Abstract
Piroxicam–excipient (chitosan or cellulose) mixtures after mechanical activation were investigated using DSC. Crystallization of amorphous piroxicam was detected near 80°C in the mixtures of the components activated separately. If the components in the mixture are activated together, amorphous piroxicam does not crystallize at heating.
Both excipients interact with piroxicam, decreasing its melting point and enthalpy of melting. Mechanical activation intensifies the interaction, decreasing the melting point by 8°C and reducing the enthalpy of melting two times.
Both excipients interact identically with piroxicam, affecting identically its melting parameters. Nevertheless, the two excipients affect its solubility in water very differently. Cellulose does not change the solubility, but chitosan increases it ten times. The mechanism of piroxicam dissolution from the mixture with an excipient is discussed.
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Drebushchak, V., Shakhtshneider, T., Apenina, S. et al. Thermoanalytical investigation of drug–excipient interaction. J Therm Anal Calorim 86, 303–309 (2006). https://doi.org/10.1007/s10973-005-7440-y
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DOI: https://doi.org/10.1007/s10973-005-7440-y