Abstract
In vivo fluoroscopy is a well-known technique to analyze joint kinematics of the replaced knee. With this method, however, the contact areas between femoral and tibial components, fundamental for monitoring wear and validating design concepts, are hard to identify. We developed and tested a novel technique to assess condylar and post-cam contacts in TKA. The technique uses in vivo motion data of the replaced knee from standard fluoroscopy as input for finite element models of the prosthesis components. In these models, tibiofemoral contact patterns at the condyles and post-cam articulations were calculated during various activities. To test for feasibility, the technique was applied to a bicruciate posterior-stabilized prosthesis. Sensitivity of the finite element analysis, validation of the technique, and in vivo tests were performed. To test for potential in the clinical setting, five patients were preliminarily analyzed during chair rising-sitting, stair climbing, and step up-down. For each task and patient, the condylar contact points and contact line rotation were calculated. The results were repeatable and consistent with corresponding calculations from traditional fluoroscopic analysis. Specifically, natural knee kinematics, which shows rolling back and screw home, seemed replicated in all motor tasks. Post-cam contact was observed on both the anterior and posterior faces. Anterior contact is limited to flexion angle close to extension; posterior contact occurs in deeper flexion but is dependent on the motor task. The data suggest the proposed technique provides reliable information to analyze post-cam contacts.
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Introduction
It is believed the general goals of TKA are achieved by restoring normal knee kinematics. Various methods have been used to analyze the kinematics of both the intact and replaced knee [3, 24, 33]. These methods have included in vitro cadaveric measurements [18, 26, 37], gait analysis with motion systems [2, 3, 42], roentgen stereophotogrammetric analyses [32, 36], quasidynamic MRI testing [23, 29], and in vivo video fluoroscopy [10, 11, 24, 39]. Studies on cadaveric knees suffer from the difficult estimation and setting of the loading conditions in vivo and from the inability of actuators to reproduce loading and motion conditions accurately [12]. Roentgen stereophotogrammetric analyses often have been performed under nonweightbearing conditions but are quasidynamic [32, 35, 36]. Instrumented gait analysis is an easy method for gathering kinematic and kinetic data of the human knee in vivo for noninvasive analyses of its function in physiologic and various pathologic conditions [17, 26]. However, owing to motion of the skin markers relative to the underlying bone, critical motion artifact may occur [11, 40].
In vivo videofluoroscopy enables the reconstruction of three-dimensional (3D) position and orientation (pose) of the knee prosthesis components more accurately unhindered by the soft tissues around the joint [40]. Registration algorithms estimate the pose of the components from single-plane projection views on fluoroscopic image series [13, 38, 39]. This method has the advantage of testing under in vivo, weightbearing, fully dynamic conditions, while subjects perform various motor tasks. These have included gait [12], stair [15], and deep knee bends [30]. In addition to standard joint kinematics [41], fluoroscopy-based 3D techniques have largely been used to estimate anteroposterior (AP) and mediolateral (ML) displacement of the contact points [8, 9, 24, 27] at each sampled instant (frame), which is important for clinically related observations and deductions, such as restrictions to the range of motion, risks of wear, constraints for joint stability, etc, as well as for supporting novel concepts of TKA design. Although the various techniques proposed differ for a number of features, measurement accuracy for each moving segment is typically from 0.5 to 1.0 mm for translation in the image plane and from 0.5° to 1.0° for rotation. However, in the frequent case of single-plane fluoroscopy, motion perpendicular to the image plane has at best an accuracy in the range of 3.0 to 6.0 mm [5, 6, 19, 25, 31].
Because of this inaccuracy in determining implant pose and because of the complex shape of the components, the identification of the real contact points using fluoroscopy is particularly critical. Frequently, these contact points are assumed to be the closest points to the tibial baseplate of the femoral prosthetic condyles, independent of the shape and position of the polyethylene insert in between [4, 6]. When there is large conformity between the femoral component and the insert, particularly in full extension in a number of designs, the estimation can be even more sensitive to error. In addition, these estimations are obtained frame by frame, independent of previous or following conditions, and as a contact between two rigid bodies, without taking into account the deformation of these objects, which are also loaded in vivo. This also prevents any pressure distribution analysis, particularly relevant for the polyethylene insert. These are all issues typically addressed by finite element (FE) analysis, but rarely has this been utilized in combination with real in vivo replaced knee kinematics [22].
We report here an innovative technique for determining these contact points between the femoral component and the insert in patients with TKA. The technique utilized real in vivo 3D kinematics obtained from fluoroscopy as input for FE models of the prosthesis specially designed for the purpose. In addition to the commonly used contacts at the femoral prosthetic condyles, the models analyzed the contact between the femoral cam and the tibial post. This technique was used to analyze five patients during chair rising-sitting, stair climbing, and step up-down. The contact points obtained with the innovative technique were compared with those obtained with the traditional “closest point” technique.
Materials and Methods
Five patients affected by primary osteoarthritis received a rotationally unconstrained fixed-bearing prosthesis (Journey® Bi-Cruciate Stabilized Knee System; Smith & Nephew, Inc, Memphis, TN). These patients were selected among those with well-functioning knees and assessed clinically and by videofluoroscopy at 1-year followup. According to the International Knee Society scoring system [28], these were successful implants, with an average score of 163 (standard deviation, 9.1). The overall investigation was conducted in conformity with local ethical regulations; in particular informed consent for participation in the study was obtained from each patient.
Patients were analyzed by videofluoroscopy (digital remote-controlled diagnostic Alpha90SX16; CAT Medical System, Rome, IT) at 10 frames per second during chair rising-sitting, stair climbing, and step up-down. Attention was paid to position the fluoroscopic 32-cm-wide field of view to enable collection of the largest number of images of the replaced knee during the motor task. Two, three, and one repetitions, respectively, were collected for each of these tasks. For the latter, four cycles of up-down motion were collected within a single repetition. The height of the staircase steps was 21 cm. The chair and single-step heights were set for each patient so that he/she started from about 80° and 65° knee flexion, respectively [7]. By means of further images of a 3D cage and a grid of small tantalum beads, a technique for obtaining 3D positions and orientations of the prosthesis components was utilized as described elsewhere [16]. This technique was based on CAD-model shape matching. Relative flexion between the tibial and femoral components was represented using a standard joint convention [21]. With this traditional technique, the condylar contact is assumed to be at a unique contact point on the medial and lateral sides where the minimum distance between the femoral condyles and the tibial baseplate is observed. This also included calculation of the contact line rotation, defined as the rotation on the tibial baseplate of the projection of the line connecting the medial and lateral condylar contact points with respect to the ML axis of the baseplate. This line can show the instantaneous internal/external rotation angle for the knee. The AP translation of these contact points on this plane was also calculated during the three activities.
The in vivo kinematics obtained from fluoroscopy was used as an input for FE models of the implants to calculate condylar contact points between the femoral and tibial components. Initially, a full FE model (Fig. 1A) of the femoral component and polyethylene insert was developed in Abaqus/Explicit™ (Abaqus, Inc, Providence, RI) from the original CAD models of the implant. The femoral component was considered a rigid surface and represented by triangular surface elements (~11,500 elements), and the tibial insert by eight-node 3D hexahedral elements (~15,500 elements). The tibial insert was considered fixed, and the femoral component moved according to the in vivo relative kinematics obtained from fluoroscopy. Young’s modulus and Poisson ratio assumed for the femoral component were, respectively, 97.905 GPa and 0.3 [45]. The polyethylene insert was treated as a nonlinear elastoplastic material according to literature data [20, 22]. The contact points were determined by the FE software as the centroid of the pressure distribution between the femoral condyles and the tibial insert [1].
A sensitivity analysis was performed to evaluate the effects of errors in the position of the components intrinsic to the technique of 3D kinematics from the single-plane fluoroscopy. This component position is more critically estimated than any component orientation with this technique. In particular, for each possible “theoretical” original position, ie, the one obtained directly from fluoroscopy-based analysis, four additional positions of the tibial insert were analyzed for 1-mm displacement in the medial, lateral, anterior, and posterior directions. At the four different initial positions, together with the “theoretical” position, the same measured kinematics of the femoral component from fluoroscopy was applied, and the relevant ML and AP displacements of the condylar contact points were compared.
The results of the sensitivity analysis (see Results) showed a different FE model was needed to effectively analyze the contact points (Fig. 1B). The femur model remained the same while each tibial condyle was modeled as a flat box using eight-node 3D hexahedral elements. A similar sensitivity analysis, as described above, demonstrated this model was somewhat insensitive to changes of the model parameters. In particular, a more elastic material produced only larger contact areas but essentially the same location for the centroid of pressure. To avoid large vibration effects on the boxes due to penetration of the femoral condyles, the boxes were assumed to move together with the femoral component in such a way as to maintain a constant penetration of 2 mm.
For each patient and motor task, the medial and lateral contact point coordinates were determined and plotted versus the knee flexion angle. Similar to what is calculated with traditional fluoroscopic-based analysis, the rotation of the contact lines in the tibial baseplate was estimated with their pivot point, ie, the least-square approximation of the intersection of all the contact lines.
This technique was validated using a knee kinematics simulator (Fig. 2). A custom-built six-degrees-of-freedom dynamic knee simulator based on the Oxford rig [14, 34, 44] was used. A loaded squat exercise, until 120° of knee flexion, was simulated. A Journey® Bi-Cruciate Stabilized Knee prosthesis was mounted on the simulator using metal fixtures. Clusters of three markers were attached to the tibial and femoral fixtures to record their movement using four Vicon MX40 motion capture cameras (Vicon, Oxford, UK) with a proven accuracy of 0.3 mm in each direction [43]. The kinematics obtained from the experiment was used as input for the FE model. The contact points coordinates estimated with the FE model were compared with the centroid of pressure obtained using contact pressure sensors (K-Scan® 9000 psi; Tekscan, Inc, South Boston, MA) during the experiment.
A separate FE model was used to analyze post-cam contact. The standard FE model of the femoral component was used together with an original model of the isolated post of the tibial insert (Fig. 1C). The use of only the post instead of the entire tibial insert was chosen to reduce the computational time while maintaining the integrity of the analysis. The fluoroscopy-based kinematics was applied to the femoral component, and the occurrence of contact was evaluated. Three possible situations were considered: anterior contact, posterior contact, and no contact between the cam and the post. Whether there was contact or not was decided based on two criteria. Whenever the contact pressure and/or the contact area at the anterior or posterior face of the post exceeded a threshold value, 0.05 MPa and 0.25 mm2, respectively, the post and cam were considered to be in contact, as determined during a preliminary test.
For this technique, a sensitivity analysis to the AP positioning was also performed. For this purpose, the initial AP position of the post was changed by ± 1 mm and the resulting change in the post-cam contact situation was assessed.
The described FE techniques were used to analyze the original fluoroscopy-based kinematics from the five patients. One representative full cycle of chair rising-sitting, stair climbing, and step up-down at the replaced knee was analyzed. The results were compared with the corresponding measurements from standard fluoroscopy analysis. With this technique, replaced joint kinematics and contacts were consistent among patients.
Results
The analysis of the influence of possible different initial positions (Fig. 3) showed the original full FE model was too sensitive to the inaccuracy in the prosthesis component positions typical of fluoroscopic-based knee kinematics calculation: 1 mm of error in the initial position could induce more than 3 mm of error in the contact point estimation.
The location of the centroid of pressure obtained from the FE model corresponded well with the experimental measurements (Fig. 4), showing a maximum deviation of less than 2 mm. This deviation was within the range of accuracy of the Tekscan sensor (shown in orange; Fig. 4).
FE analysis resulted in a more smooth and continuous motion with respect to the rather discrete and discontinuous pattern from traditional fluoroscopy, resulting in more plausible contact line rotations over time (Fig. 5). Nevertheless, the range of contact line rotation and the location of the pivot point remained nearly the same in the two techniques. This was revealed clearly by the graphs showing the motion of the contact points versus flexion angle (Fig. 6) and the internal/external rotation over time of the contact line (Fig. 7).
Consistent motion patterns were observed for all patients for each motor task (Fig. 8). A larger posterior displacement was observed for the lateral condyle, as a function of flexion, compared to the medial condyle. This implied replication of the rolling back and screw home mechanisms. Moreover, a ML displacement of both condyles was also seen (Fig. 8). The location of the pivot point was different from patient to patient (Table 1).
FE-based calculations resulted in smooth and consistent patterns of contact also at the post-cam interface; a typical output of this analysis for stair climbing in one patient is shown (Fig. 9). These patterns of post-cam contact in the anterior and posterior areas, in addition to the no-contact condition, along the flexion arc, were found also consistent among patients in all three analyzed motor tasks (Fig. 10). For all three motor tasks, anterior contact was more frequent at small flexion angles (near full extension), and posterior contact occurred in larger flexion. The analysis of sensitivity to the AP position showed the transition point between two different contact situations in the flexion-extension curve plotted versus time changed by a maximum of 5°. This showed the technique was relatively insensitive to errors of this kind.
Discussion
To overcome the limitations of the traditional 3D fluoroscopic analysis of the joint kinematics in TKA patients and to analyze more reliably contact patterns at these joints, an innovative technique was developed based on FE models. A sensitivity analysis and an experimental validation were performed and reported. In vivo 3D kinematics obtained by fluoroscopy during chair rising-sitting, stair climbing, and step up-down from five patients with a TKA were used as input for these models. The FE technique reproduced well the contact points displacement derived from fluoroscopy but with smoother, more credible and consistent patterns. In addition, for the first time, the models enabled the in vivo analysis of the contact between the femoral cam and the tibial post. Both the condylar and the post-cam contact patterns supported the design features of the analyzed knee implant.
A number of shortcuts were taken in FE modeling to make these calculations feasible and reliable at the same time. The 2-mm constant penetration was taken as a compromise solution between opposite factors after a series of preparatory tests: to avoid separation between the femoral component and insert (which produces no contact estimation during the analysis), a large depth would be required; to reduce vibration effects and the relevant large increase of computational time, a small depth would be recommended. With the penetration used, no relevant differences in the contact point locations were found. Two different criteria were adopted to determine contact between the post and the cam because we wanted to exclude numerical artifacts inherent to FE modeling where a continuous body is discretized in separate elements. This can lead either to virtual contact between single nodes, which is not realistic, or to extremely low pressure values, which are irrelevant. To exclude the former error, we defined a small area threshold; to exclude the latter error, we defined a lower contact pressure threshold. An additional weakness of the study is the limited size of the patient population, although the main aim was to propose and test the technique first; more consistent and robust clinical analyses can now follow. Furthermore, also the acquisition by means of single-plane fluoroscopy could represent a limitation to the study. Nevertheless, past and recent studies have demonstrated the reliability and repeatability of the fluoroscopic technique we utilized [7, 15, 16].
A sensitivity analysis of the technique used was performed. As expected, the intrinsic error of single-plane fluoroscopy in the prosthesis component positioning, particularly in the ML direction, resulted in a large difference of the condylar contact point locations. Therefore, a number of modifications were made. The complexity of the original shapes of the polyethylene insert was replaced by two independent boxes and a single post. Appropriate mechanical characteristics of the box material were chosen to avoid vibrational effects and distortion of elements and to reduce computational time. An experimental test proved the validity of this approach.
This study is innovative in its combination of in vivo kinematics and FE analysis. The relative motion of the components is the most critical input for the models, considerably affecting the final results. Relative movement data are usually taken from measurements performed with external markers, which are unreliable. On the other hand, fluoroscopy-based kinematics and contact analyses are performed frequently without the support of prosthesis-specific models for the contacts. Our results support the reliability of the traditional measurements based only on fluoroscopy. Nevertheless, the results also demonstrate the necessity of FE models for a more realistic estimation of the condylar contacts and for additional information about in vivo post-cam engagement.
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One or more of the authors (BI, LL) are employees of Smith & Nephew, Inc, Memphis, TN.
Each author certifies that his or her institution has approved the human protocol for this investigation, that all investigations were conducted in conformity with ethical principles of research, and that informed consent for participation in the study was obtained.
This work was performed at Istituto Ortopedico Rizzoli (fluoroscopy data collection and analysis) and at the European Center for Knee Research, Smith & Nephew (finite element-based modeling).
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Catani, F., Innocenti, B., Belvedere, C. et al. The Mark Coventry Award Articular: Contact Estimation in TKA Using In Vivo Kinematics and Finite Element Analysis. Clin Orthop Relat Res 468, 19–28 (2010). https://doi.org/10.1007/s11999-009-0941-4
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DOI: https://doi.org/10.1007/s11999-009-0941-4