenie, M., and Tsien, R.Y.., J. Biol. Chem., 1985, vol. 260, pp. 3440–3450.
Xie, Q., Zhang, Y., Zhai, C., et al., J. Biol. Chem., 2002, vol. 277, pp. 16559–16566.
Di Capite, J., Shirley, A., Nelson, C., et al., FASEB J., 2009, vol. 23, pp. 894–905.
Di Capite, J., Nelson, C., Bates, G., et al., J. Allergy Clin. Immunol., 2009, vol. 124, pp. 1014–1021.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © Z.I. Krutetskaya, L.S. Milenina, A.A. Naumova, V.G. Antonov, A.D. Nozdrachev, 2016, published in Doklady Akademii Nauk, 2016, Vol. 469, No. 5, pp. 635–637.
Rights and permissions
About this article
Cite this article
Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. 5-Lipoxygenase inhibitor zileuton inhibits Ca2+-responses induced by glutoxim and molixan in macrophages. Dokl Biochem Biophys 469, 302–304 (2016). https://doi.org/10.1134/S1607672916040177
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1607672916040177