Abstract
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract caused by a dysregulated immune response to the fecal microbiota. Very early-onset inflammatory bowel disease (VEO-IBD) refers to a subgroup of pediatric patients with IBD diagnosed before 6 years of age. This subgroup is often characterized by increased severity, aggressive progression, strong family history of IBD, and often poor response to conventional treatments. Nutritional therapies have been utilized to treat IBD, but their role in VEO-IBD is unclear. Disease behavior in VEO-IBD is often different from disease in adolescents and adults, as it is often restricted to the colon and refractory to standard medical therapies. Up to 25% of VEO-IBD patients have an identified underlying immunodeficiency, which may impact response to therapy. While specific mutations in interleukin 10 (IL-10), the IL-10 receptor (IL-10R), and mutations in NCF2, XIAP, LRBA, and TTC7 have been identified in VEO-IBD, polymorphisms in these genes are also associated with increased risk of developing IBD in adolescence or adulthood. We describe two cases in which infants presenting with VEO-IBD achieved clinical remission using exclusive enteral nutrition, a formula-based diet which has been shown to induce remission in older children with active Crohn’s disease.
Avoid common mistakes on your manuscript.
Introduction
Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract caused by a dysregulated immune response to the fecal microbiota. Very early-onset inflammatory bowel disease (VEO-IBD) refers to a subgroup of pediatric patients with IBD diagnosed before 6 years of age. This subgroup is often characterized by increased severity, aggressive progression, strong family history of IBD, and often poor response to conventional treatments [1–3]. Nutritional therapies have been utilized to treat IBD, but their role in VEO-IBD is unclear. Disease behavior in VEO-IBD is often different from disease in adolescents and adults, as it is often restricted to the colon and refractory to standard medical therapies. Up to 25% of VEO-IBD patients have an identified underlying immunodeficiency, which may impact response to therapy. While specific mutations in interleukin 10 (IL-10) [4], the IL-10 receptor (IL-10R) [5], and mutations in NCF2, XIAP, LRBA, and TTC7 have been identified in VEO-IBD, polymorphisms in these genes are also associated with increased risk of developing IBD in adolescence or adulthood [6–9]. We describe two cases in which infants presenting with VEO-IBD achieved clinical remission using exclusive enteral nutrition, a formula-based diet which has been shown to induce remission in older children with active Crohn’s disease [10].
Case 1
A 10-month-old boy presented to gastroenterology clinic for a 2-month history of frequent stooling and intermittent bloody diarrhea. He was breastfeeding and eating age-appropriate foods. Mother had removed dairy, soy, and eggs from their diets without improvement. The patient was otherwise in good health, with normal activity and without fevers. Initial laboratory values were significant for an elevated erythrocyte sedimentation rate (ESR) of 20 mm/h (normal <10 mm/h). He was started on an oral probiotic and continued on an elimination diet. At his 1-month follow-up visit, his ESR was 22 mm/h and hematocrit (Hct) had decreased to from 35 to 32%. Given continued symptoms and abnormal laboratory values, endoscopy was preformed (Table 1).
The patient had a visually normal esophagogastroduodenoscopy (EGD), but colonoscopy revealed patchy erythema from the rectum to the transverse colon. Biopsies returned showing granulomatous gastritis, duodenitis, and chronic active colitis with mild-to-moderate activity. The patient underwent immunology work-up including neutrophil oxidation burst assay which did not reveal a primary immunological disorder. He was started on EEN as primary therapy with intact cow’s milk protein-based formula, Pediasure. By 2 weeks of therapy, his symptoms had improved significantly with reduced blood in his stools, but he continued to have an elevated ESR (34 mm/h) and anemia (Hct 32.3). By week 8 of therapy, he was clinically asymptomatic with normal ESR (9 mm/h), a large interval decline in fecal calprotectin, however, persistently elevated (529 mcg/g) (Table 1). After much discussion about medical therapy options, given the patient’s clinical well-being, parents opted for the specific carbohydrate diet (SCD) as primary maintenance therapy with plans for close follow-up. At the time of transition to the SCD, patient was asymptomatic. With the introduction of solid foods, bloody diarrhea recurred, and therefore, EEN was restarted and sulfasalazine was initiated, and symptoms improved over the following month of EEN, but did not go into complete clinical remission. Due to concerns with dependence on formula and the beginning of food refusal, the patient was started on prednisolone and methotrexate and advanced to a normal diet. The patient entered clinical remission and was able to be weaned off of prednisolone. Dose escalation of methotrexate was required because of continued elevated sedimentation rate which normalized thereafter. He has been in clinical remission for over 18 months, with normalization of his ESR (5 mm/h) and CRP (<0.4 mg/dL).
Case 2
A 2-month-old boy presented to gastroenterology clinic for a 1 month history of frequent loose stools, intermittent hematochezia, anemia, and elevated CRP. He had been diagnosed by his primary care provider with multiple episodes of gastroenteritis and milk protein allergy. On presentation, he was noted to have an ESR of 83 mm/h and CRP of 2.6 mg/dL (normal <0.8 mg/dL), anemia (Hct 23.1%), and mild hypoalbuminemia (3.8 g/dL). The patient underwent endoscopy. EGD was visually normal, while the colon revealed erythematous, friable mucosa with shallow ulcers, and exudate in the descending and transverse colon (Fig. 1). Biopsies revealed mild active inflammation with chronic architectural changes in the rectum and sigmoid colon. The descending colon demonstrated moderate to severely active inflammation with ulceration, and the transverse colon demonstrated focal mild active inflammation. At the time of colonoscopy, the patient was found to have worsening anemia with Hct of 20.1% and therefore admitted to the hospital for transfusion. He was started on EEN with an amino acid-based hypoallergenic infant formula (Elecare Infant).One month later, he was clinically asymptomatic, however, had persistently elevated ESR (69 mm/h) and anemia (Hct 27.3). After two months of EEN therapy, and after much discussion with the family about therapy options, solid foods from the SCD were introduced per parental preference. By four months of therapy (partial enteral nutrition and SCD foods), he continued to be in clinical remission and by 22 months of age was transitioned off of EEN and exclusively onto the SCD. Further work-up revealed no known immunodeficiency. His CRP had normalized; however, he continued to have persistent elevation in ESR (35 mm/h) and macrocytic anemia (hematocrit 26.8%, MCV 97.1) (Table 2). His anemia was further worked up and determined to be from a mutation known to cause Diamond–Blackfan Anemia and continues to follow with hematology. Clinically, he remained asymptomatic with normal CRP but mild elevation in ESR. Therefore, given persistent elevation of inflammatory markers despite clinical quiescence, he underwent repeat colonoscopy 23 months after diagnosis. He was found to have a visually normal colon with only mild chronic colitis without activity on microscopic examination (Fig. 2). The continued elevation in sedimentation rate was felt to be related to ongoing anemia associated with Diamond–Blackfan (Table 3).
Discussion
Although similar medication therapies are used in VEO-IBD as well as conventional IBD, these cases illustrate the positive impact on EEN in VEO-IBD. In older pediatric populations, EEN has been shown to induce remission in approximately 85% of newly diagnosed Crohn’s patients and has the equivalent response to corticosteroids in children with Crohn’s disease [11]. However, no studies have yet addressed the role of EEN in VEO-IBD population [10].
The North American Society of Gastroenterology (NASPGHAN) recommends EEN as a primary therapy for children with inflammatory Crohn’s disease [11]. EEN is associated with minimal side effects as well as better mucosa healing when compared to steroids [12, 13]. Our experience in infants with VEO-IBD shows that EEN can be efficacious and well suited for this age group [12]. A major parental concern for our first child was breaking the dependency to formula and introducing foods as he got older. This may be amplified in the very young VEO-IBD population during the critical time of food introduction.
A multicenter prospective observational study evaluated the clinical presentation and therapeutic management of VEO-IBD and identified an increased administration of corticosteroid and immunomodulators in VEO-IBD patients compared to patients with similar disease activity in other age groups [14]. This important finding was thought to be related to more aggressive phenotype in this population and/or increased awareness of the importance of mucosal healing [14]. This study supports the need for safe and effective therapeutic options, such as EEN, for the VEO-IBD population. It may be the case that EEN as primary or adjunctive therapy alongside immunosuppression is superior to immunosuppression alone. Certain risk allele genotypes have been associated with efficacy of EEN in pediatric Crohn’s disease, and further characterization of genetic risk in VEO-IBD may help guide the use of EEN in this population [15].
EEN as a treatment option in VEO-IBD also improves the nutritional status of our patients. While the nutritional benefits of EEN have been well studied in older children with IBD, it is equally or more important in the VEO-IBD population [16]. The use and protocols of EEN vary widely both nationally and internationally; therefore, studying the outcomes of therapy can be challenging. Given the small population of VEO-IBD and young age of presentation, it would be ideal to create protocols and study the role of EEN as primary or adjunctive therapy in this patient population.
References
Uhlig HH. Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease. Gut. 2013;62:1795–1805.
de Ridder L, Weersma RK, Dijkstra G, et al. Genetic susceptibility has a more important role in pediatric-onset Crohn’s disease than in adult-onset Crohn’s disease. Inflamm Bowel Dis. 2007;13:1083–1092.
Benchimol EI, Mack DR, Nguyen GC, et al. Incidence, outcomes, and health services burden of very early onset inflammatory bowel disease. Gastroenterology. 2014;147:803–813 e807; quiz e814–805.
Glocker EO, Frede N, Perro M, et al. Infant colitis—it’s in the genes. Lancet. 2010;376:1272.
Glocker EO, Kotlarz D, Boztug K, et al. Inflammatory bowel disease and mutations affecting the interleukin-10 receptor. N Engl J Med. 2009;361:2033–2045.
Foster CB, Lehrnbecher T, Mol F, et al. Host defense molecule polymorphisms influence the risk for immune-mediated complications in chronic granulomatous disease. J Clin Invest. 1998;102:2146–2155.
Muise AM, Xu W, Guo CH, et al. NADPH oxidase complex and IBD candidate gene studies: identification of a rare variant in NCF2 that results in reduced binding to RAC2. Gut. 2012;61:1028–1035.
Abo A, Pick E, Hall A, Totty N, Teahan CG, Segal AW. Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature. 1991;353:668–670.
Matute JD, Arias AA, Wright NA, et al. A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity. Blood. 2009;114:3309–3315.
Heuschkel RB, Menache CC, Megerian JT, Baird AE. Enteral nutrition and corticosteroids in the treatment of acute Crohn’s disease in children. J Pediatr Gastroenterol Nutr. 2000;31:8–15.
Critch J, Day AS, Otley A, et al. Use of enteral nutrition for the control of intestinal inflammation in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2012;54:298–305.
Zachos M, Tondeur M, Griffiths AM. Enteral nutritional therapy for induction of remission in Crohn’s disease. Cochrane Database Syst Rev. 2007;1:CD000542.
Borrelli O, Cordischi L, Cirulli M, et al. Polymeric diet alone versus corticosteroids in the treatment of active pediatric Crohn’s disease: a randomized controlled open-label trial. Clin Gastroenterol Hepatol. 2006;4:744–753.
Oliva-Hemker M, Hutfless S, Al Kazzi ES, et al. Clinical Presentation and five-year therapeutic management of very early-onset inflammatory bowel disease in a large North American cohort. J Pediatr. 2015;167:527–532 e521–523.
Frivolt K, Schwerd T, Werkstetter KJ, et al. Repeated exclusive enteral nutrition in the treatment of paediatric Crohn’s disease: predictors of efficacy and outcome. Aliment Pharmacol Ther. 2014;39:1398–1407.
Gerasimidis K, Talwar D, Duncan A, et al. Impact of exclusive enteral nutrition on body composition and circulating micronutrients in plasma and erythrocytes of children with active Crohn’s disease. Inflamm Bowel Dis. 2012;18:1672–1681.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Miller, T.L., Lee, D., Giefer, M. et al. Nutritional Therapy in Very Early-Onset Inflammatory Bowel Disease: A Case Report. Dig Dis Sci 62, 2196–2200 (2017). https://doi.org/10.1007/s10620-017-4616-9
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10620-017-4616-9