Abstract
Background
Schwannomas of the VIIIth cranial nerve are benign tumours, with vast majority occurring in vestibular division. Rarely, they can also arise from distal branches of cochlear, superior or inferior vestibular. We review our experience with Gamma Knife radiosurgery (GKR), as first intention treatment for intracochlear (ICS) and intravestibular (IVS) schwannomas.
Methods
A total number of five patients were analysed, treated over 8 years, between June 2010 and September 2018, with Leksell Gamma Knife Perfexion or Icon (Elekta Instruments, AB, Sweden). The marginal dose prescribed was 12 Gy at a mean prescription isodose line of 61.4% (range 50–70). Clinical evaluation included auditory and facial function.
Results
The mean age was 49.9 (range 34–63). The mean follow-up period was 52.8 months (range 12–84). The mean target volume (TV) was 0.087 ml (range 0.014–0.281). The mean maximal dose received by the cochlea was 11.2 Gy (range 2.6–20.3). The mean marginal dose received by the vestibule (e.g. utricula) was 14.2 Gy (range 3.8–17.5). No patient experienced an acute or subacute clinical adverse radiation effect after GKR. Four cases had overall symptom stability. In one patient (1/5), the vertigo, which was the main clinical complain, disappeared 1 year after GKR. However, it reappeared 3 years later, with same pretherapeutic characteristics and is currently fluctuating. One patient experienced hearing decrease after GKR, during the first 12 months. This case received 11.2 Gy to the cochlea. Follow-up MRI course showed a decrease in size in four patients, and stability in one.
Conclusions
Gamma Knife radiosurgery is a valuable first intention treatment for ICS or IVS, in selected cases. Special attention should be paid for the dose delivered to the cochlea and the vestibular apparatus. Acute and subacute clinical effects are exceptional, while tumour control was achieved in all cases in our small series.
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Introduction
Schwannomas of the VIIIth cranial nerve are benign tumours, occurring usually in the cistern of the cerebello-pontine angle or in the internal auditory canal (IAC) [22]. They develop from the Schwann cells that from the myelin sheets of the nerves. They may originate anywhere within the course of the cochlea-vestibular nerves, peripheral to the glial-Schwann junction [7]. The vast majority arise in the vestibular division. Rarely, they can also arise from very distal branches of the cochlear, superior or inferior vestibular, at the level of the sensory end organs [18].
Intracochlear (ICS) and intravestibular (IVS) schwannomas may present with nonspecific symptoms. Usually, patients might experience complete loss, which might occur acutely or progressively, balance problems (dizziness, vertigo, postural instability) or tinnitus [16]. Clinical diagnosis is usually made by ENT-specific examination, including ear microscopy, audiological assessment, neuro-otological diagnosis with testing of the semi-circular canal and the otolith organs [16]. The former is classically completed by the gold standard high-resolution magnetic resonance imaging (MRI) [1].
The common management is “wait-and-scan” strategy or, in reserved cases, different surgical approaches [2, 6, 12]. There is only one study, up-to-date, reporting the use of Gamma Knife radiosurgery (GKR) for IVS [13].
The purpose of the present study was to evaluate the safety and efficacy of GKR as a first intention treatment in selected cases of ICS and IVS.
Materials and methods
Type of study
The study was designed as opened, retrospective, non-randomised. A case-report form was created since the first treated patient and prospectively filled in with the baseline and follow-up data (historical cohort analysis).
Participants
Vestibular schwannoma (VS) is one of the most frequent pathology treated in our Gamma Knife Center, accounting for almost 30% of the patients. All cases with an ICS or IVS were included in the study. A total number of five patients were further analysed, treated over of period of 8 years, between June 2010 and September 2018. The main indication for GKR was clinical and/or radiological evolutivity.
Baseline and follow-up monitoring
The baseline assessment included clinical demographic data, full clinical examination including that of the CN. Paraclinical exam included vocal and tonal audiometry, caloric testing as well as brain MRI. After GKS, patients were evaluated at 6, 12, 24, 36, 60 and 72 months, respectively, with ENT outpatient’s tests, brain MRI and neurosurgery consultation, in our office.
The auditory function was analysed by using the Gardner Robertson (GR) classification [3]. Facial function was assessed using the House-Brackmann scale [11].
Description of the GKR technique
We applied, in every case, the Leksell Model G stereotactic frame (Elekta Instruments AB, Sweden) under local anaesthesia. Afterwards, all patients underwent stereotactic MRI and bone CT for target and organs at risk definition.
During dosimetry planning, special attention was given to the dose received by the cochlea in patients with functional hearing at baseline [14]. Due to the particular anatomical location, we also defined the vestibule, as the structure that is very close anatomically to the cochlea, and which might be subjected to dose increase when limiting the dose to the cochlea, as in our previously described methodology [21].
The stereotactic MRI sequences used were T1 with and without gadolinium enhancement and T2 CISS/FIESTA without contrast, the former for a better visualisation of the cranial nerves and of the cochlear and vestibular structures [8, 9]. Bone CT routinely supplemented the neuroimaging investigation in order to correct any distortion errors that might be encountered on the MRI images. Additionally, it provided important information with regard to the bony landmarks of the internal auditory canal, as well as of the cochlea and the vestibule, important in the context of our study. Particular attention was paid to the dose received by the cochlea, due to its impact for further hearing preservation [14, 19].
Leksell Gamma Knife Perfexion had been used between June 2010 and June 2016 and the Leksell Gamma Knife ICON afterwards (Elekta Instruments, AB, Sweden) (Figs. 1 and 2).
Basic demographic data (Table 1)
The mean age in this series was 49.9 (range 34–63). The mean follow-up period was 52.8 months (range 12–84). The male to female ratio was 2 to 3. The most common symptom at discovery was hearing loss (4/5 patients), with one patient experiencing brutal hearing loss. One patient had vertigo (1/5) at initial clinical evaluation.
The corresponding GR class was 2 in two cases, 3 in one case, and 5 in two cases. No patient has facial palsy. The MRI appearance corresponded to a pure IVS in two cases, pure ILC in one case, and mixed IVS and ICS or with an additional cisternal part, each with one case.
Basic dosimetric data (Table 2)
The marginal dose prescribed was 12 Gy in all cases, at a mean prescription isodose line of 61.4% (range 50–70). The mean target volume (TV) was 0.087 ml (range 0.014–0.281). The mean prescription isodose volume (PIV) was 0.174 ml (range 0.053–0.504).
The mean maximal dose received by the cochlea was 11.2 Gy (range 2.6–20.3). The mean marginal dose received by the vestibule (e.g. utricula) was 14.2 Gy (range 3.8–17.5).
Results
Clinical follow-up
No patient experienced an acute or subacute clinical adverse radiation effect after GKR.
Four cases had overall symptom stability. In one patient (1/4), the vertigo, which was the main clinical complain, disappeared 1 year after GKR. However, it reappeared 3 years later, with the same pretherapeutic characteristics and is currently fluctuating. One patient experienced hearing decrease after GKR, during the first 12 months. This case received 11.2 Gy to the cochlea.
Radiological follow-up
Follow-up MRI course showed a decrease in size in four patients, and stability in one.
Discussion
To the best of our knowledge, this is the second study analysing the role of GKR as a first intention treatment for selected cases of ICS and IVS, after a previous report published earlier in 2011 [13]. Beside the previous, only a small number of papers have described this particular and rare pathology, in non-radiosurgical setting, in the frame of case reports or small series [10]. In our experience, we report no acute or subacute adverse radiation effects in this indication, both for ICS and for IVS, as we have previously reported in our overall series of VSs treated with GKR [21]. Symptom stability was confirmed on four out of five cases. One patient, who received 11.2 Gy to the cochlea, due to the particular anatomical location and the dosimetric conditions, reported hearing decrease during follow-up course. Tumour decrease was attained in four cases, and stability in one.
The most commonly used classification for ICS and IVS is the one proposed by Salzmann et al. [17], separating six types: intracochlear (limited to the cochlea), transmodiolar (extension to IAC via modiolus), intravestibular (vestibule, with or without extension to semi-circular canals), transmacular (vestibule, with or without extension to semi-circular canals and extension to IAC macula cribrosa), intravestibulocochlear (vestibule, with or without extension to semi-circular canals and in the cochlea), transotic ± the cerebello-pontine angle (tumour in the cochlea, and/or vestibular portion of the inner ear, extension into the middle ear). It is well known that schwann cells of the cochlear axons in the cochlear nerve are present in the modiolus, proximal to the spiral ganglion [23, 24]. In this context, a schwannoma could develop in the modiulus, present further growth, occupy the cochlear basal turn, erode the cribriform area of the IAM and spread into the vestibule.
The classical symptom is hearing loss, followed by vertigo and imbalance [1].
During the past decades, the MRI development has allowed a fine diagnosis in this particular and rare pathology. Dedicated sequences, including T2 CISS/Fiesta images, have provided detailed anatomical description and enabled early diagnosis. This was previously most probably responsible for an underestimation of the real number of cases. The most important differential diagnosis is an infectious and inflammatory process, as ICS especially could also miming this, due to the filling defect present on T2-weighted images [1].
Once diagnosed, the management of the ICL and IVS includes: wait-and-scan strategy (patients without specific complains including good level of hearing, absence of vertigo/balance issues and tumour stability) [4], surgery, or SRS and particularly GKR, due to its steep gradient, particularly necessary in this indication, due to the presence of organs at risk. The management strategy depends on the degree of symptoms and further hearing loss, tumour’s size, tumour’s increase, special concerns about the pathophysiological diagnosis (if surgery is performed) and particular comorbidities [5, 23, 24]. One has to keep in mind that surgical removal is followed by complete hearing loss, due to the transotic, translabyrinthine or transcanal labyrinthectomy accesses [15].
Radiosurgery and particularly GKR have the advantage of its minimal invasiveness. With high rates of tumour control [20] and keeping the maximal dose delivered to the cochlea below 4 Gy if the anatomical conditions will allow, one might also expect hearing preservation on a long-term basis [14, 19]. No vestibular deterioration has been seen in this small series.
Stereotactic radiosurgery is a valuable option as first-line treatment for ICS and IVS. Technically, the procedure is feasible, while prescribing low radiation doses, such as in the more classical VSs in general (e.g. 12 Gy). Grace to the steep gradient of GKR, one could also expect functional preservation in cases having pretherapeutically high level of hearing. Tumour control was achieved in all cases in our small series.
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This study was funded by Lausanne University Hospital.
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Tuleasca, C., George, M., Schiappacasse, L. et al. Gamma Knife radiosurgery for intravestibular and intracochlear schwannomas. Acta Neurochir 161, 63–67 (2019). https://doi.org/10.1007/s00701-018-3762-y
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DOI: https://doi.org/10.1007/s00701-018-3762-y