Abstract
Acute respiratory distress syndrome (ARDS) is characterized by local inflammation and an intense systemic inflammatory reaction. Glucocorticoid administration has been suggested due to their anti-inflammatory properties. However, results from the initial studies of glucocorticoids in ARDS, which evaluated high-dose and short-term treatments, were negative. More recent studies have evaluated the effect of lower doses of glucocorticoids administered over longer periods, but the results thus far have been inconclusive.
Résumé
Le syndrome de détresse respiratoire aiguë (SDRA) est caractérisé par une inflammation locale et une réaction inflammatoire systémique intense. L’administration de glucocorticoïdes a été proposée en raison de leurs propriétés anti-inflammatoires. Cependant, les résultats des premières études concernant la prescription des glucocorticoïdes dans le SDRA, qui ont évalué de hautes doses avec des traitements de court terme, ont été négatifs. Des études plus récentes ont évalué des doses plus basses administrées sur des périodes plus longues, mais les résultats ont aussi été peu concluants.
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Cet article correspond à la conférence faite par l’auteur au congrès de la SRLF 2012 dans la session: SDRA au quotidien.
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Roche-Campo, F., Aguirre-Bermeo, H. & Mancebo, J. Glucocorticoids in the treatment of acute respiratory distress syndrome. Réanimation 21 (Suppl 2), 391–398 (2012). https://doi.org/10.1007/s13546-011-0316-1
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DOI: https://doi.org/10.1007/s13546-011-0316-1