Abstract
This review aims to explain the inevitable imbalance between respiratory load, drive, and muscular force that occurs in the natural aging of Duchenne muscular dystrophy and that predisposes these patients to sleep disordered breathing (SDB). In DMD, SDB is characterized by oxygen desaturation, apneas, hypercapnia, and hypoventilation during sleep and ultimately develops into respiratory failure during wakefulness. It can be present in all age groups. Young patients risk obstructive apneas because of weight gain, secondary to progressive physical inactivity and prolonged corticosteroid therapy; older patients hypoventilate and desaturate because of respiratory muscle weakness, in particular the diaphragm. These conditions are further exacerbated during REM sleep, the phase of maximal muscle hypotonia during which the diaphragm has to provide most of the ventilation. Evidence is given to the daytime predictors of early symptoms of SDB, important indicators for the proper time to initiate mechanical ventilation.
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Introduction
Sleep is an actively regulated physiological process essential for the whole human being. The most important function of sleep is to allow the brain to reorganize its neuronal activity to the point that “sleep is of the brain, by the brain and for the brain” [1]. Sleep-induced alterations occur not only to brain activity but also to other physiological processes like heart rate, blood pressure, sympathetic nerve activity, body temperature, sexual arousal, and respiration.
Sleep disorders are chronic conditions and are frequently comorbid with other syndromes and conditions [2]. Patients with neuromuscular diseases are especially prone to sleep disordered breathing (SDB), being in turn a strong contributor to the morbidity of the disease itself establishing a dangerous vicious cycle.
The aim of the present review is to explain the mechanisms of this vicious cycle in Duchenne muscular dystrophy (DMD). It also provides a brief description on how it can be potentially treated and eventually predicted. In this review, priority is given to the specific studies dealing only with DMD instead of nonspecific studies including several neuromuscular disorders other than DMD.
Normal Sleep in Humans
There are three states of being: wakefulness, rapid eye movement (REM) sleep, and non-REM (NREM) sleep.
In more recent literature, NREM sleep is composed of three different stages (previous classifications defined four different stages) each characterized by unique and specific brain wave patterns and muscular tone. NREM sleep starts with a short period of stage 1 characterized by alpha waves and is the transitional stage between wakefulness and sleep. Stage 2 is the first unequivocal stage of sleep that is mainly characterized by theta waves. Stage 3 is referred to as slow-wave sleep or deep sleep and is characterized by the presence of delta waves. Stage 3 sleep combines the previous classifications of stages 3 and 4. NREM sleep constitutes 75–80% of total sleep time. The remaining 20–25% of sleep time consists of REM sleep that normally follows NREM stage 3 and is characterized by bursts of rapid eye movements, EEG desynchronization, and loss of muscle tone and reflexes. REM sleep is not a homogenous state. It comprises a phase wherein bursts of rapid eye movements occur and a tonic phase characterized by no eye movements, skeletal muscle atonia, and a desynchronized low-voltage EEG pattern [3].
During sleep, a regular cyclic alternation of REM and NREM phases occurs throughout the night and is associated with dynamic and physiological changes in systemic processes and bodily functions [1, 2, 4, 5]. Sleep architecture commonly occurs in sleep cycles where the first sleep cycle lasts between 70 and 100 min, and the remaining sleep cycles last roughly 90 min each. Every sleep cycle finishes with REM sleep. In the first sleep cycle, the REM stage may only last a moment or a few minutes, but as the sleep cycles progress through the night, stage 3 sleep is progressively replaced by REM sleep and, in the final sleep, cycles may replace it entirely, i.e., REM follows directly stage 2 [6].
The Control of Breathing
The respiratory muscles do not have an intrinsic rhythmicity being totally dependent on the efferent impulses coming from the respiratory center. The respiratory control of breathing is composed of two mechanisms that are anatomically distinct but functionally integrated. The first mechanism is a suprapontine control system that includes both voluntary and behavioral influences together with the wakefulness drive to breathe. The second mechanism is an autonomic metabolic and mechanical control, therefore completely involuntary. These mechanisms are both integrated in the respiratory center from which they modulate output in order to meet the ventilatory demands [7, 8].
In the transition from wakefulness to sleep, the suprapontine input is suppressed. During sleep, respiration is entirely regulated by metabolic factors alone that in healthy subjects guarantee adequate gas exchange and provide a stable respiratory pattern [8,9,10]. More in detail, a supraspinal inhibition of γ-motoneurons and presynaptic afferent terminals from muscle spindles occurs during REM sleep with relatively preserved α-motoneurons [8, 10].
The metabolic control of breathing is modulated and regulated by chemoreceptors, whereas the mechanical control is modulated and regulated by mechanoreceptors [11].
There are two types of chemoreceptors: the peripheral and the central ones. Peripheral chemoreceptors are located in the carotid sinus and in the aortic body, and they respond to changes of arterial partial pressure of oxygen (PaO2) [12]. The more PaO2 decreases, the more the afferent activity from the carotid body increases, making respiratory rate increase in order to augment minute ventilation. This is known as the hypoxic ventilatory response. This hypoxic response becomes lower with deeper sleep. Also, the arousal response to breathing resistance becomes lower in NREM stage 3 [13].
Central chemoreceptors are located in the medulla oblongata and in the midbrain. They are sensitive to changes in pH and also indirectly to arterial partial pressure variations of carbon dioxide (PaCO2). A decreasing arterial pH triggers these chemoreceptors to make minute ventilation increase, with corresponding decrease in PaCO2 that, in turn, prompts an increment of pH. When pH rises, a compensatory reduction of minute ventilation makes PaCO2 increase to reduce pH back to physiological levels. This is known as the hypercapnic ventilatory response [14, 15].
Peripheral chemoreceptors also respond to PaCO2 changes, with carotid body also being sensitive to changes in pH, but to a lesser extent and more rapidly compared to the central ones.
Carbon dioxide (CO2)-induced hypercapnia does not induce changes in the corticomotor excitability of either the diaphragm or the genioglossus [15, 16].
Mechanoreceptors are located in the airway smooth muscles, in the alveoli, and in the respiratory muscles, being sensitive to lung stretch, increased interstitial fluid volume, and muscle fiber tension, respectively [14]. In tracheostomized patients or in the case of increased airway resistance, the fall in ventilation and the rise in end-tidal pCO2 during sleep are not altered. This indicates that chemoreceptors, rather than mechanoreceptors, are the primary controls of ventilation during sleep [17,18,19].
Cough reflex is suppressed during sleep [20]. Normal sleep is characterized by episodes of spontaneous arousal so that the suprapontine control system can return to control ventilation making the ventilatory drive increase in order to rapidly reduce PaCO2 back to wakefulness values [14, 21].
Sleep and Breathing
From a ventilatory point of view, sleep induces changes in the respiratory muscles in terms of electrical activity, fiber shortening, and action.
Different patterns characterize every sleep phase. During NREM sleep, the electrical activity of intercostal muscles increases by a means of 34% compared to wakefulness status, whereas the electrical activity of the diaphragm does not change [8, 22, 23, 24•]. As a consequence, ribcage contribution to tidal volume progressively increases with the deepness of NREM sleep and abdominal expansion decreases (Fig. 1) [8, 22, 23, 25, 26]. Trans-diaphragmatic pressure (PDI) increases by 20% in NREM sleep compared to the wakefulness state. This implies that the contraction of the diaphragm becomes more efficient, as it generates higher pressure with the same level of electrical activation [22].
During REM sleep, there is a change in the distribution of the respiratory effort among respiratory muscles [23, 27]. In fact, the electrical activity of lower lateral external intercostal muscles is inhibited [24•] and ribcage expansion, in turn, falls (Fig. 1) [8, 22, 23, 25, 26]. Parasternal intercostal muscles and the diaphragm, in both its costal and crural part, remain fully active [24•]. The diaphragmatic electrical activity substantially increases, while PDI decreases which implies that the efficiency of the diaphragm is reduced during REM sleep. This is confirmed by the fact that during REM sleep, tidal volume reduces, indicating that the action of the diaphragm is less effective than during the awake state [8, 25, 26, 28].
While diaphragmatic shortening does not change from wakefulness to sleep, the shortening of parasternal intercostal muscles decreases in both NREM and REM sleep despite the preservation of their electrical activity [24•]. The lesser contractility of parasternal intercostal muscles, i.e., reduced shortening per unit of electrical activity, and the differences in diaphragmatic efficiency may be attributed to the mechanical advantage/disadvantage of the overall changes in chest wall mechanics during sleep [8, 22, 24•]. The activation of intercostal muscles during NREM sleep may optimize the morphology of the diaphragm by increasing its length and/or radius of curvature [8, 22, 28]. During the REM sleep phase, the contraction of the diaphragm further increases making pleural pressure decrease. Intercostal muscles are inhibited with the exception of parasternal intercostal muscles. This means that parasternal intercostal muscles alone are not able to counteract the effects of the increased contraction of the diaphragm that is partially wasted in distorting the chest wall resulting in thoraco-abdominal asynchrony [8, 22, 24•, 28].
Taken together, these data show that (1) phrenic and parasternal motoneurons are spared by REM-related inhibition, (2) parasternal intercostal muscles remain active to provide ventilation also during REM sleep, and (3) parasternal intercostal muscles are essential inspiratory muscles like the diaphragm [9, 24•].
Pharyngeal and upper airway muscle tone is reduced during sleep, particularly during REM phase, making upper airway resistance increase [8, 14, 22, 29,30,31].
The result of sleep-induced motor inhibition of respiratory and airway muscles, the so-called REM “atonia,” is hypoventilation. Inspiratory flow, an index of inspiratory drive, minute ventilation, and its two components, namely breathing frequency and tidal volume, become faster and more irregular. The result is hypoventilation during sleep in particular during REM phase [8, 23, 25, 28, 30, 32,33,34].
Sleep Disordered Breathing
Several disorders affect sleep and are among the most commonly overlooked health problems that hinder daily activities and functions. The cumulative effect of these disorders may lead to a wide range of health problems such as hypertension, diabetes, obesity, depression, heart attack, and stroke [30, 35].
Among sleep disorders, sleep-related breathing disorders refer to four different types: (1) obstructive sleep apnea syndrome, (2) central sleep apnea syndrome, (3) sleep-related hypoventilation disorder, and (4) sleep-related hypoxemia disorder [36, 37].
Symptoms of SDB are excessive daytime sleepiness, fatigue, exertional dyspnea, decreased concentration, morning headaches, and mood changes [30, 38]. SDB may turn into deficient ventilation resulting in hypoxemia (reduced oxygen content in the blood, i.e., nocturnal SpO2 [oxyhemoglobin saturation] ≤90% for more than 5 min with a nadir ≤85 or 30% of total sleep time spent with an SpO2 of 90%), hypercapnia (increased levels of CO2 in the blood >45 mmHg) or both [35, 36].
Obstructive sleep apnea (OSA) and hypopneas are the most common disorders. They are respectively defined as complete or partial episodes of collapse of the pharyngeal airway resulting from relaxation of the soft tissue in the rear of the throat. Apneas/hypopneas create an obstruction to the air passing through the airway, and vigorous respiratory efforts are present. The direct consequence is the fall of blood oxygenation that leads to arousal accompanied by snorts or gasps when the patient manages to overcome the obstruction and resume breathing [12, 34, 39].
Central sleep apnea is due to a temporary reduction or cessation of central respiratory drive, the cause of which is occasionally unclear and labeled “idiopathic.” Patients consequently stop breathing until chemo-sensitivity increases to trigger hyperventilation in order to force PaCO2 below the apneic threshold [14, 35, 40, 41].
Apneas therefore fragmentize sleep in response to the breathing pauses, and this leads to excessive daytime sleepiness, reduced concentration, and mood changes [14, 39].
The sleep-induced hypoventilation and hypoxemia may be primary, as a consequence of blunted central/peripheral chemo-responsiveness, or because of a congenital condition. It may also be comorbid with different medical conditions including neuromuscular disorders. They impair the patient’s ability to breathe in terms of either dysfunction of respiratory motor innervation or respiratory muscle weakness. [36, 42].
Duchenne Muscular Dystrophy
Among the inherited diseases, DMD is the most common and severe form of myopathy in children that affects 1 out of 3600–6000 male births. It is caused by mutations in the dystrophin gene, resulting in progressive weakness and debilitation of all striated musculature, beginning with limb muscles and ending with respiratory muscles [43,44,45]. DMD patients experience progressive motor impairment, loss of ambulation before teen ages, severe, and ultimately cardiac and/or breathing failure, which is the ultimate cause of death [46,47,48,49].
Although no therapy is available, DMD patients’ life expectancy has significantly improved up to the fourth decade thanks to a comprehensive and structured therapeutic approach particularly targeted to respiratory care [50,51,52,53,54,55,56,57]. With the progression of the disease, in fact, respiratory muscles are affected and DMD patients are characterized by reduced force of their respiratory muscles. This leads to poor spirometry, restrictive lung pattern, rapid and shallow breathing, ineffective cough, SDB, and ultimately respiratory failure [58,59,60,61,62,63,64,65,66,67].
In particular, the diaphragm progressively shows increasing thickness that may indicate pseudo-hypertrophy due to infiltration of connective tissue and fat deposition [68]. It becomes progressively weak to the point that in the end, it paradoxically moves upwards leading to progressively reduced abdominal contribution to tidal volume in supine position (Fig. 2) [61]. The weakness of the diaphragm is the main cause of (1) reduced tidal volume and hypoventilation, (2) nocturnal desaturation, and (3) inefficient cough [61, 69,70,70].
Sleep Disordered Breathing in DMD
Respiratory failure is still the most common cause of death in DMD [45,46,47, 50,51,52,53,54,55,56,57,58,59]. Its evolution typically evolves in four stages: (1) SDB without hypercapnia, (2) hypercapnia and/or hypoxemia only during REM phase, (3) hypercapnia and/or hypoxemia also during NREM, and ultimately (4) diurnal chronic respiratory insufficiency [54, 56, 71,73,74,74].
Nocturnal oxygen desaturation is associated with a worse prognosis [75]. Unfortunately, the onset of respiratory insufficiency can be subtle in DMD to the point that patients and their parents are not aware that they are losing respiratory muscle strength and that the quality of their sleep is low. Unfortunately, the characteristics of DMD make these patients prone to develop nocturnal hypoventilation and therefore SDB. Nocturnal hypoventilation can be the consequence of either decreased ventilatory drive or worsening mechanics or a combination of the two.
In DMD, SDB has both nonobstructive and obstructive origins when respiratory, upper airway, and facial muscles become affected by the disease.
With the progression of DMD, functional residual capacity (FRC), and therefore the provision of oxygen in the alveoli, is reduced. This is also favored by the supine position that is known, per se, to reduce FRC [76, 77]. As a result, CO2 levels rise with ensuing of nocturnal hypoxemia [78,80,80]. The combination of such restrictive lung patterns with respiratory muscle weakness and severe scoliosis, typical of DMD, results in chronic nocturnal hypoventilation that causes pulmonary micro-atelectasis [61, 63, 66, 81,83,84,84]. This may lead to a ventilation-perfusion mismatch resulting in a pulmonary shunt, i.e., one or more areas with perfusion but no ventilation, another contributor of hypoxemia [85].
The progressively DMD-induced diaphragmatic weakness [61, 69] plays a big part in nocturnal hypoventilation for two reasons: (1) passing from orthostatism to clinostatism, the diaphragm becomes the respiratory muscle that leads inspiration and guarantees 70% of tidal volume [86,88,88]; (2) it is almost the only muscle to remain active during REM sleep after intercostal muscles’ depression [8, 22, 24•, 25, 26]. Therefore, when an “old” DMD patient lies in bed and reaches the REM sleep phase, his severely compromised diaphragm may not be able to adequately sustain the ventilatory demands. As a result, the most notable changes in DMD occur during REM sleep in terms of both poor tidal volume and hypoxemia [27, 79, 89].
REM timing in DMD shows a higher latency. This tendency of REM suppression may represent a compensatory mechanism to avoid the sleep phase during which patients are most vulnerable to oxygen desaturation [90••]. This seems confirmed by the fact that in four DMD patients, the reduction of the total time spent in REM sleep through protriptyline treatment was effective towards diminishing the related hypoxaemia and episodes of desaturation [91].
Other compensative and adaptive mechanisms, i.e., recruitment of sternocleidomastoid or other inspiratory extra-diaphragmatic muscles, are reported in patients with paralysis of the diaphragm [18, 92, 93]. These evidences suggest brainstem reorganization during REM sleep to cope with the paralysis of the diaphragm. There are no studies reporting similar compensative mechanisms in DMD.
DMD also involves facial and airway muscles, and this contributes to limit the oropharyngeal lumen therefore promoting obstructive sleep apneas particularly in the presence of obesity. The presence of OSA positively and strongly correlates with the body mass index in young boys with DMD [79, 94••]. Obesity therefore is a further predisposing factor of obstructive apneas, and it is common in DMD teenagers because of the forced progressive physical inactivity and of the long-term use of corticosteroid therapy [85, 95,97,97].
DMD patients can also develop macroglossia, a further contributor to obstructive events [18, 74]. Scoliosis is yet another severe feature of DMD that aggravates with age and is shown to worsen sleep quality, efficiency, architecture, and REM duration [98].
The more airway resistance increases and scoliosis degenerates, the higher the load for the already weak respiratory muscles. This further worsens hypoventilation and REM hypoxemia therefore ensuing a fatal vicious circle in DMD [71, 99].
SDB in DMD starts in the form of recurrent OSA, while in the second decade of life, it is mainly due to nocturnal hypoventilation and “pseudo-central apneas” secondary to respiratory muscle involvement. Hence, apneas in DMD evolve from obstructive to apparently central [38, 100]. The ventilatory pump becomes so weak that it is not able to produce the pressure swings needed to open the closed pharynx. In this way, the obstructive apnea is mislabeled as central: a pseudo-central apnea [90••, 101, 102].
Although DMD is a peripheral and not a central neuromuscular disease, central sleep apneas are also reported in young patients [74, 94••, 103]. In order to investigate the problematic presence of central apneas in DMD, invasive techniques, like gastro-esophageal catheters, should be used during sleep to measure the respiratory swings of pressure during efforts [104]; otherwise, it is more likely that OSA would be mistaken for central apnea [101].
A possible consequence of nocturnal hypoventilation, hypoxemia, and hypercapnia is that both peripheral and central respiratory chemoreceptors could become less sharp. This depresses the respiratory drive and determines a state of chronic alveolar hypoventilation that further worsens respiratory failure [85, 99]. Figure 3 summarizes the mechanisms that lead to SDB in Duchenne patients.
Nocturnal Noninvasive Mechanical Ventilation
Sleep disorders, namely hypoxemia, sleep fragmentation, and daytime sleep-induced impaired functions, are potentially treatable.
Supplementary oxygen therapy was the first solution applied in early 1990s. There is no doubt that it improves hypoxemia, but it is now used with great care because it may also depress the central respiratory drive, therefore prolonging apneas and exacerbating the risk of CO2 retention [8, 51, 55, 105,107,107].
To treat the SDB-induced hypoxemia, noninvasive ventilation (NIV) is needed. According to the internationally recognized guidelines, in fact, the structured approach to respiratory management in DMD comprises, among other treatments, the use of NIV to deal with nocturnal hypoventilation, SDB, and ultimately with respiratory failure [51, 54, 108, 109].
The earliest forms of NIV used negative pressures such as the “iron lung,” the rocking bed, and the abdominal cuirass. These forms of negative pressure ventilation brought the intrinsic complication of developing upper airway obstruction therefore leading to OSA with consequent episodes of arterial oxygen desaturation [110].
Nasal intermittent positive pressure ventilation (NIPPV) is largely used and has proven to be an efficient and beneficial treatment in DMD, able to increase survival in hypercapnic patients and improve arterial O2 and CO2 tensions [57].
It is also preferable to invasive mechanical ventilation requiring tracheostomy. In fact, the combination of NIV with cough aids leads to a lower hospitalization rate than invasive ventilation [111, 112]. The mechanisms of beneficial impact of NIV in daytime blood gases include resting of respiratory muscles [113, 114], recruitment of lung volume therefore reversing atelectasis, reset of the respiratory drive at the level of chemoreceptors, and delay daytime hypercapnia [60, 115, 116]. NIPPV should be started as an in-patient, and then it is well tolerated and easy to handle at home by the family [8].
Nasal continuous positive airway pressure has a limited application in DMD, because it just keeps the upper airway open without ventilating the patient. The problem is that when a DMD patient needs NIV, his respiratory muscles are weak to the point that they are not able to provide adequate ventilation [85].
Daytime Predictors of SDB and Indicators of NIV in DMD
Almost all the symptoms of SDB may be easily attributed to DMD per se with the risk to further delay the diagnosis of SDB [38, 117]. The fact that nocturnal hypoventilation occurs earlier than daytime awake respiratory impairment [71, 100] means that the first sign of respiratory failure in DMD starts during sleep, particularly during REM phase.
For this reason, nocturnal monitoring is necessary in these patients, as it may provide not only early detection of respiratory involvement but also becomes an important indication to intervene. It is still under debate, in fact, the proper time to initiate NIV in order to achieve maximal benefit: if it is started too early, there is the risk to induce atrophy in the diaphragm [118]; if it is started too late, respiratory failure can occur earlier leading to premature death risk [119].
Polysomnography (PSG) is a comprehensive, multi-parametric test used as a diagnostic tool in sleep medicine to study the physiological changes that occur during sleep. The functions monitored by PSG are cerebral cortical activity (electroencephalogram), eye movements, muscle activity mainly of mylohyoid (electromyography), cardiac activity (electrocardiogram), respiratory airflow, thoraco-abdominal movements, and peripheral pulse oximetry [120]. PSG is expensive, it needs complicated instruments, it presents logistic difficulties, and it is not universally available in the normal clinical practice. For this reason, simpler, specific, surrogate, and easy-to-obtain daytime indexes of SDB and of NIV use are needed. Such daytime predictors of severe nocturnal hypoventilation and/or hypoxemia may permit the identification of those patients most at risk of severe hypoxemia, particularly during respiratory tract infections, when airway obstruction increases and thoracic compliance decreases [71], on whom PSG becomes justified and therefore mandatory [72].
Hypercapnia and hypoxemia can be respectively detected by measuring PaCO2 and PaO2. These techniques have two disadvantages: they are invasive and they are measured during wakefulness, therefore not reflecting the sleep condition. Overnight transcutaneous pCO2 measurement and pulse oximetry are noninvasive techniques. The former slightly overestimates PaCO2 and it concordantly increases, while SpO2 decreases during REM hypoventilation [72]. The latter can be less sensitive particularly in early stages of DMD [56]. In order to identify clinical factors associated with the onset of SDB, it is important to test the concordance between laboratory PSG and portable monitoring systems [107, 121].
All the studies specific for DMD that are present in the literature and that contain both sleep characterization and daytime respiratory function are reported in Table 1. Some authors did not to find any relationship, whereas others found useful information like daytime predictors of SDB and indicators for the extent of need for NIV.
In order to find the optimum timing for starting NIV and to delay respiratory failure in DMD, it is important to measure respiratory function in terms of spirometry, lung volumes, respiratory muscles strength, and resting breathing patterns.
Among all the considered parameters, three of them should be put in evidence:
-
1.
Vital capacity: it is the most informative parameter, but spirometry requires repetition of maximal efforts that can fatigue the weak respiratory muscles, particularly in old DMD patients.
-
2.
Rapid and shallow breathing index: it is nonvolitional and it can be considered a global index of ventilatory pump weakness (“shallow”) and increased ventilatory drive (“rapid”). It requires the use of a mouthpiece that can be problematic in the presence of macroglossia and cheek muscles weakness.
-
3.
The abdominal contribution to tidal volume in supine position: it is nonvolitional, it does not need mouthpiece and it is a specific index of the action of the diaphragm.
To be noted that DMD being a degenerative progressive disease, it is extremely important to consider homogeneous age groups. The use of a wide range of ages, in fact, carries the risk of hiding important features by grouping together young and old patients, with the former to introduce positive bias due to their relatively less compromised condition.
Table 2 reports the international guidelines for the criterion of establishing nocturnal and daytime NIV in DMD.
Animal Model
Mdx mouse is an important, reliable, murine model for physiological studies of DMD, particularly for the diaphragm. While the degeneration of limb muscles of mdx mice does not parallel patients’, their diaphragm closely mirrors the pathophysiology, fibrosis, and severe functional deficit of DMD patients [124, 125].
Experimental protocols comprising intermittently induced episodes of hypoxia are used in animal models to simulate sleep apnea. It has been shown that exposure to episodic hypoxia may result in a 30% reduction in diaphragmatic strength in mdx mice and that respiratory dysfunctions are more severe in older mdx mice [126, 127].
The function of sternohyoid muscle, a pharyngeal dilator important for the control of airway patency, is compromised (in terms of poor force, work, and power) in mdx mice, but shows an apparent tolerance to acute hypoxic stress [128].
Another interesting study reveals that peripheral chemosensory response is reduced in mdx mice and that mdx mice show dysfunction of the carotid body [129].
Conclusion
SDB is expected in the natural history of DMD, and it ultimately results into respiratory failure during wakefulness. SDB can be present in all ages: young patients are placed at risk of obstructive apnea; older patients hypoventilate and desaturate during sleep because of the impairment of their respiratory muscles, in particular the diaphragm. This is further exacerbated during REM sleep, the phase of maximal muscle hypotonia during which the diaphragm has to carry the entirety of ventilation.
Daytime predictors of early symptoms of SDB and of the proper time to initiate mechanical ventilation can be found in spirometry and in the breathing pattern at rest.
“To sleep, perchance to dream. Ay, there’s the rub”
(Shakespeare, Hamlet. Act 3, Scene 1, Page 3)
References
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
Hobson JA. Sleep is of the brain, by the brain and for the brain. Nature. 2005;437(7063):1254–6.
Colten HR, Altevogt BM, Research I of M (US) C on SM and. Sleep disorders and sleep deprivation. Sleep disorders and sleep deprivation: an unmet public health problem. National academies press (US); 2006.
Ermis U, Krakow K, Voss U. Arousal thresholds during human tonic and phasic REM sleep. J Sleep Res. 2010;19(3):400–6.
Preedy VR, Patel VB, Le L-A, editors. Handbook of nutrition, diet and sleep. The Netherlands: Wageningen Academic Publishers; 2013.
Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki EA, Chikahisa S, et al. Sleep as a biological problem: an overview of frontiers in sleep research. J Physiol Sci. 2016;66(1):1–13.
Sleep disorders and sleep deprivation: an unmet public health problem. Institute of Medicine (US) Committee on Sleep Medicine and Research; Colten HR, Altevogt BM, editors. Washington (DC): National Academies Press (US); 2006.
Remmers JE. Central neural control of breathing. Altose MD, Kawakami Y, eds Control of breathing in health and disease. 1999. p. 1–35.
McNicholas WT. Impact of sleep in respiratory failure. Eur Respir J. 1997;10(4):920–33.
Remmers JE. Effects of sleep on control of breathing. Int Rev Physiol. 1981;23:111–47.
Phillipson EA. Control of breathing during sleep. Am Rev Respir Dis. 1978;118(5):909–39.
Honda Y. Chemical control of breathing. Altose MD, Kawakami Y, eds Control of Breathing in Health and Disease. 1999. p. 41–88.
Mansukhani MP, Wang S, Somers VK. Chemoreflex physiology and implications for sleep apnoea: insights from studies in humans. Exp Physiol. 2015;100(2):130–5.
Douglas NJ. Respiratory physiology: control of ventilation. Kryger MH, Roth T, Dement WC, editors Principles and Practice of Sleep Medicine 4th ed Philadelphia. 2005. p. 224–9.
Hernandez AB, Patil SP. Pathophysiology of central sleep apneas. Sleep Breath. 2016;20(2):467–82.
Berthon-Jones M, Sullivan CE. Ventilatory and arousal responses to hypoxia in sleeping humans. Am Rev Respir Dis. 1982;125(6):632–9.
Borel J-C, Melo-Silva CA, Gakwaya S, Rousseau E, Series F. Diaphragm and genioglossus corticomotor excitability in patients with obstructive sleep apnea and control subjects. J Sleep Res. 2016;25(1):23–30.
Morrell MJ, Harty HR, Adams L, Guz A. Breathing during wakefulness and NREM sleep in humans without an upper airway. J Appl Physiol. 1996;81(1):274–81.
Bourke SC, Gibson GJ. Sleep and breathing in neuromuscular disease. Eur Respir J. 2002;19(6):1194–201.
Gugger M, Molloy J, Gould GA, Whyte KF, Raab GM, Shapiro CM, et al. Ventilatory and arousal responses to added inspiratory resistance during sleep. Am Rev Respir Dis. 1989;140(5):1301–7.
Lee KK, Birring SS. Cough and sleep. Lung. 2010;S91–4.
Khoo MC. Periodic breathing and central apnea. Altose MD, Kawakami Y, eds Control of Breathing in Health and Disease. 1999. p. 203–50.
Lopes JM, Tabachnik E, Muller NL, Levison H, Bryan AC. Total airway resistance and respiratory muscle activity during sleep. J Appl Physiol. 1983;54(3):773–7.
Tabachnik E, Muller NL, Bryan AC, Levison H. Changes in ventilation and chest wall mechanics during sleep in normal adolescents. J Appl Physiol. 1981 Sep;51(3):557–64.
• Yokoba M, Hawes HG, Kieser TM, Katagiri M, Easton PA. Parasternal intercostal and diaphragm function during sleep. J Appl Physiol. 2016;121(1):59–65. This study for the first time shows that not only the diaphragm, but also parasternal intercostal muscles are active during REM sleep phase. This is an animal model and therefore it would be very interesting to verify if this is also valid for human. If this would be confirmed, parasternal intercostal muscles can be considered primary inspiratory muscles with the diaphragm.
Stradling JR, Chadwick GA, Frew AJ. Changes in ventilation and its components in normal subjects during sleep. Thorax. 1985;40(5):364–70.
Tusiewicz K, Moldofsky H, Bryan AC, Bryan MH. Mechanics of the rib cage and diaphragm during sleep. J Appl Physiol. 1977;43(4):600–2.
Kerr SL, Kohrman MH. Polysomnographic abnormalities in Duchenne muscular dystrophy. J Child Neurol. 1994;9(3):332–4.
Sa RC, Prisk GK, Paiva M. Microgravity alters respiratory abdominal and rib cage motion during sleep. J Appl Physiol. 2009;107(5):1406–12.
Sforza E, Bacon W, Weiss T, Thibaulta A, Petiau C, Krieger J. Upper airway collapsibility and cephalometric variables in patients with obstructive sleep apnea. Am J Respir Crit Care Med. 2000;161(2):347–52.
Colten HR, Altevogt BM, Research I of M (US) C on SM and. Sleep Disorders and Sleep Deprivation. Sleep disorders and sleep deprivation: an unmet public health problem. National Academies Press (US); 2006.
Lo Y-L, Jordan AS, Malhotra A, Wellman A, Heinzer RA, Eikermann M, et al. Influence of wakefulness on pharyngeal airway muscle activity. Thorax. 2007;62(9):799–805.
Douglas NJ, White DP, Pickett CK, Weil JV, Zwillich CW. Respiration during sleep in normal man. Thorax. 1982;37(11):840–4.
Gothe B, Altose MD, Goldman MD, Cherniack NS. Effect of quiet sleep on resting and CO2-stimulated breathing in humans. J Appl Physiol. 1981;50(4):724–30.
Gleeson K, Zwillich CW, White DP. Chemosensitivity and the ventilatory response to airflow obstruction during sleep. J Appl Physiol. 1989;67(4):1630–7.
Sateia MJ. International classification of sleep disorders-third edition. Chest. 2014;146(5):1387–94.
Casey KR, Cantillo KO, Brown LK. Sleep-related hypoventilation/hypoxemic syndromes. Chest. 2007;131(6):1936–48.
American Academy of Sleep Medicine. International classification of sleep disorders, 3rd ed. Darien. 2014.
Gordon N. Sleep apnoea in infancy and childhood. Considering two possible causes: obstruction and neuromuscular disorders. Brain and Development. 2002;24(3):145–9.
Stepanski E, Lamphere J, Badia P, Zorick F, Roth T. Sleep fragmentation and daytime sleepiness. Sleep. 1984;7(1):18–26.
Cowie MR. Central sleep apnoea: to treat or not to treat? Eur J Heart Fail. 2016;18(11):1394–5.
White DP. Pathogenesis of obstructive and central sleep apnea. Am J Respir Crit Care Med. 2005;172(11):1363–70.
Thorpy M. Classification of sleep-related breathing disorders. Kryger M, Roth T, Dement W (ed), Principles and Practice of Sleep Medicine (5th Edition). 2011. p. 680–93.
Emery AE. Population frequencies of inherited neuromuscular diseases--a world survey. Neuromuscul Disord. 1991;1(1):19–29.
Griggs RC, Bushby K. Continued need for caution in the diagnosis of Duchenne muscular dystrophy. Neurology. 2005;64(9):1498–9.
Bushby K, Finkel R, Birnkrant DJ, Case LE, Clemens PR, Cripe L, et al. Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management. Lancet Neurol. Elsevier Ltd. 2010;9(1):77–93.
Eagle M, Baudouin SV, Chandler C, Giddings DR, Bullock R, Bushby K. Survival in Duchenne muscular dystrophy: improvements in life expectancy since 1967 and the impact of home nocturnal ventilation. Neuromuscul Disord. 2002;12(10):926–9.
Gomez-Merino E, Bach JR. Duchenne muscular dystrophy: prolongation of life by noninvasive ventilation and mechanically assisted coughing. Am J Phys Med Rehabil. 2002;81(6):411–5.
Hsu JD, Quinlivan R. Scoliosis in Duchenne muscular dystrophy (DMD). Neuromuscul Disord Elsevier BV. 2013;23(8):611–7.
Hollingsworth KG, Garrood P, Eagle M, Bushby K, Straub V. Magnetic resonance imaging in Duchenne muscular dystrophy: longitudinal assessment of natural history over 18 months. Muscle Nerve. 2013;48(4):586–8.
Passamano L, Taglia A, Palladino A, Viggiano E, D’Ambrosio P, Scutifero M, et al. Improvement of survival in Duchenne muscular dystrophy: retrospective analysis of 835 patients. Acta Myol. 2012;31(OCTOBER):121–5.
Finder JD, Birnkrant D, Carl J, Farber HJ, Gozal D, Iannaccone ST, et al. Respiratory care of the patient with Duchenne muscular dystrophy: ATS consensus statement. Am J Respir Crit Care Med. 2004;170(4):456–65.
Bach JR, Martinez D. Duchenne muscular dystrophy: continuous noninvasive ventilatory support prolongs survival. Respir Care. 2011;56(6):744–50.
Ishikawa Y, Miura T, Ishikawa Y, Aoyagi T, Ogata H, Hamada S, et al. Duchenne muscular dystrophy: survival by cardio-respiratory interventions. Neuromuscul Disord. 2011;21(1):47–51.
Birnkrant DJ, Bushby KMD, Amin RS, Bach JR, Benditt JO, Eagle M, et al. The respiratory management of patients with Duchenne muscular dystrophy: a DMD care considerations working group specialty article. Pediatr Pulmonol. 2010;45(8):739–48.
Bushby K, Finkel R, Birnkrant DJ, Case LE, Clemens PR, Cripe L, et al. Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care. Lancet Neurol Elsevier Ltd. 2010;9(2):177–89.
Toussaint M, Chatwin M, Soudon P. Mechanical ventilation in Duchenne patients with chronic respiratory insufficiency: clinical implications of 20 years published experience. Chron Respir Dis. 2007;4(3):167–77.
Simonds AK, Muntoni F, Heather S, Fielding S. Impact of nasal ventilation on survival in hypercapnic Duchenne muscular dystrophy. Thorax. 1998;53(11):949–52.
McDonald CM, Henricson EK, Abresch RT, Han JJ, Escolar DM, Florence JM, et al. The cooperative international neuromuscular research group Duchenne natural history study--a longitudinal investigation in the era of glucocorticoid therapy: design of protocol and the methods used. Muscle Nerve. 2013;48(1):32–54.
Henricson EK, Abresch RT, Cnaan A, Hu F, Duong T, Arrieta A, et al. The cooperative international neuromuscular research group Duchenne natural history study: glucocorticoid treatment preserves clinically meaningful functional milestones and reduces rate of disease progression as measured by manual muscle testing and othe. Muscle Nerve. 2013;48(1):55–67.
Toussaint M, Soudon P, Kinnear W. Effect of non-invasive ventilation on respiratory muscle loading and endurance in patients with Duchenne muscular dystrophy. Thorax. 2008;63(5):430–4.
Lo Mauro A, D’Angelo MG, Romei M, Motta F, Colombo D, Comi GP, et al. Abdominal volume contribution to tidal volume as an early indicator of respiratory impairment in Duchenne muscular dystrophy. Eur Respir J. 2010;35(5):1118–25.
Stehling F, Dohna-Schwake C, Mellies U, Grosse-Onnebrink J. Decline in lung volume with Duchenne muscular dystrophy is associated with ventilation inhomogeneity. Respir Care. 2015;1–7.
Khirani S, Ramirez A, Aubertin G, Boulé M, Chemouny C, Forin V, et al. Respiratory muscle decline in Duchenne muscular dystrophy. Pediatr Pulmonol. 2014;49(5):473–81.
LoMauro A, Romei M, D’Angelo MG, Aliverti A. Determinants of cough efficiency in Duchenne muscular dystrophy. Pediatr Pulmonol. 2014;49(4):357–65.
Phillips MF, Quinlivan RC, Edwards RH, Calverley PM. Changes in spirometry over time as a prognostic marker in patients with Duchenne muscular dystrophy. Am J Respir Crit Care Med. 2001;164(12):2191–4.
Mayer OH, Finkel RS, Rummey C, Benton MJ, Glanzman AM, Flickinger J, et al. Characterization of pulmonary function in Duchenne muscular dystrophy. Pediatr Pulmonol. 2015;50(5):487–94.
Kravitz RM. Airway clearance in Duchenne muscular dystrophy. Pediatrics. 2009;123(Suppl(May)):S231–5.
De Bruin PF, Ueki J. Bush a, khan Y, Watson a, pride NB. Diaphragm thickness and inspiratory strength in patients with Duchenne muscular dystrophy. Thorax. 1997;52(5):472–5.
Nicot F, Hart N, Forin V, Boulé M, Clément A, Polkey MI, et al. Respiratory muscle testing: a valuable tool for children with neuromuscular disorders. Am J Respir Crit Care Med. 2006;174(1):67–74.
Romei M, D’Angelo MG, Lomauro A, Gandossini S, Bonato S, Brighina E, et al. Low abdominal contribution to breathing as daytime predictor of nocturnal desaturation in adolescents and young adults with Duchenne muscular dystrophy. Respir Med Elsevier Ltd. 2012;106(2):276–83.
Smith PE, Calverley PM, Edwards RH. Hypoxemia during sleep in Duchenne muscular dystrophy. Am Rev Respir Dis. 1988;137(4):884–8.
Hukins CA, Hillman DR. Daytime predictors of sleep hypoventilation in Duchenne muscular dystrophy. Am J Respir Crit Care Med. 2000;161(1):166–70.
Toussaint M, Steens M, Soudon P. Lung function accurately predicts hypercapnia in patients with Duchenne muscular dystrophy. Chest. 2007;131(2):368–75.
Barbé F, Quera-Salva MA, McCann C, Gajdos P, Raphael JC, de Lattre J, et al. Sleep-related respiratory disturbances in patients with Duchenne muscular dystrophy. Eur Respir J. 1994;7(8):1403–8.
Phillips MF, Smith PE, Carroll N, Edwards RH, Calverley PM. Nocturnal oxygenation and prognosis in Duchenne muscular dystrophy. Am J Respir Crit Care Med. 1999;160(1):198–202.
Stam H, Kreuzer FJ, Versprille A. Effect of lung volume and positional changes on pulmonary diffusing capacity and its components. J Appl Physiol. 1991;71(4):1477–88.
Benedik PS, Baun MM, Keus L, Jimenez C, Morice R, Bidani A, et al. Effects of body position on resting lung volume in overweight and mildly to moderately obese subjects. Respir Care. 2009;54(3):334–9.
Hahn A, Bach JR, Delaubier A, Renardel-Irani A, Guillou C, Rideau Y. Clinical implications of maximal respiratory pressure determinations for individuals with Duchenne muscular dystrophy. Arch Phys Med Rehabil. 1997;78(1):1–6.
Manni R, Zucca C, Galimberti CA, Ottolini A, Cerveri I, Bruschi C, et al. Nocturnal sleep and oxygen balance in Duchenne muscular dystrophy. A clinical and polygraphic 2-year follow-up study. Eur Arch Psychiatry Clin Neurosci. 1991;240(4–5):255–7.
Manni R, Ottolini A, Cerveri I, Bruschi C, Zoia MC, Lanzi G, et al. Breathing patterns and HbSaO2 changes during nocturnal sleep in patients with Duchenne muscular dystrophy. J Neurol. 1989;236(7):391–4.
Phillips MF, Quinlivan RCM, Edwards RHT, Calverley PM. A. Changes in spirometry over time as a prognostic marker in patients with duchenne muscular dystrophy. Am J Respir Crit Care Med. 2002;164(12):2191–4.
Tangsrud S, Petersen IL, Lødrup Carlsen KC, Carlsen KH. Lung function in children with Duchenne’s muscular dystrophy. Respir Med. 2001;95(11):898–903.
Gayraud J, Ramonatxo M, Rivier F, Humberclaude V, Petrof B, Matecki S. Ventilatory parameters and maximal respiratory pressure changes with age in Duchenne muscular dystrophy patients. Pediatr Pulmonol. 2010;45(6):552–9.
Shapiro F, Zurakowski D, Bui T, Darras BT. Progression of spinal deformity in wheelchair-dependent patients with Duchenne muscular dystrophy who are not treated with steroids: coronal plane (scoliosis) and sagittal plane (kyphosis, lordosis) deformity. Bone Joint J. 2014;96–B(1):100–5.
Guilleminault C, Shergill RP. Sleep-disordered breathing in neuromuscular disease. Curr Treat Options Neurol. 2002;4(2):107–12.
Romei M, Mauro AL, D’Angelo MG, Turconi AC, Bresolin N, Pedotti a, et al. Effects of gender and posture on thoraco-abdominal kinematics during quiet breathing in healthy adults. Respir Physiol Neurobiol. 2010;172(3):184–91.
Stradling JR, Chadwick GA, Quirk C, Phillips T. Respiratory inductance plethysmography: calibration techniques, their validation and the effects of posture. Bull Eur Physiopathol Respir. 1985;21(4):317–24.
Macklem PT. Normal and abnormal function of the diaphragm. Thorax. 1981;36(3):161–3.
Smith PE, Edwards RH, Calverley PM. Ventilation and breathing pattern during sleep in Duchenne muscular dystrophy. Chest. 1989;96(6):1346–51.
•• Nozoe KT, Moreira GA, Tolino JRC, Pradella-Hallinan M, Tufik S, Andersen ML. The sleep characteristics in symptomatic patients with Duchenne muscular dystrophy. Sleep Breath. 2015;19(3):1051–6. In this study polysomnography was performed in 44 Duchenne patients and 79 healthy subjects. A detailed description of the compromised sleep and respiratory profile during sleep specifically for DMD is therefore provided.
Smith PE, Edwards RH, Calverley PM. Protriptyline treatment of sleep hypoxaemia in Duchenne muscular dystrophy. Thorax. 1989;44(12):1002–5.
Bennett JR, Dunroy HMA, Corfield DR, Hart N, Simonds AK, Polkey MI, et al. Respiratory muscle activity during REM sleep in patients with diaphragm paralysis. Neurology. 2004;62(1):134–7.
Arnulf I, Similowski T, Salachas F, Garma L, Mehiri S, Attali V, et al. Sleep disorders and diaphragmatic function in patients with amyotrophic lateral sclerosis. Am J Respir Crit Care Med. 2000;161(3):849–56.
•• Sawnani H, Thampratankul L, Szczesniak RD, Fenchel MC, Simakajornboon N. Sleep disordered breathing in young boys with Duchenne muscular dystrophy. J Pediatr. 2015;166(3):640–5. This is a retrospective study on 111 DMD boys younger than 18 years. Pulmonary function test and polysomnogram are analyzed in order to provide a detailed description of sleep disordered breathing in young DMD boys with DMD.
Jeronimo G, Nozoe KT, Polesel DN, Moreira GA, Tufik S, Andersen ML. Impact of corticotherapy, nutrition, and sleep disorder on quality of life of patients with Duchenne muscular dystrophy. Nutrition. 2016;32(3):391–3.
Davidson ZE, Ryan MM, Kornberg AJ, Sinclair K, Cairns A, Walker KZ, et al. Observations of body mass index in Duchenne muscular dystrophy: a longitudinal study. Eur J Clin Nutr. 2014;68(8):892–7.
Martigne L, Salleron J, Mayer M, Cuisset J-M, Carpentier A, Neve V, et al. Natural evolution of weight status in Duchenne muscular dystrophy: a retrospective audit. Br J Nutr. 2011;105(10):1486–91.
Polat M, Sakinci O, Ersoy B, Sezer RG, Yilmaz H. Assessment of sleep-related breathing disorders in patients with duchenne muscular dystrophy. J Clin Med Res. 2012;4(5):332–7.
Bye PT, Ellis ER, Issa FG, Donnelly PM, Sullivan CE. Respiratory failure and sleep in neuromuscular disease. Thorax. 1990;45(4):241–7.
Suresh S, Wales P, Dakin C, Harris M-A, Cooper DGM. Sleep-related breathing disorder in Duchenne muscular dystrophy: disease spectrum in the paediatric population. J Paediatr Child Health. 2005;41(9–10):500–3.
Khan Y, Heckmatt JZ. Obstructive apnoeas in Duchenne muscular dystrophy. Thorax. 1994 Feb;49(2):157–61.
Smith PE, Edwards RH, Calverley PM. Mechanisms of sleep-disordered breathing in chronic neuromuscular disease: implications for management. Q J Med. 1991;81(296):961–73.
Barbé F, Quera-Salva MA, Agustí AG. Apnoea in Duchenne muscular dystrophy. Thorax. 1995;50(10):1123.
ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002;166(4):518–624.
Smith PE, Edwards RH, Calverley PM. Oxygen treatment of sleep hypoxaemia in Duchenne muscular dystrophy. Thorax. 1989;44(12):997–1001.
Bach JR, Rajaraman R, Ballanger F, Tzeng AC, Ishikawa Y, Kulessa R, et al. Neuromuscular ventilatory insufficiency: effect of home mechanical ventilator use v oxygen therapy on pneumonia and hospitalization rates. Am J Phys Med Rehabil. 1998;77(1):8–19.
Hoque R. Sleep-disordered breathing in Duchenne muscular dystrophy: an assessment of the literature. J Clin Sleep Med. 2016;12(6):905–11.
Finsterer J. Cardiopulmonary support in Duchenne muscular dystrophy. Lung. 2006;184(4):205–15.
Wagner KR, Lechtzin N, Judge DP. Current treatment of adult Duchenne muscular dystrophy. Biochim Biophys Acta. 2007;1772(2):229–37.
Hill NS, Redline S, Carskadon MA, Curran FJ, Millman RP. Sleep-disordered breathing in patients with Duchenne muscular dystrophy using negative pressure ventilators. Chest. 1992;102(6):1656–62.
Bach JR, Ishikawa Y, Kim H. Prevention of pulmonary morbidity for patients with Duchenne muscular dystrophy. Chest. 1997;112(4):1024–8.
Baydur A, Gilgoff I, Prentice W, Carlson M, Fischer DA. Decline in respiratory function and experience with long-term assisted ventilation in advanced Duchenne’s muscular dystrophy. Chest. 1990;97(4):884–9.
Belman MJ, Soo Hoo GW, Kuei JH, Shadmehr R. Efficacy of positive vs negative pressure ventilation in unloading the respiratory muscles. Chest. 1990;98(4):850–6.
Carrey Z, Gottfried SB, Levy RD. Ventilatory muscle support in respiratory failure with nasal positive pressure ventilation. Chest. 1990;97(1):150–8.
Schönhofer B, Geibel M, Sonneborn M, Haidl P, Köhler D. Daytime mechanical ventilation in chronic respiratory insufficiency. Eur Respir J. 1997;10(12):2840–6.
Toussaint M, Steens M, Wasteels G, Soudon P. Diurnal ventilation via mouthpiece: survival in end-stage Duchenne patients. Eur Respir J. 2006;28(3):549–55.
Gozal D. Pulmonary manifestations of neuromuscular disease with special reference to Duchenne muscular dystrophy and spinal muscular atrophy. Pediatr Pulmonol. 2000;29(2):141–50.
Hussain SNA, Cornachione AS, Guichon C, Al Khunaizi A, Leite F. De S, Petrof BJ, et al. prolonged controlled mechanical ventilation in humans triggers myofibrillar contractile dysfunction and myofilament protein loss in the diaphragm. Thorax. 2016;71(5):436–45.
Benditt JO, Boitano L. Respiratory support of individuals with Duchenne muscular dystrophy: toward a standard of care. Phys Med Rehabil Clin N Am. 2005;16(4):1125–39.
Berry RB, Budhiraja R, Gottlieb DJ, Gozal D, Iber C, Kapur VK, Marcus CL, Mehra R, Parthasarathy S, Quan SF, Redline S, Strohl KP, Davidson Ward SL. TMAA of SM. Rules for scoring respiratory events in sleep: update of the 2007 AASM manual for the scoring of sleep and associated events. Deliberations of the sleep apnea definitions task force of the American Academy of sleep medicine. J Clin Sleep Med. 2012;8(5):597–619.
Kirk VG, Flemons WW, Adams C, Rimmer KP, Montgomery MD. Sleep-disordered breathing in Duchenne muscular dystrophy: a preliminary study of the role of portable monitoring. Pediatr Pulmonol. 2000;29(2):135–40.
Hahn A, Duisberg B, Neubauer BA, Stephani U, Rideau Y. Noninvasive determination of the tension-time index in Duchenne muscular dystrophy. Am J Phys Med Rehabil. 2009;88(4):322–7.
Hamada S, Ishikawa Y, Aoyagi T, Ishikawa Y, Minami R, Bach JR. Indicators for ventilator use in Duchenne muscular dystrophy. Respir Med. Elsevier Ltd. 2011;105(4):625–9.
Stedman HH, Sweeney HL, Shrager JB, Maguire HC, Panettieri RA, Petrof B, et al. The mdx mouse diaphragm reproduces the degenerative changes of Duchenne muscular dystrophy. Nature. 1991;352(6335):536–9.
Grady RM, Teng H, Nichol MC, Cunningham JC, Wilkinson RS, Sanes JR. Skeletal and cardiac myopathies in mice lacking utrophin and dystrophin: a model for Duchenne muscular dystrophy. Cell. 1997;90(4):729–38.
Farkas GA, McCormick KM, Gosselin LE. Episodic hypoxia exacerbates respiratory muscle dysfunction in DMD(mdx) mice. Muscle Nerve. 2007;36(5):708–10.
Chaudhari MR, Fallavollita JA, Farkas GA. The effects of experimental sleep apnea on cardiac and respiratory functions in 6 and 18 month old dystrophic (mdx) mice. PLoS One. 2016;11(1):e0147640.
Burns DP, O’Halloran KD. Evidence of hypoxic tolerance in weak upper airway muscle from young mdx mice. Respir Physiol Neurobiol. 2016;226:68–75.
Mosqueira M, Baby SM, Lahiri S, Khurana TS. Ventilatory chemosensory drive is blunted in the mdx mouse model of Duchenne muscular dystrophy (DMD). PLoS One. 2013;8(7):e69567.
Acknowledgements
This study is supported by Fondo DMD “Amici di Emanuele.” A special thanks goes to David Kuller for his corrections and suggestions.
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Antonella Lo Mauro, Maria Grazia D’Angelo, and Andrea Aliverti declare that they have no conflict of interest.
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LoMauro, A., D’Angelo, M.G. & Aliverti, A. Sleep Disordered Breathing in Duchenne Muscular Dystrophy. Curr Neurol Neurosci Rep 17, 44 (2017). https://doi.org/10.1007/s11910-017-0750-1
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DOI: https://doi.org/10.1007/s11910-017-0750-1