Abstract
Biological and mathematical grounding was provided for the mechanism that is responsible for the optical radiation-dependent regulation of the human circadian rhythm that involves the well-known retinal photoreceptors, rods and blue-sensitive cones. It was shown that light-sensitive retinal ganglion cells are unable to act as receivers of optical radiation. Two spectral channels involved in regulating the circadian rhythm were observed in the retino-hypothalamic pathway. An analytical expression for the function of the relative spectral circadian efficiency was obtained for Scalculations and mathematical modeling of the human circadian rhythm.
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Abbreviations
- ipRGC:
-
intrinsically photoreceptive retinal ganglion cell
- RCSEF:
-
relative circadian spectral efficiency function
References
G. C. Brainard and G. L. Glickman, CIE 152, 1 (2003).
G. C. Brainard and G. L. Glickman, Svetotekhnika No. 1 (2004).
K. Thapan, J. Arendt, and D. J. Skene, J. Physiol. 535, 261 (2001).
R. G. Foster, I. Provencio, D. Hudson, et al., J. Comp. Physiol. A 169, 39 (1991).
M. S. Freedman, R. J. Lucas, B. Soni, et al., Science 284, 502 (1999).
C. A. Czeisler, T. L. Shanahan, E. B. Klerman, et al., N. Engl. J. Med. 332, 6 (1995).
E. B. Klerman, T. L. Shanahan, D. J. Brotman, et al., J. Biol. Rhythms 17, 548 (2002).
G. C. Brainard and I. Provencio, in Proc. 2nd CIE Expert Symposium on Lighting and Health (CIE 031) (Vienna, 2006), pp. 6–21.
I. Provencio, G. Jiang, W. J. De Grip, et al., Proc. Natl. Acad. Sci. U. S. A. 95, 340 (1998).
I. Provencio, I. R. Rodriguez, G. Jiang, et al., J. Neurosci. 20, 600 (2000).
J. J. Gooley, J. Lu, T. C. Chou, et al., Nat. Neurosci. 4, 1165 (2001).
D. M. Berson, F. A. Dunn, and M. Takao, Science 295, 1070 (2002).
S. Hattar, H.-W. Liao, M. Takao, et al., Science 295, 1065 (2002).
L. P. Morin, J. H. Blanchard, and I Provencio, J. Comp. Neurol. 465, 401 (2003).
P. J. Sollars, C. A. Smeraski, J. D. Kaufman, et al., Vis. Neurosci. 20, 601 (2003).
G. C. Brainard, J. P. Hanifin, J. M. Greeson, et al., J. Neurosci. 21, 6405 (2001).
V. V. Meshkov and A. B. Matveev, Foundations of Lighting Engineering, Part 2: Physiological Optics and Colorimetry, 2nd ed. (Energoatomizdat, Moscow, 1989) [in Russian].
S. V. Kravkov, The Eye and Its Functioning (USSR Acad. Sci., Moscow—Leningrad, 1950) [in Russian].
V. Adrian, Svetotekhnika No. 1 (2009).
P. Berge, Y. Pomeau, and C. Vidal, L’ordre dans le chaos (Hermann, Editeurs des sciences et des arts, 1988).
F. Bloom, A. Lazerson, and L. Hofstadter, Brain, Mind, and Behavior (W. H. Freeman, New York, 1984; Mir, Moscow, 1988).
E. G. Pestov and G. M. Lapshin, Quantum Electronics (Voenizdat, Moscow, 1972) [in Russian].
R. M. Gagliardi and Sh. Karp, Optical Communications (Wiley, 1976; Scyaz’, Moscow, 1978).
Quantum Optics and Radiophysics: Lectures in Summer School on Theoretical Physics, Les Houches, France, Ed. by O. V. Bogdankevich and O. N. Krokhin (Mir, Moscow, 1966) [in Russian].
V. M. Fain and Ya. I. Khanin, Quantum Radiophysics (Sovetskoe Radio, Moscow, 1965) [in Russian].
B. R. Levin and V. Schwarz, Probabilistic Models and Methods in Communications and Control Systems (The Statistical Theory of Communications, Vol. 24) (Radio i Svyaz’, Moscow, 1985) [ in Russian].
V. D. Glezer, Sight and Mind (Nauka, Leningrad, 1985) [in Russian].
F. B. Kogan, N. P. Naumov, V. G. Rezhabek, and O. G. Chorayan, Biological Cybernetics (Vysshaya Shkola, Moscow, 1972) [in Russian].
Yu. A. Trifonov, in Sensory Systems: Vision (Nauka, Leningrad, 1982) [in Russian].
A. V. Leonidov, Svetotekhnika No. 5, 49 (2010).
I. Abramov and J. Gordon, J. Optic. Soc. Am. 67 (2), 202 (1977).
B. Stabell and U. Stabell, J. Optic. Soc. Am. 70 (6), 706 (1980).
B. Stabell and U. Stabell J. Optic. Soc. Am. 71, 841 (1981).
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Original Russian Text © A.V. Leonidov, 2016, published in Biofizika, 2016, Vol. 61, No. 6, pp. 1208–1218.
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Leonidov, A.V. On optical receivers in the pathway implicated in regulating the human circadian rhythm. BIOPHYSICS 61, 1002–1010 (2016). https://doi.org/10.1134/S0006350916060117
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DOI: https://doi.org/10.1134/S0006350916060117