Abstract
Background
Helicobacter pylori is an established cause of gastritis and has been implicated in extradigestive diseases.
Objective
To investigate the role ofH. pylori in patients with unexplained refractory pruritus.
Methods
Ten patients with severe pruritus unresponsive to conventional therapy were evaluated for activeH. pylori infection byH. pylori serology followed by either esophagogastroduodenoscopy (EGD) or urea breath test. Of the 10 patients, 8 were found to have active infection. All 10 received anti-H. pylori antibiotic therapy and were reevaluated for relief of pruritus.
Results
Of 8 patients with activeH. pylori infection, 87.5% (7/8) had some type of pruritus relief after triple therapy. Of these, 62.5% (5/8) had complete relief and 25% (2/ 8) had temporary relief of pruritus. The remaining 12.5% (1/8) did not respond. Two control patients without activeH. pylori infection had no relief of pruritus with therapy.
Conclusions
We have identified a population of patients with refractory pruritus and activeH. pylori infection whose pruritus resolved after eradication ofH. pylori.
Sommaire
Antécédents
Helicobacter pyloriest une cause confirmee de gastrite, jouant également un rôle dans des maladies non digestives.
Objectif
Explorer le rôle deH. pylori chez les patients atteints de prurit réfractaire inexpliqué.
Méthodes
Dix sujets souffrant de prurit intense et ne réagissant pas à la thérapie conventionnelle ont été évalués. Une sérologie a été effectuée pour identifier une infection active aH. pylori. Par la suite, soit une Œsophago-gastro-duodenoscopie, soit un test respiratoire à l’urée a été pratiqué. Parmi les dix sujets, huit (8) avaient une infection active. Les dix ont reçu une antibiothérapie contreH. pylori et le degré de soulagement du prurit a été évalué par la suite.
Résultats
Parmi les huit patients souffrant d’une infection active àH. pylori, 87,5% (7/ 8) ont manifesté un certain degré de soulagement du prurit à la suite d’une triple therapie. De ce nombre, 62,5% (5/8) ont été complètement guéris et 25% (2/8) temporairement soulagés de leur prurit. Le reste, soit 12,5% ou 1/8, n’a pas réagi. Deux patients témoins n’ayant pas une infection active àH. pylori n’ont pas montré des signes de soulagement du prurit.
Conclusion
Nous avons identifié une population de patients ayant une infection active àH. pylori dont le prurit réfractaire.
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Kandyil, R., Satya, N.S. & Swerlick, R.A. Chronic pruritus associated withHelicobacter pylori . J Cutan Med Surg 6, 103–108 (2002). https://doi.org/10.1007/s10227-001-0032-y
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DOI: https://doi.org/10.1007/s10227-001-0032-y