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The article on “Dietary patterns interact with the variations of 18q21.23 rs17782313 locus on regulation of hypothalamic-pituitary axis hormones and cardio-metabolic risk factors in obesity” is very interesting [1]. Mohammadi et al. noted that “being on CC genotype of rs17782313 polymorphism made obese individuals more prone to have higher SBP, insulin and AgRP even in highest adherence to PDP [1]”. Indeed, the rs17782313 polymorphism basically results in molecular change that can further affect final phenotypic expression. Nevertheless, there are also other factors that might alter the phenotypic expression. Regarding the cardio-metabolic risk factors in obesity, there might also be possible effects of other genetic polymorphisms such as cocaine and amphetamine-regulated transcript prepropeptide gene polymorphisms [2]. Further studies that assess the effects of those confounding genetic polymorphisms should be set.
References
Mohammadi M, Khodarahmi M, Kahroba H, Farhangi MA (2020) Dietary patterns interact with the variations of 18q21.23 rs17782313 locus on regulation of hypothalamic-pituitary axis hormones and cardio-metabolic risk factors in obesity. Eat Weight Disord. https://doi.org/10.1007/s40519-020-00855-1
Mahmoudi-Nezhad M, Farhangi MA, Kahroba H (2020) Cocaine and amphetamine-regulated transcript prepropeptide gene (CARTPT) polymorphism interacts with Diet Quality Index-International (DQI-I) and Healthy Eating Index (HEI) to affect hypothalamic hormones and cardio-metabolic risk factors among obese individuals. J Transl Med 18(1):16. https://doi.org/10.1186/s12967-020-02208-z
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Joob, B., Wiwanitkit, V. Variations of 18q21.23 rs17782313 locus and regulation of hypothalamic-pituitary axis hormones and cardio-metabolic risk factors in obesity. Eat Weight Disord 26, 743 (2021). https://doi.org/10.1007/s40519-020-00879-7
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DOI: https://doi.org/10.1007/s40519-020-00879-7