Abstract
We study two sequential, response-adaptive randomized designs for clinical trials; one has been proposed in Bandyopadhyay and Biswas (Biometrika 88: 409–419, 2001) and in Biswas and Basu (Sankhya Ser B 63:27–42, 2001), the other stems from the randomly reinforced urn introduced and studied in Muliere et al. (J Stat Plan Inference 136:1853–1874, 2006a). Both designs can be used in clinical trials where the response from each patient is a continuous variable. Comparison is conducted through numerical studies and along a new guideline for the evaluation of a response-adaptive design.
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Paganoni, A.M., Secchi, P. A numerical study for comparing two response-adaptive designs for continuous treatment effects. Stat. Meth. & Appl. 16, 321–346 (2007). https://doi.org/10.1007/s10260-006-0042-4
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DOI: https://doi.org/10.1007/s10260-006-0042-4