Abstract
To evaluate the impact of using ion-releasing liners on the 3-year clinical performance of posterior resin composite restorations after selective caries excavation with polymer burs. 20 patients were enrolled in this trial. Each patient had two deep carious lesions, one on each side of the mouth. After selective caries removal using polymer bur (PolyBur P1, Komet, Brasseler GmbH Co. KG, Lemgo, Germany), cavities were lined with bioactive ionic resin composite (Activa Bioactive Base/Liner, Pulpdent, Watertown, MA, USA) or resin-modified glass ionomer liner (Riva Light Cure, SDI, Bayswater, Victoria, Australia). All cavities were then restored with nanofilled resin composite (Filtek Z350XT, 3M Oral Care, St. Paul, MN, USA). All the tested materials were placed according to the manufacturers’ instructions. Clinical evaluation was accomplished using World Dental Federation (FDI) criteria at baseline and after 6 months, 1, 2, and 3 years. Data were analyzed using Mann–whitney U and Friedman tests (p < 0.05). The success rates were 100% for all resin composite restorations either lined with ion-releasing resin composite or resin-modified glass ionomer liner. Mann–whitney U test revealed that there were no statistically significant differences between both ion-releasing lining material groups for all criteria during the follow-up periods (p > 0.05). Resin composite restorations showed acceptable clinical performance over 3 years either lined with bioactive ionic or resin-modified glass ionomer liners after selective caries excavation preserving pulp vitality. After the 3-year follow-up period, Activa Bioactive and Riva Light Cure liners were clinically effective and they exhibited with the overlying composite restorations successful clinical performance.
Trial registration number: NCT05470959. Date of registration: 22/7/2022. Retrospectively registered.
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Introduction
Dental caries remains the most prevailing global disease that has a deleterious effect on the oral health among adults1,2,3. Managing deep carious lesions still represents a great challenge in determining the best treatment option that provides optimum prognosis through retaining pulp vitality and preventing apical lesions4. The traditional management was based upon non-selective caries removal to hard dentin strategy including complete removal of all infected and affected dentin to preclude further cariogenic activity offering well-mineralized dentin5. However, complete caries excavation frequently results in pulp exposures and weakening of tooth structure which compromises the success of dental treatment6. Therefore, less invasive alternative approaches have been adopted. One of these approaches is selective caries excavation which aims to remove the outer infected dentin layer, while maintaining the deeper remineralizeable affected layer7. A previously conducted systematic review3 confirmed that selective caries removal was an effective method for conservative excavation of deep carious lesions in permanent teeth.
The rapid development of the concurrent cariology concepts and the advances in dental materials have brought new techniques to the dental field in order to minimize the unnecessary sacrifice of tooth substrate8. Self-limiting polymer burs were released to dental market with slightly inferior mechanical properties than sound dentin. Their blades were designed to remove infected dentin by locally depressing the soft carious tissue and pushing it forward along the surface until it ruptures and carried out of the cavity9,10. When these burs touch sound or caries-affected dentin, they become dull and produce vibrations making further cutting impossible11. Toledano et al.12 reported that polymer burs showed higher preservation of affected dentin after deep caries excavation when compared to carbide burs. Another in-vitro study13 confirmed that polymer burs were as effective as tungsten carbide burs in dentin caries excavation.
Pulp protection using cavity liners is a crucial step in managing deep carious lesions. These intermediary liners exhibit several advantages such as antibacterial property, remineralization potential, thermal/electric insulation, and they act as chemical barriers protecting the pulp14. Qureshi et al.15 reported that the ideal cavity lining material should promote reparative dentin formation, preserve pulp vitality, release fluoride, attach to restorative materials, and inhibit bacterial leakage. Previously, calcium hydroxide was the most commonly used liner during step-wise excavation method14. However, a systematic review16 reported failure of calcium hydroxide lining material in incompletely excavated teeth due to over-time degradation, inferior mechanical properties, and difficulties in dentin barrier formation17. Nowadays, several promising ion-releasing lining materials have replaced calcium hydroxide such as resin-modified glass ionomer liners (RMGI)18. RMGIs were introduced as an attempt to overcome the drawbacks of their conventional predecessors, while maintaining the clinical advantages of fluoride release and antibacterial activity. Moreover, they offer enhanced physical properties, controllable working time, less moisture sensitivity, and stable bonding to tooth structure due to micromechanical adhesion19.
A new lining material called Activa Bioactive was launched in 2014. The manufacturer claims that this material exhibits improved strength, esthetics and good physical properties. Also, it show high ability for calcium, phosphate, and fluoride release which stimulates the remineralization and apatite formation as claimed by the manufacturer18. These intermediatory materials showed similarity with natural dentin from physical and chemical aspects. This similarity is attributed to their ionic resin matrix, shock-absorbing resinous component, as well as, bioactive filler ingredient20. The manufacturer also claimed that this material does not require additional pretreatment before application due to its self-adhesive property and chemical bonding to tooth structure. A 1-year follow-up randomized clinical trial reported that Activa Bioactive liner showed high clinical and radiographic success rates and could be used safely in indirect pulp treatment21.
To date and according to the authors’ knowledge, Activa Bioactive liner has scant literature comparing its effect to other lining materials in deep cavities after selective caries excavation. Moreover, no randomized clinical trials evaluating the long-term clinical success of posterior resin composite restorations lined with this new material using all the FDI criteria were found. The authors believe that RMGI lining material could be also considered as an ion-releasing intermediary material. Hence, this clinical study was designed to comprehensively evaluate the impact of using ion-releasing liners on the 3-year clinical performance of posterior resin composite restorations after selective caries excavation with polymer burs using the FDI evaluation criteria. The primary clinical outcome was the clinical success rate of composite restorations after 3 years, while the esthetic, functional, and biological clinical criteria were also evaluated as secondary outcomes. The null hypothesis tested was that there would be no significant difference in the clinical outcome of posterior resin composite restorations lined with Activa Bioactive or Riva Light Cure liners.
Materials and methods
Ethical approval and trial registration
This clinical trial was approved by the Dental Research Ethics Committee of Mansoura University (approval no. M19091019). The selected volunteers were participated in this trial after signing a consent which guaranteed their confidentiality and informed them about steps, duration, place, benefits, and possible side effects of the research. This trial was registered at https://www.clinicaltrials.gov under a registration number (NCT05470959).
Trial design and blinding
This was a randomized clinical trial along with split mouth design. It was executed following guidelines and recommendations of World Dental Federation (FDI)22,23 and Consolidated Standards of Reporting Trials (CONSORT)24. Neither the patients nor the evaluators knew which lining material was used, thus resulting in a double-blind study (Fig. 1).
Sample size calculation
The primary outcome of this cohort RCT was the clinical success rate of composite restorations after 3 years, considering all properties evaluated. The sample size was calculated on the basis of the clinical success rate of posterior composite restorations observed in a previous study14, testing resin-modified glass ionomer liner after selective/partial caries removal with a success rate of 97% after 12 months using statistical software program (G*Power, Ver.3.1.9.1, Dusseldorf, Germany) at 95% confidence level with a statistical power of 80% and a significance level (alpha value = 5%). Therefore, a representative sample composed of 20 teeth had to be included in each treatment group taking into consideration the possible patient dropout during the trial period.
Randomization
Each selected patient received dental treatment for deep carious lesions using two different pulp lining material. Each material was placed in a different side of mouth randomly as determined by flipping a coin25. A staff member not involved in the clinical trial performed the randomization process and the allocation assignment was revealed only on the day of the restorative procedure in order to avoid the bias.
Recruitment and eligibility criteria
20 patients were selected from regular attendants of Operative Dental Clinic at the Faculty of Dentistry, Mansoura University, Egypt. The average age of patients involved in this study was 25 years (range, 20–35 years).
Inclusion criteria were as follows: a patient presenting with (1) a need for at least two deep carious lesions (ICDAS 5 or 6) one on each side of the mouth, (2) symptomless and vital teeth with no signs for pulpal inflammation or pathological lesions, (3) good oral hygiene, and (4) good likelihood of recall availability. Exclusion criteria were as follows: (1) adverse medical history, allergies or systemic diseases, (2) pregnant or lactating females, (3) visibly cracked teeth, (4) sensitivity to percussion, and (5) severe or chronic periodontal problems14,26.
Clinical procedures
The lining materials used in this study were: Bioactive ionic resin composite; Activa Bioactive (Pulpdent, Watertown, MA, USA) and Riva Light Cure (SDI, Bayswater, Victoria, Australia). A nanofilled resin composite; Filtek Z350XT (3M Oral Care, St. Paul, MN, USA) was used as a final restoration. The materials used in this clinical study are listed in Table 1. All these materials were used in accordance with the manufacturers’ instructions. One experienced dentist performed the clinical procedures in 20 patients (11 male and 9 female) fulfilling the inclusion and exclusion criteria.
Preoperative digital photographs were taken as part of dental screening. To detect the depth of the carious lesions, bitewing radiographs were examined using the common classification system that consists of E0 (no lesion), E1 (lesion within the outer half of enamel), E2 (lesion within the inner half of enamel), D1 (lesion within the outer third of dentin), D2 (lesion within the middle third of dentin), and D3 (lesion within the inner third of dentin)27,28. After assessing all radiographs under optimal light conditions, the depth of proximal carious lesions in all cases was D3. Pulp vitality was confirmed by application of cold dry ice29. Dental plaque and salivary pellicle were removed from teeth surface by using pumice-water slurry and rubber cup14.
After receiving local anesthesia and rubber dam application, cavity preparation started by removing carious tissue using diamond round and straight fissure instruments (801.314.012 & 835KR. 314.014, Komet, Brasseler, Lemgo, Germany) at high-speed handpiece (Sirona T3, Bensheim, Germany) under copious air–water cooling. Deep carious lesions on pulpal and axial walls were managed by selective caries excavation using polymer bur PolyBur P1 (Komet, Brasseler GmbH Co. KG, Lemgo, Germany) at low-speed hand-piece with circular movements starting from the center of the lesion to the periphery. The caries excavation stopped when polymer burs reached caries-affected dentin as they became abraded or blunted with no further ability to remove tissue30. The cavity depth was evaluated using Prepometer (Hager & Werken, Duisburg, Germany). The prepared cavities were then finished using extra-fine diamond instrument (835 KREF.314.012, Komet) in order to round all line angles.
After cavity preparation, each patient received both lining material; Activa Bioactive and Riva Light Cure. These materials were placed only over the pulpal portion of preparations. Regarding Activa Bioactive, the material was applied directly to pulpal floor without placement of any additional pretreatment as recommended by the manufacturer, and then light cured for 20 s by using a light emitting diode (LED) curing unit Elipar S10 (3M Oral Care, St. Paul, MN, USA) which had a wave length between 430 and 480 nm and a light intensity 1200 mW/cm2. For cavities receiving Riva Light Cure, dentin was conditioned with 25–30% polyacrylic acid (Riva Conditioner, SDI Bayswater, Victoria, Australia) for 10 s, then rinsed thoroughly with water and gently dried with oil-free air without desiccating the surface keeping dentin moist. Riva Light Cure was then applied and light cured for 20 s.
Following lining material placement, selective enamel etching was performed by application of 34% phosphoric acid gel (Scotchbond Etchant, 3M Oral Care, St Paul, MN, USA) on the enamel margins of prepared cavities for 15 s. The preparation was then thoroughly rinsed by water for 10 s and gently air dried. The universal bonding agent (Single Bond Universal, 3M Oral Care, St. Paul, MN, USA) was rubbed on the etched enamel and dentin surface by microbrush for 20 s. To evaporate the solvent, the bonding agent was gently air dried for 5 s followed by light curing for 10 s. Filtek Z350XT nanofilled resin composite (3M Oral Care, St. Paul, MN, USA) was applied incrementally to the prepared cavities using gold plated instrument. Each increment (2 mm thickness) was obliquely placed and light cured for 20 s. For restoring Class II cavities, a sectional coated metal matrix band with a ring and plastic wedge (Palodent, Dentsply DeTrey, konstanz, Germany) was used26. The occlusion was checked using articulating paper (Swedish Dental Supplies Ab, Akarp, Sweden) for establishing proper occlusal morphology and contact. The restorations were finished by using a high-speed diamond finishing instruments (4092.314, Komet) under copious air–water cooling. Polishing was performed using composite polishing kit (Shofu Inc, Kyoto, Japan) and Sof-lex discs (3M Oral Care, ST. Paul, MN, USA). The clinical procedures are presented in Figs. 2 and 3.
Clinical evaluation
All restorations were evaluated clinically at baseline (1 week after the placement of restorations) and after 6 months, 1, 2 and 3 years according to FDI criteria. The clinical outcomes were evaluated according to the criteria in the following scores: (clinically very good, clinically good, clinically sufficient/satisfactory, clinically unsatisfactory, and clinically poor)22,23.
The evaluation process was carried out by two independent calibrated examiners who were blinded to the tested lining materials and did not contribute in the restoration process. The inter-examiner agreement was measured using Cohen’s Kappa coefficient. Disagreement occurred throughout evaluation process was solved by reevaluating the restorations by both examiners and obtaining a consensus before the patients left31. At the beginning of the assessment, each patient was instructed to brush his/her teeth for 3 min in order to remove dental plaque and food debris. The occlusal surface of the restoration was then dried with gentle air stream. A magnifying loupe was used as an additional diagnostic tool to assess in the visual examination of the restorations beside the standard illumination of the dental unit to ensure the validity of results32. All the FDI criteria were used for evaluating the lining materials and restorations. All the evaluation methods are illustrated in Table 2.
Statistical analysis
The study outcomes were tabularized, coded, and analyzed using Statistical Software Package Program (IBM-SPSS, V.26, Armonk, NY, USA). The normality of data was checked by Kolmogorov–Smirnov test. Since the data did not follow normal distribution pattern, the descriptive statistics were exhibited in the form of median, minimum, and maximum range. Non-parametric statistical procedures were utilized to test significance of difference for each criterion at a significance level of p < 0.05. Mann–whitney U test was used to statistically compare between the data of the two tested groups for every criterion in each follow-up period. Moreover, Friedman test was used to statistically compare between the data of the same group for every criterion throughout the different follow-up periods.
Ethical approval
The current study was registered on clinical trials with a unique identification number (I.D. NCT05470959). Ethical approval was obtained before the start of the study. The study was approved by the Dental Research Ethics Committee of Mansoura University (approval no. M19091019). The procedures used in this study adhere to the tenets of Helsinki Declaration.
Informed consent
All participants gave their informed consent prior to their inclusion in the study.
Results
The patient’s recall rate was 100% at baseline and 95% at the remaining follow-up evaluations. The reason of the patient’s dropout was travelling abroad during the study. The demographic data and clinical characteristics of each group are presented in Table 3. The Cohen’s Kappa statistics showed strong inter-examiner agreement (Kappa = 0.90), and no statistically significant difference was observed in patients’ answers (p > 0.05). The results of the current clinical trial are illustrated in Tables 4 and 5.
The success rate for both groups was 100% after 3 years (Figs. 4 and 5). The scores of clinical evaluations for the current study showed no statistically significant differences between the two tested groups at baseline and after 6 months, 1, 2, and 3 years (p > 0.05). Also, no significant changes over time were detected for both groups for any of the evaluation criteria (p > 0.05). Radiographic examination using digital periapical radiograph showed that there were no pathological changes related to any restoration lined neither with Activa Bioactive nor Riva Light Cure after 3 years (Fig. 6).
Discussion
The current clinical trial investigated the 3-year performance of posterior resin composite restorations lined with Activa Bioactive and Riva Light Cure after selective excavation of deep carious lesions. The study results showed that there was no statistically significant difference between both groups by the end of 3-year follow-up. Therefore, the null hypothesis formulated at the beginning of this clinical trial was accepted.
Laboratory studies participate in initial assessment of dental materials providing valuable data regarding their potential performance. However, this does not precisely reveal their clinical performance due to the presence of variable parameters in oral cavity including hydrolytic attacks, pH variations, and temperature changes33,34. Therefore, clinical trials are usually considered the preferable method for evaluating the clinical performance and longevity of newly developed dental materials25. Split-mouth design was chosen for within-patient comparisons rather than between-patient comparisons aiming to expose all of the tested materials to the same oral environmental conditions35. The present clinical study was a double-blinded study in order to eliminate examiner or patient related bias25.
The removal of caries-infected dentin without affecting remineralizable dentin has been the ultimate goal of minimal invasive dentistry30. Polymer burs were used in the current study due to their self-limiting ability in caries excavation and hence, more tooth structure preservation12. This was confirmed by Freedman and Goldstep36 who reported that polymer burs were efficient in removing infected carious dentin selectively as their cutting edges blunted out when they became in contact with hard or affected dentin.
The 3-year clinical evaluation of esthetic properties did not show any significant differences for all resin composite restorations overlying both liners. This could be attributed to the presence of nanofillers with particle size below the wavelength of visible light leading to significant light absorption without light scattering and so, superior esthetic outcomes37. Also, nanofiller particles provide composites with high color stability, high translucency, high polish retention, low surface roughness, and low staining susceptibility38. This result is in agreement with Mahmoud et al.39 who reported that nanofilled composite restorations had excellent color match with the surrounding tooth structure in addition to the high surface luster after 2-year follow-up period. Another clinical trial performed by Dresch et al.40 stated that using nanofilled composite in posterior teeth showed high esthetic outcomes after 1 year of clinical examination.
Only three composite restorations suffered from a slight change in staining criterion after 3 years. This marginal staining occurring in the crevice between the restoration and the cavity wall could be related to pigment and stains absorption from dietary habits. The use of liners in this study did not have any significant influence on the esthetic outcomes, since they were used in a thin layer that could not be seen through26.
No composite restorations were fractured during the 3-year follow-up. This could be attributed to the combination of nanomer and nanocluster filler particles in nanofilled composite which decreases the interstitial spacing leading to high filler loading and enhanced physical and mechanical properties41. Moreover, the nanofillers might act as point that could prevent crack propagation and restoration fracture42. This result is in accordance with a previous study43 which showed that nanofilled resin composite had high flexural strength and excellent mechanical properties.
Resin composite restorations exhibited excellent marginal adaptation with no significant differences detected during the different recall periods. This could be related to the application of universal adhesive system which enhanced the bond durability owing to presence of functional monomer (10-MDP) that interacts chemically with hydroxyapatites. Selective enamel etching also increased the bond strength to enamel and resulted in long-lasting marginal seal44. The presence of remaining remineralizable dentin surrounded by sound dentin after selective caries excavation did not has a negative effect on the marginal integrity of composite restorations as confirmed by Scholz et al.45. A study conducted by Sauro et al.46 showed that ion-releasing lining materials had an important role on the longevity of resin composite restorations bonded by universal adhesive. All marginal gaps were detected using two special probes (150 and 250 μm) during the follow-up periods22. Only three restorations showed a slight change in marginal adaptation over time which could be resulted from the degradation of the resin/bond interface as a result of slow water hydrolysis.
Clinical evaluation of wear was performed to assist in understanding the restorative material behavior when submitted to the complex oral masticatory changes. Based on the findings of this clinical study, resin composite restorations did not show any significant alterations in occlusal contour during all of the recall visits. This could be attributed to the higher flexural strength and wear resistance of nanofilled resin composite as reported in previous study42. It has been suggested that wear of resin composite is dependent on filler loading, formulation of resin matrix, adhesion of fillers to the matrix and filler size47. This result was confirmed by Frankenberger et al.48 who reported that nanocomposites had satisfactory clinical performance regarding the wear rates over the 8-year observation period. In contrast, Yesil et al.49 reported that incorporation of nanofillers in resin composite materials did not significantly enhance wear resistance.
Digital bitewing and periapical radiographs were taken to aid in the detection of restoration gaps, secondary caries, apical pathological changes, and material loss that might be difficult to be detected clinically22. The results of this study showed no differences in radiographic outcomes between both tested groups during the 3-year evaluations. Moreover, no periapical changes related to any restoration were found. This could be attributed to bioactivity and fluoride release of the used cavity liners which enhanced the remineralization of caries-affected dentin and prevented caries progression preserving pulp vitality.
Each patient was asked about his/her opinion regarding esthetics, pain, function, hypersensitivity, and comfort during chewing. Most of patients were satisfied with their restorations, where no esthetic or functional problems were detected. However, only two patients reported minor criticism which could be related to the changes in restorations’ surface texture.
The clinical evaluation for postoperative hypersensitivity involved type of pain, duration, and stimulating factors. Also, the effect of the tested lining materials on pulp vitality response was evaluated by comparing the reaction of restored tooth to that of a vital unrestored tooth using cold ice22. According to outcomes of this clinical trial, there was no significant difference regarding postoperative hypersensitivity between both tested groups through the follow-up periods. This could be attributed to the active ionic resin matrix and shock absorbing rubberized fillers in Activa Bioactive liner which bond chemically to tooth structure and provide sealing against bacterial leakage and thus, reducing sensitivity. Moreover, Activa Bioactive has the ability to release and recharge calcium, phosphate, and fluoride ions provoking the mineral apatite formation and remineralization50. This was supported by Hirani et al.51 who reported that there was no postoperative hypersensitivity related to Activa Bioactive material. A previous report52 stated that Activa Bioactive had higher degree of biocompatibility and healing ability when compared to calcium silicate-based cement. Conversely, Van Dijken et al.53 reported that the postoperative hypersensitivity of Activa Bioactiva could be related the severe weakness of initial bond to the cavity walls which led to progressing deterioration of material adaptation. Furthermore, a clinical study performed by Weston et al.54 concluded that using RMGI liners prevented hypersensitivity and microleakage owing to the extended fluoride release and the remineralization effect. A previous study38 reported that RMGI materials had minimum sensitivity which could be explained by the durable bond to dentin, dimensional stability, and excellent adaptation with the tooth structure. On the contrary, Strober et al.55 reported that using RMGI liners did not decrease the clinically evaluated postoperative hypersensitivity.
The absence of recurrent and secondary caries over time could be related to the selection of well-motivated participants with good oral hygiene status in addition to the instructions given to all of them after the placement of the restorations. Moreover, the proper restorative techniques and the adequate marginal seal of the restorations prevented the bacterial penetration. The antibacterial and remineralizing ability of Activa Bioactive and Riva Light Cure liners had a crucial role in caries prevention, as well both lining materials showed high bond strength to dentin and resin composite which might prevent secondary caries and microleakage as reported by a previous laboratory study50. This finding was in agreement with a clinical trial56 which stated that both Activa Bioactive and RMGI scored 100% success after 1 year regarding the recurrence of decay. Conversely, Abou ElReash et al.57 reported that Activa Bioactive had weak antibacterial properties due to its resinous ingredients and scantily acidic nature.
Clinical investigation of tooth integrity was performed visually to detect tooth or enamel fracture, cracks, and chipping23. No tooth fracture was detected during the different recalls for both groups. This could be related to the minimal invasive cavity preparation which prevented the weakening of remaining tooth structure and maintained its integrity. In the present study, none of cases showed oral or general symptoms during the 3-year follow-up periods. This might be related to the exclusion of patients with adverse medical conditions and systemic diseases. Furthermore, all the materials used in this study were approved by the FDA.
The clinical evaluation of proximal contact and contour for Class II restorations was carried out by passing waxed dental floss through contact area to detect contact deficiency which might lead to food impaction, plaque accumulation, secondary caries, and patient discomfort22,23. The current study results indicated no significant differences in approximal anatomical form between both groups throughout the follow-up periods. This could be explained by utilization of the sectional matrix system and wedges that led to strong contact points and correct contours in Class II restorations. This was confirmed by De la Pena et al.58 who stated that using sectional matrix was the best way to accomplish strong contact point in Class II restorations. When compared baseline to the different recall periods, no gingival inflammation, plaque accumulation, or pockets were found related to any restoration. Also, all cases showed healthy mucosa adjacent to the restorations without any allergic reactions or periodontal problems. This could be related to the well-established contacts and contours which prevented the food impaction.
The outcomes of the current clinical trial are limited by small sample size and limited number of treated teeth in addition to the short follow-up period. It would be recommended to perform future long-term randomized clinical trials evaluating ion-releasing liners in large number of patients with high recall rates to test these materials for further clinical applications.
Conclusion
Resin composite restorations showed acceptable clinical performance over 3 years either lined with bioactive ionic or resin-modified glass ionomer liners after selective caries excavation preserving pulp vitality.
Data availability
The datasets used and/or analyzed during the current study available from the corresponding author on reasonable request.
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Acknowledgements
The authors would like to thank Pulpdent, Watertown, MA, USA for donating the Activa Bioactive Base/Liner for trial.
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Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB).
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H.H. and S.M. designed this study. B.A. and R.W. conduct most of the clinical work of this study. R.W. and B.A. wrote the initial draft of the manuscript. H.H. and S.H. participate in the evaluation of the outcome and data analysis. H.H. and S.M. revised the manuscript.
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Ahmed, B., Wafaie, R.A., Hamama, H.H. et al. 3-year randomized clinical trial to evaluate the performance of posterior composite restorations lined with ion-releasing materials. Sci Rep 14, 4942 (2024). https://doi.org/10.1038/s41598-024-55329-6
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DOI: https://doi.org/10.1038/s41598-024-55329-6
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