To the Editor,

We read with great interest the article published in Supportive Care in Cancer on June 29, 2024, by Ying et al. titled, “Quality of life and death anxiety among caregivers of patients with advanced cancer: The mediating effect of trait anxious personality and the moderating effect of social support” [1]. Ying et al. identified that Quality of Life (QoL) was directly related to an increased risk of death anxiety (DA) and indirectly related to DA by increasing the risk of trait anxious personality among caregivers [1]. In this study, we present a point pertaining to this study for further discussion.

Ying et al. pointed out that QoL is negatively related to DA among caregivers, and trait anxiety mediates the association between them [1]. Moreover, the study highlighted that in a cross-sectional survey using random cluster sampling, all caregivers of patients with breast, liver, bladder, brain, stomach, and lung cancers were included in the study [1]. A prior study indicated that the factors associated with DA were age, primary caregivers, adult children, treatment methods (targeted therapy and supportive therapy), and activities of daily living from bivariate analyses, showing statistical significance [2]. We believe that the treatment options vary greatly depending on the disease-causing cancer type. Additionally, other studies have highlighted the disease characteristics of brain tumors in relation to fear of cancer recurrence, a variable akin to DA [3]. This study used random sampling of various cancer types. This study aimed to examine the method of how the disease characteristics of cancer influence the results and analyze authors’ conclusions in this regard. We are particularly interested in a more detailed discussion by the authors regarding the disease-specific characteristics of cancer.

Undoubtedly, it is important to focus on DA and QoL among caregivers of patients with advanced cancer, and the study conducted by Ying et al. provided useful data in this regard. We believe that this study will contribute to effective caregiver support in caring for patients with advanced cancer.