Abstract
Depression is a frequent comorbidity of type 1 diabetes (T1D) and type 2 diabetes (T2D). Depression and diabetes are linked by a bidirectional relationship, but the underlying mechanisms are still incompletely understood. Experimental, observational and intervention studies showed that inflammatory processes contribute to the development of depression in animal models and humans. Given the high risk of morbidity and mortality in patients with the double burden of diabetes and depression, this review provides an overview of epidemiological studies that addressed the relationship between biomarkers of inflammation and depressive symptoms or depression in diabetes patients. In patients with T1D, there is some evidence that higher levels of high-sensitivity C-reactive protein (hsCRP), IL-6, IL-1 receptor antagonist (IL-1RA) and sICAM-1 may be related to depressive symptoms or (for hsCRP) lower treatment response. For T2D, hsCRP, IL-1RA, CCL2 and adiponectin or its isoforms were associated with depressive symptoms in at least two studies, whereas positive associations of IL-1β, IL-6 and IL-18 with depressive symptoms or depression were reported from single cohorts. However, the number of studies is too low for any meaningful meta-analysis. Prospective life course studies including both patients with T1D and T2D, a comprehensive assessment of systemic inflammation and repeated assessment of depressive symptoms should represent a future research priority to clarify to what extent subclinical inflammation affects the risk of depression in patients with diabetes. A better understanding of the role of inflammatory processes may help to identify subtypes of depression with partly different pathogenesis, which could have consequences with respect to therapeutic options including immunomodulation.
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Introduction
Depression is one of the most frequent comorbidities in both patients with type 1 diabetes (T1D) and type 2 diabetes (T2D). The lifetime risk of major depression in the general population has been estimated to reach 16% [1], but for individuals with diabetes, this lifetime risk is approximately twofold higher [2, 3]. Thus, depression must be considered as comorbidity of diabetes in a similar way as cardiovascular disease, neuropathy, chronic kidney disease and retinopathy.
Of note, prospective studies point towards a bidirectional relationship between depression and diabetes [4, 5]. Several potential explanations for this bidirectionality have been proposed. In addition to direct causal effects of diabetes on depression and vice versa, it is conceivable that shared risk factors for both diseases lead to associations in epidemiological studies which may not be causal [6, 7]. Whereas an activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system are mainly discussed as mechanisms contributing to the development of depression [6, 8], inflammatory processes are of particular interest in depression research not only because of their relevance in the development of T1D and T2D [6, 9, 10] but also because of their contribution to other diabetic comorbidities. In this context, cardiovascular diseases (CVD) have been studied in detail [11, 12], and recently, the first large RCT demonstrated that the risk of recurrent cardiovascular events can be reduced with an interleukin (IL)-1β inhibitor, i.e. with a purely anti-inflammatory therapy [13]. Prospective studies also indicate that different patterns of immune activation precede the onset of polyneuropathy [14, 15], chronic kidney disease [16,17,18] and retinopathy [19,20,21].
Numerous cross-sectional and prospective studies have shown that individuals with depressive symptoms or major depression have higher systemic levels of proinflammatory biomarkers of inflammation [22,23,24,25] and that higher levels of biomarkers of inflammation such as high-sensitivity C-reactive protein (hsCRP) and IL-6 are associated with a higher risk to develop depressive symptoms or depression [6, 25, 26]. However, most of these studies were community-based, whereas hardly any data are available for patients with diabetes.
In this review, we will therefore discuss what is known about the relationship between inflammation, diabetes and depression with specific focus on human studies. After an introduction of the clinical relevance of depression as diabetic comorbidity, we will briefly summarise the evidence that inflammation represents a risk factor for depression and give a detailed overview and update on epidemiological studies addressing this question in patients with diabetes. Finally, our conclusions will be linked with a concise discussion of open questions and future research priorities.
Depression and diabetes—clinically relevant comorbidities
The risk for clinical depression as well as subclinical depression is roughly doubled in people with diabetes compared to the general population [27, 28], so that the notion of depression as comorbidity of diabetes is well-established. A meta-analysis of 42 studies demonstrated that 31% of patients with diabetes reported having elevated depressive symptoms compared to 14% among individuals without diabetes. A diagnosis of clinical depression based on standardised criteria as defined by the ICD-10 (10th revision of the International Statistical Classification of Diseases and Health Related Problems) or the DSM-5 (5th edition of the Diagnostic and Statistical Manual of Mental Disorders) was also more frequent among patients with diabetes (11.4%) compared to individuals without diabetes (5.0%) [27]. A newer systematic review yielded similar results of a prevalence between 10% and 20% with clinical depression, depending on the clinical setting [29].
The reason for this high degree of comorbidity of diabetes and depression is unclear. Of note, there is evidence that elevated prevalences of depression are not uncommon in people with chronic diseases. The WHO World Health Survey summarised prevalence rates based on ICD-10 criteria for depression from 60 countries worldwide and found a significantly higher prevalence of depression in people with at least one comorbid somatic complication compared to the healthy general population (3.2%). The prevalence of depression in specific somatic diseases was 9.3% for diabetes mellitus, 15.0% for arthritis, 18.1% for angina pectoris and 18.1% for asthma [30]. A study in the USA yielded similar results [31]. The relative risk for major depression was elevated by 2.6-fold if a somatic disease was present with comorbid depression rates ranging from 7.9% in patients with heart failure to 17% in patients with end-stage renal disease [31]. These data clearly show that the presence of a chronic somatic disease is a risk factor for depression and that the comorbidity of depression and diabetes does not seem to be an exception. However, since the long-term prognosis of diabetes is highly dependent on adequate self-care behaviour, depression most likely has a more clinically relevant impact on the course of diabetes than that of other chronic conditions [32,33,34].
Given the overall high prevalence of depression in many chronic diseases, it seems reasonable to assume that elevated depression rates are partially explainable by disease-specific distress that contributes to elevated depression scores or even clinical depression in vulnerable individuals [34]. In line with this, a meta-analysis showed that depression was significantly more common in people with treated diabetes than in people with screen-detected diabetes or disturbed glucose tolerance [35]. This may indicate that the experience of having a chronic disease and treatment requirements may have been associated with depression in addition to the metabolic component of glucose intolerance.
However, further studies indicate that depression may also lead to T2D, suggesting a bidirectional relationship between depression and diabetes. As early as in the seventeenth century, Thomas Willis made the observation that prolonged sorrow lead to diabetes [36]. Meta-analyses of prospective studies were able to corroborate this early observation. Two meta-analyses showed identically that the risk to develop T2D is enhanced by 37% in individuals with depression compared to non-depressed individuals at study baseline [37, 38]. The mechanisms linking depression to future diabetes are not fully understood yet. Depression may be associated with less healthy behaviour, sedentary lifestyle and overweight. However, studies which are able to adjust the diabetes risk for lifestyle factors found that such an adjustment attenuated the association between depression and diabetes, but the association between depression and future diabetes remained still significant [4, 5]. This might indicate the presence of other factors than lifestyle as etiologically important. A meta-analysis on insulin resistance and depression showed that depression was related to insulin resistance, which might be an additional pathway mediating the link between depression and elevated diabetes risk [39]. Immune activation and inflammation could represent a second pathway because adjustment for biomarkers of inflammation (CRP and IL-6) lead to an attenuation of diabetes risk in people with depression [4]. The role of systematic levels of inflammation-related biomarkers for the link between diabetes and depression will be discussed in detail below.
From a clinical perspective, it is important to note that the WHO Health Survey indicated that comorbid depression in combination with other chronic diseases leads to a significantly larger impairment in health than other chronic diseases as comorbidities. This effect was substantially amplified in the case of comorbid depression with diabetes [30]. This is in line with other studies also reporting that the interaction between depression and diabetes resulted in a larger decrease in quality of life than the added effects of depression and diabetes alone [40].
The comorbidity of depression and diabetes has also implications for diabetes self-care behaviour. There is evidence from a meta-analysis that depression might be a barrier for effective diabetes self-care [41]. Patients with diabetes and a higher depression score were characterised by higher rates of non-adherence to oral anti-diabetic medication, less exercise, unhealthier dietary behaviour and less frequent glucose monitoring. More complex self-care behaviours like achieving and maintaining lifestyle changes were more strongly affected by depression than less complex self-care behaviours like adherence to medication [42]. Therefore, it is not surprising that there is an established link between the degree of depression and increasingly poor glycaemic control [42,43,44].
Depression in people with diabetes is also a risk factor for the occurrence of late complications and functional disabilities. In a prospective study with a 7-year follow-up the hazard ratio (HR) for macrovascular complications was more than three times higher when depressive symptoms were present in patients with diabetes at baseline [45]. For microvascular complications and functional disability, minor depression was a risk factor associated with HRs of 8.6 and 6.9, respectively. The difference between mild and more severe depression with regard to the risk of late complications was surprisingly rather small [45]. Thus, it seems that even milder forms of depression must be taken seriously in clinical practice [46]. In addition to the link with macro- and microvascular complications, mortality is also enhanced in people with the double burden of depression and diabetes with an increase of overall mortality by 46% and a cardiovascular mortality by 39% [47]. The representative National Health and Nutrition Examination Survey (NHANES) revealed a similar elevation of mortality risk in depressed people with diabetes. Mortality was 54% higher in depressed patients compared to non-depressed patients with diabetes [48]. The link with mortality was more pronounced in patients with diabetes and major compared to minor depression [48,49,50]. Lifestyle factors such as overweight, sedentary lifestyle and smoking were found to partially mediate the relationship between depression and mortality in diabetes, but after adjustment depression was still a significant predictor for mortality in diabetes [50]. This indicates that lifestyle plays an important mediating role between depression and mortality but also points towards additional factors that must be considered to explain the increased mortality rates in patients with depression.
In summary, the empirical evidence demonstrates that the comorbidity of depression and diabetes is clinically relevant because depression impairs quality of life in people with diabetes and also their diabetes self-management. In addition, depression in diabetes is associated with a less favourable prognosis regarding the risk for complications and mortality. The relationship between depression and diabetes is not fully understood. A bidirectional relationship between depression and diabetes is highly probable, since living with the chronic condition of diabetes is a risk factor for depression, but also depression represents a risk factor for future T2D. There is an urgent need to identify and characterise mechanisms and pathways that mediate and explain this relationship because only a better understanding of these links can pave the way to more effective treatment to reduce the excess burden of morbidity and mortality.
Subclinical inflammation and depression—experimental and epidemiological evidence
The aetiology of depression is multifactorial. Psychological, behavioural and social aspects have been discussed above, but it also comprises genetic, metabolic and immunological components [1, 51, 52]. From a pathophysiological perspective underlying mechanisms include the disruption of the interplay between the immune system, metabolism and the central nervous system (CNS) (e.g. altered metabolism of neurotransmitters including serotonin, dopamine and glutamate in the CNS, activation of the HPA axis, activation of the sympathetic nervous system, glucocorticoid resistance, inflammatory processes), but may also involve neurotoxic processes (alterations of neuronal plasticity) and structural changes in different areas of the brain as discussed in more detail in several excellent reviews [6, 10, 51, 53,54,55]. Here, we focus on the relevance of subclinical inflammation in this context, which may act as mediator between various risk factors and onset of depression [56] or as independent risk factor. Several lines of evidence link inflammatory processes with depression risk: (i) experimental studies in animal models and humans, (ii) observational studies of community-based or patient cohorts and (iii) intervention studies examining the efficacy of antidepressant treatment [8,9,10, 52, 53].
First, experimental studies show that immune activation leads to affective symptoms and behavioural changes in rodent models and humans that are indicative of the onset of depressive symptoms [53]. In rodent models, administration of proinflammatory cytokines (e.g. IL-1β, tumour necrosis factor-α (TNFα)) or stimulation of the innate immune system with bacterial lipopolysaccharide (LPS) leads to depression-like behaviour, which can be attenuated by administration of anti-inflammatory cytokines such as IL-10 [53]. In humans, it is known that acute infections are often associated with mood disturbances and depressive symptoms which are adaptive and reversible [10]. Similar effects can be observed when using experimental administration of LPS or following immune activation with vaccines [53, 57] and the onset of depressive symptoms is a common side effect in patients receiving interferon-α (IFNα) or IL-2 as therapy against hepatitis virus infection and cancer, respectively [53].
Of note, the association between inflammation and depression is bidirectional which needs to be considered when interpreting cross-sectional studies. Psychological stressors activate the NF-κB pathway and the Nod-like receptor pyrin containing 3 (NLRP3) inflammasome, resulting in the release of proinflammatory cytokines such as IL-1β, IL-6, IL-18 and TNFα which have been implicated in the risk of depression in experimental and epidemiological studies [58, 59]. Stress-induced alterations are not only limited to immune cells in the periphery, but also affect microglia in the CNS [60].
The second line of evidence comprises data from observational studies with cross-sectional or prospective designs. The most direct assessment of the association between inflammatory processes and the development of depression would involve measurements of an upregulation of proinflammatory biomarkers in the CNS. This is not feasible in epidemiological studies, but it should be noted that a large study using samples from the cerebral cortex of psychiatric patients found direct evidence for a link between inflammation-related gene expression patterns and a dysregulation of the HPA axis in patients with depression [61], which validates the approach to study the link between immune activation and depressive symptoms using systemic biomarkers from peripheral blood. Additionally, a recent study reported that biomarkers of inflammation measured in peripheral blood were highly correlated with biomarkers of inflammation in cerebrospinal fluid, which in turn were linked with depressive symptoms [62]. Peripheral inflammation can reach the CNS via humoral, nervous and chemical pathways, so that a correlation between peripheral and central inflammation is biologically plausible and biomarkers of subclinical inflammation in blood may at least partly reflect central inflammation.
Meta-analyses of cross-sectional studies found that individuals with depressive symptoms or depression have higher levels of several proinflammatory biomarkers than controls without depression with most consistent evidence for the acute-phase protein hsCRP and the cytokine IL-6 [22,23,24,25, 63]. Other biomarkers that showed positive associations with the presence of depressive symptoms or depression in several studies include further proinflammatory cytokines (IL-1β, IL-12, IL-18, TNFα); anti-inflammatory cytokines (IL-1 receptor antagonist (IL-1RA), IL-10); soluble forms of cytokine receptors (soluble IL-2 receptor, soluble TNF receptor 2); and chemokines (MCP-1/CCL2 [monocyte chemoattractant protein 1/C-C motif chemokine ligand 2], IL-8/CXCL8 [C-X-C motif chemokine ligand 8]) [22, 24, 63,64,65,66,67]. There appears to be a dose-response relationship between systemic levels of proinflammatory immune mediators and the severity of depression [22, 23], which could argue for a causal relationship. However, the level of adjustment for covariables differs widely between studies, and recent meta-analyses used CRP and IL-6 as examples to demonstrate that confounders such as age, sex, obesity, comorbidities, lifestyle and psychosocial factors and medication use may explain a large part of the raw effect estimated from unadjusted analysis [25, 68]. Therefore, the strength of the association between biomarker levels and depression is still unclear despite the high number of studies in this field. Additionally, as discussed above, there is a bidirectionality in the association between subclinical inflammation and depression, so that studies with a longitudinal design are required to reveal temporal and potentially causal relationships.
Of note, depression is a heterogeneous disease [51] and several studies indicated that biomarkers of inflammation are related to specific symptoms of depression which further complicates the interpretation of study results [8]. Both in the US NHANES and in the English Longitudinal Study of Ageing, higher CRP levels were independently associated with somatic symptoms of depression, but not with cognitive or emotional symptoms [69, 70].
Findings from several prospective studies corroborated these data because higher systemic levels of proinflammatory biomarkers are also associated with a higher risk of incident depressive symptoms or major depression. CRP and IL-6 are the most frequently measured biomarkers in this context, and data for CRP as risk factor of depression are more consistent than for IL-6 [25, 26]. However, risk of confounding, heterogeneity between studies and potential publication bias of both cross-sectional and prospective studies currently limit the informative value of such meta-analyses.
Finally, data from intervention studies provide a third line of evidence that subclinical inflammation and depression are linked in a clinically relevant manner. In a number of studies, biomarkers of inflammation before and after (mostly pharmacological) treatment have been related to treatment response. Individual studies and meta-analyses showed that antidepressant treatment has the potential to attenuate subclinical inflammation [71,72,73] and that subsets of patients with higher levels of proinflammatory cytokines, in particular TNFα, may have a less pronounced response to antidepressant treatment compared to patients with lower levels of these cytokines [74, 75]. However, these data were derived from heterogeneous groups of patients and specific data for patients with diabetes are not yet available.
Biomarkers of subclinical inflammation and depression in patients with diabetes
Despite the high proportion of patients with diabetes affected by depressive symptoms or depression, the number of studies addressing the association between biomarkers of inflammation and depression specifically in patients with T1D [76,77,78,79,80] or T2D [76,77,78,79,80,81,82,83] is relatively small. Some of these studies addressed only one diabetes type [81,82,83], whereas others compared patients with T1D and T2D in the same cohorts [76,77,78,79,80]. Most of these studies were cross-sectional [76, 78, 79, 81,82,83], while only two studies had a longitudinal or prospective design [77, 80]. Of note, all studies adjusted for multiple confounders to reduce the risk of bias.
Table 1 provides an overview of studies on biomarkers of inflammation and depression in patients with T1D. In the SEARCH for Diabetes in Youth Study comprising children and adolescents with T1D, higher CRP was associated with depression, but this association was not significant in the adjusted model [76]. Higher levels of IL-6 and soluble intercellular adhesion molecule 1 (sICAM-1) were associated with depressive symptoms in adult patients with recent-onset T1D from the German Diabetes Study, but the association for IL-6 was attenuated by adjustment for confounders [78]. The analysis of baseline data from two intervention studies in T1D patients with longer disease duration aiming at reducing diabetes distress and depressive symptoms showed that higher levels of hsCRP and IL-1RA were associated with depressive symptoms after full adjustment [79]. However, when these patients were followed up for 12 months, changes in neither biomarker nor in any of the others included in the study (IL-6, IL-18, CCL2, adiponectin) were linked to reductions in depressive symptoms, and baseline biomarker levels were also not related to treatment response [80]. In contrast, higher hsCRP levels were linked to less pronounced reduction of depressive symptoms in the Diabetes and Depression study in which adults patients with T1D were randomised to diabetes-specific group cognitive behavioural therapy or sertraline treatment and followed-up for 15 months [77]. Taken together, there is preliminary evidence that higher levels of hsCRP, IL-6, IL-1RA and sICAM-1 may be related to depressive symptoms or (for hsCRP) lower treatment response, but overall not enough studies are available and data are too inconsistent to draw any sound conclusions for T1D.
Table 2 summarises the available data for associations between biomarkers of inflammation and depressive symptoms or depression in patients with T2D. While no association between biomarkers and depression were found in the SEARCH for Diabetes in Youth Study [76], higher IL-6 levels were linked with depression in a small group of participants from the Health, Ageing and Body Composition study [81]. Higher hsCRP was related to major depression in the Diabetes Distress and Care Registry at Tenri in the age- and sex-adjusted analysis, but not upon further adjustment [82]. A large panel of 11 biomarkers of inflammation were investigated in the South London Diabetes Study, which found positive associations of hsCRP, IL-1β, IL-1RA, CCL2 and white blood cell count with depressive symptoms in the fully adjusted model [83]. In the German Diabetes Study, higher hsCRP and a higher ratio of high molecular weight (HMW)/total adiponectin was associated with depressive symptoms [78] in patients with recent-onset T2D, whereas higher hsCRP, IL-18 and IL-1RA as well as lower adiponectin levels were found associated with depressive symptoms in patients with a longer duration of T2D [79]. In the latter study cohort, reductions in depressive symptoms over 12 months were related to reductions in hsCRP, IL-18 and IL-1RA and higher baseline CCL2 levels were associated with lower treatment response [80]. The second longitudinal study included only hsCRP and found no link between baseline levels and changes in depressive symptoms [77]. In summary, hsCRP, IL-1RA, CCL2 and adiponectin or its isoforms were associated with depressive symptoms in at least two study samples, whereas positive associations of IL-1β, IL-6 and IL-18 with depressive symptoms or depression were reported from single cohorts. Although there are more studies on associations between inflammation and depression for T2D compared to T1D, the number of studies is too low to explain the heterogeneity of findings and precludes any meaningful meta-analysis. Overall, the cumulative evidence is still weak, and positive findings from the aforementioned studies need further replication.
In the context of T2D, data from population-based studies are also of interest, if they consider the impact of diabetes type in stratified analyses or by testing interactions by diabetes type. The Maastricht Study is a population-based study with an oversampling of individuals with T2D. In a study sample in which 29% of all participants had a diagnosis of T2D, a sum score for low-grade inflammation containing CRP, TNFα, serum amyloid A (SAA), sICAM, IL-6 and IL-8/CXCL8 was positively associated with depressive symptoms and depressive disorder without significant interaction by diabetes status, indicating that associations did not differ between individuals without and with T2D [84].
Given the data from study cohorts with T1D and T2D, it is not possible to conclude if associations between biomarkers of inflammation and depressive symptoms differ between community or population-based studies and patients with diabetes. There appears a large overlap of depression-related biomarkers of inflammation between both types of study samples pointing towards an upregulation of acute-phase proteins, proinflammatory cytokines, chemokines and markers of vascular inflammation in patients with depressive symptoms or depression. With respect to anti-inflammatory biomarkers, systemic levels of IL-1RA have been found positively associated with depressive symptoms and depression in individuals without and with diabetes, which may appear counterintuitive. However, this finding is in line with other observations that higher IL-1RA levels are associated with higher risk of T2D, cardiovascular disease and other diabetic comorbidities [14, 85, 86]. Higher IL-1RA levels in individuals at higher cardiometabolic risk may reflect IL-1β-related processes (IL-1β can induce IL-1RA as endogenous inhibitor) or may be caused by other proinflammatory and/or metabolic stimuli that increase cardiometabolic risk [86].
It is interesting that the few studies comprising both patients with T1D and T2D found differences in the associations between biomarkers of inflammation and depressive symptoms. Some studies found more evidence for associations between biomarkers of inflammation and depressive symptoms in T2D compared with T1D [78,79,80], whereas one study identified associations between hsCRP and treatment response in T1D only [77]. Such differences may be related to differences in the inflammatory contribution to T1D vs T2D [52] and are in line with other recent data pointing towards differences in the associations of inflammation with diabetic comorbidities between both diabetes types for other diabetic complications including DSPN and cardiovascular autonomic neuropathy [87,88,89].
Conclusions and outlook
The contribution of inflammatory processes to the development of depressive symptoms has been clearly demonstrated by experimental studies using animal models, clinical studies involving the administration of proinflammatory cytokines, epidemiological studies linking biomarkers of inflammation with depression and finally, treatment studies pointing towards an interaction between inflammatory status and treatment response [53]. However, most of these studies did not consider the potential relevance of diabetes for the relationship between subclinical inflammation and depression. Subclinical inflammation is most likely important as shared biological pathway predisposing to both diabetes and depression, but also represents a modifiable risk factor for the development of depression and other comorbidities in patients with diabetes.
Although subclinical inflammation has been implicated as an important pathomechanism in patients with the double burden of diabetes and depression [6, 52], this issue remains largely unexplored because of the scarcity of relevant studies. Additionally, the majority of studies in patients with diabetes have a cross-sectional design, allowing only correlational analyses of the association between biomarkers of inflammation and depression status. This is an important limitation given the bidirectional association between inflammation and depression and because of higher risk for residual confounding. Even longitudinal studies are based on usually only two examinations (baseline and one follow-up) and thus represent random snapshots, whereas the complexity of onset and remission of depression would require a life course approach with multiple assessments of risk factors and outcomes. With respect to outcomes, more clarity and precision in the terminology with respect to depressive symptoms, depressive disorders as psychiatric diagnosis and diabetes distress would help to better compare results from different studies.
From the mechanistic perspective, it is important to note that even studies in community- and population-based samples are often are limited to few biomarkers of inflammation. Reliable evidence for associations between subclinical inflammation and depression from meta-analyses is only available for hsCRP and IL-6 [22,23,24,25], which do not reflect the complexity of potentially relevant immunological mechanisms. Moreover, only few studies considered the impact of diabetes type [76,77,78,79,80], although the underlying pathomechanisms leading not only to T1D and T2D in the first place, but also to later comorbidities and complications may at least in part differ [90, 91]. Thus, prospective life course studies including both patients with T1D and T2D, a comprehensive assessment of systemic inflammation and repeated assessment of depressive symptoms should represent a research priority in order to address the question to what extent subclinical inflammation affects the risk of depression in patients with diabetes and if findings are specific for or shared between both diabetes types [51].
The clinical benefit of further studies in this field could comprise more individualised treatment strategies. A better understanding of the role of subclinical inflammation may help to identify subtypes of depression with partly different pathogenesis, which would have consequences with respect to therapeutic options, if different modifiable risk factors or pharmacological targets could be validated (e.g. immunomodulation for subgroups of patients) [8, 73]. This could in particular help people with treatment-resistant depression [66]. It has been hypothesised that immunomodulation may help to target upstream mechanisms in the aetiology of depression rather than downstream effects such as changed neurotransmitter levels, which holds promise for disease modification rather than treatment of symptoms [93]. In order to estimate the clinical relevance of immunomodulation, randomised clinical trials using anti-inflammatory treatment, most likely in combination with cognitive-behavioural therapy and/or antidepressants, will be another research priority. One challenge for such approaches consists in defining immunomodulating treatments (i.e. type of immunomodulating agent, dosage, timing of treatment) that are effective to prevent/treat depressive symptoms but do not compromise immune defence mechanisms [10]. It is conceivable that immunomodulation may even have adverse effects in patients without increased inflammation, so that the interaction of anti-inflammatory therapy as add-on to an antidepressant with baseline inflammation (e.g. hsCRP levels > 3 mg/l ) is currently being investigated in randomised controlled trials [94]. Since patients with diabetes and depression are at higher risk of other microvacular and macrovascular complications, effective forms of immunomodulation may also address several public health burdens simultaneously and help to reduce overall morbidity and mortality. Of note, most environmental risk factors for T2D, depression and other comorbidities (e.g. diet, obesity, physical inactivity, psychosocial stress, early life adversity) are proinflammatory, but the potential health benefits of lifestyle-based immunomodulation still appears underappreciated [56, 95].
Regarding further research challenges and priorities, the improvement of neuroimaging methods to assess pre-existing inflammation and potential effects of novel treatment approaches on inflammation and brain activity with respect to depression would be timely and valuable. While genetic studies so far did not provide evidence that inflammatory processes are involved in the aetiology of depression [95], it remains possible and biologically plausible that a range of environmental and behavioural factors affect epigenetic processes. Long-lasting epigenetic alterations can permanently modify gene expression patterns and thus influence subclinical inflammation and risk of depression.
In conclusion, subclinical inflammation and depressive symptoms appear tightly interrelated. Depression is a common comorbidity of diabetes, but epidemiological studies addressing the relationship between subclinical inflammation and depression specifically in patients with diabetes are scarce. There is preliminary evidence that inflammation-related biomarkers are associated with depressive symptoms in patients with diabetes in cross-sectional and longitudinal studies. Assessment of subclinical inflammation may help to identify subtypes of depression, and immunomodulating treatment could support cognitive behavioural therapy and antidepressant treatment in particular in patients who respond poorly to current treatment options. Immunomodulation may also hold promise for the prevention of further diabetic comorbidities that characterise the poor prognosis of patients with the double burden of diabetes and depression.
References
Kupfer DJ, Frank E, Phillips ML (2012) Major depressive disorder: new clinical, neurobiological, and treatment perspectives. Lancet 379:1045–1055. https://doi.org/10.1016/S0140-6736(11)60602-8
Pouwer F, Kupper N, Adriaanse MC (2010) Does emotional stress cause type 2 diabetes mellitus? A review from the European depression in diabetes (EDID) research consortium. Discov Med 9:112–118
Pouwer F (2017) Depression: a common and burdensome complication of diabetes that warrants the continued attention of clinicians, researchers and healthcare policy makers. Diabetologia 60:30–34. https://doi.org/10.1007/s00125-016-4154-6
Golden SH, Lazo M, Carnethon M, Bertoni AG, Schreiner PJ, Diez Roux AV, Lee HB, Lyketsos C (2008) Examining a bidirectional association between depressive symptoms and diabetes. JAMA 299:2751–2759. https://doi.org/10.1001/jama.299.23.2751
Pan A, Lucas M, Sun Q, van Dam RM, Franco OH, Manson JE, Willett WC, Ascherio A, Hu FB (2010) Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med 170:1884–1891. https://doi.org/10.1001/archinternmed.2010.356
Stuart MJ, Baune BT (2012) Depression and type 2 diabetes: inflammatory mechanisms of a psychoneuroendocrine co-morbidity. Neurosci Biobehav Rev 36:658–676. https://doi.org/10.1016/j.neubiorev.2011.10.001
Tabák AG, Akbaraly TN, Batty GD, Kivimäki M (2014) Depression and type 2 diabetes: a causal association? Lancet Diabetes Endocrinol 2:236–245. https://doi.org/10.1016/S2213-8587(13)70139-6
Furtado M, Katzman MA (2015) Examining the role of neuroinflammation in major depression. Psychiatry Res 229:27–36. https://doi.org/10.1016/j.psychres.2015.06.009
Korczak DJ, Pereira S, Koulajian K, Matejcek A, Giacca A (2011) Type 1 diabetes mellitus and major depressive disorder: evidence for a biological link. Diabetologia 54:2483–2493. https://doi.org/10.1007/s00125-011-2240-3
Miller AH, Raison CL (2016) The role of inflammation in depression: from evolutionary imperative to modern treatment target. Nat Rev Immunol 16:22–34. https://doi.org/10.1038/nri.2015.5
Herder C, Dalmas E, Böni-Schnetzler M, Donath MY (2015) The IL-1 pathway in type 2 diabetes and cardiovascular complications. Trends Endocrinol Metab 26:551–563. https://doi.org/10.1016/j.tem.2015.08.001
Bäck M, Hansson GK (2015) Anti-inflammatory therapies for atherosclerosis. Nat Rev Cardiol 12:199–211. https://doi.org/10.1038/nrcardio.2015.5
Ridker PM, Everett BM, Thuren T, Mac-Fadyen JG, Chang WH, Ballantyne C, Fonseca F, Nicolau J, Koenig W, Anker SD, Kastelein JJP, Cornel JH, Pais P, Pella D, Genest J, Cifkova R, Lorenzatti A, Forster T, Kobalava Z, Vida-Simiti L, Flather M, Shimokawa H, Ogawa H, Dellborg M, Rossi PRF, Troquay RPT, Libby P, Glynn RJ, CANTOS Trial Group (2017) Antiinflammatory therapy with canakinumab for atherosclerotic disease. N Engl J Med 377:1119–1131. https://doi.org/10.1056/NEJMoa1707914
Herder C, Kannenberg JM, Huth C, Carstensen-Kirberg M, Rathmann W, Koenig W, Heier M, Püttgen S, Thorand B, Peters A, Roden M, Meisinger C, Ziegler D (2017) Proinflammatory cytokines predict the incidence and progression of distal sensorimotor polyneuropathy: KORA F4/FF4 study. Diabetes Care 40:569–576. https://doi.org/10.2337/dc16-2259
Herder C, Kannenberg JM, Carstensen-Kirberg M, Strom A, Bönhof GJ, Rathmann W, Huth C, Koenig W, Heier M, Krumsiek J, Peters A, Meisinger C, Roden M, Thorand B, Ziegler D (2018) A systemic inflammatory signature reflecting crosstalk between innate and adaptive immunity is associated with incident polyneuropathy: KORA F4/FF4 study. Diabetes 67:2434–2442. https://doi.org/10.2337/db18-0060
Donate-Correa J, Martín-Núñez E, Muros-de-Fuentes M, Mora-Fernández C, Navarro-González JF (2015) Inflammatory cytokines in diabetic nephropathy. J Diabetes Res 2015:948417. https://doi.org/10.1155/2015/948417
Zoccali C, Vanholder R, Massy ZA, Ortiz A, Sarafidis P, Dekker FW, Fliser D, Fouque D, Heine GH, Jager KJ, Kanbay M, Mallamaci F, Parati G, Rossignol P, Wiecek A, London G, European Renal and Cardiovascular Medicine (EURECA-m) Working Group of the European Renal Association – European Dialysis Transplantation Association (ERA-EDTA) (2017) The systemic nature of CKD. Nat Rev Nephrol 13:344–358. https://doi.org/10.1038/nrneph.2017.52
Colhoun HM, Marcovecchio ML (2018) Biomarkers of diabetic kidney disease. Diabetologia 61:996–1011. https://doi.org/10.1007/s00125-018-4567-5
Simó-Servat O, Simó R, Hernández C (2016) Circulating biomarkers of diabetic retinopathy: an overview based on physiopathology. J Diabetes Res 2016:5263798. https://doi.org/10.1155/2016/5263798
Vujosevic S, Simó R (2017) Local and systemic inflammatory biomarkers of diabetic retinopathy: an integrative approach. Invest Ophthalmol Vis Sci 58:BIO68–BIO75. https://doi.org/10.1167/iovs.17-21769
Rübsam A, Parikh S, Fort PE (2018) Role of inflammation in diabetic retinopathy. Int J Mol Sci 19:942. https://doi.org/10.3390/ijms19040942
Howren MB, Lamkin DM, Suls J (2009) Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom Med 71:171–186. https://doi.org/10.1097/PSY.0b013e3181907c1b
Hiles SA, Baker AL, de Malmanche T, Attia J (2012) A meta-analysis of differences in IL-6 and IL-10 between people with and without depression: exploring the causes of heterogeneity. Brain Behav Immun 26:1180–1188. https://doi.org/10.1016/j.bbi.2012.06.001
Haapakoski R, Mathieu J, Ebmeier KP, Alenius H, Kivimäki M (2015) Cumulative meta-analysis of interleukins 6 and 1β, tumour necrosis factor α and C-reactive protein in patients with major depressive disorder. Brain Behav Immun 49:206–215. https://doi.org/10.1016/j.bbi.2015.06.001
Smith KJ, Au B, Ollis L, Schmitz N (2018) The association between C-reactive protein, interleukin-6 and depression among older adults in the community: a systematic review and meta-analysis. Exp Gerontol 102:109–132. https://doi.org/10.1016/j.exger.2017.12.005
Valkanova V, Ebmeier KP, Allan CL (2013) CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J Affect Disord 150:736–744. https://doi.org/10.1016/j.jad.2013.06.004
Anderson RJ, Freedland KE, Clouse RE, Lustman PJ (2001) The prevalence of comorbid depression in adults with diabetes: a meta-analysis. Diabetes Care 24:1069–1078
Kruse J, Schmitz N, Thefeld W (2003) On the association between diabetes and mental disorders in a community sample: results from the German National Health Interview and examination survey. Diabetes Care 26:1841–1846
Roy T, Lloyd CE (2012) Epidemiology of depression and diabetes: a systematic review. J Affect Disord 142(Suppl):S8–S21. https://doi.org/10.1016/S0165-0327(12)70004-6
Moussavi S, Chatterji S, Verdes E, Tandon A, Patel V, Ustun B (2007) Depression, chronic diseases, and decrements in health: results from the world health surveys. Lancet 370:851–858
Egede LE (2007) Major depression in individuals with chronic medical disorders: prevalence, correlates and association with health resource utilization, lost productivity and functional disability. Gen Hosp Psychiatry 29:409–416
Surwit R, Schneider M, Feinglos M (1992) Stress and diabetes mellitus. Diabetes Care 15:1413–1420
Kulzer B (2005) Depression—an important obstruction to the treatment of diabetes; article in German. MMW Fortschr Med 147:37–40
Snoek FJ, Bremmer MA, Hermanns N (2015) Constructs of depression and distress in diabetes: time for an appraisal. Lancet Diabetes Endocrinol 3:450–460. https://doi.org/10.1016/S2213-8587(15)00135-7
Nouwen A, Winkley K, Twisk J, Lloyd CE, Peyrot M, Ismail K, Pouwer F, European Depression in Diabetes (EDID) Research Consortium (2010) Type 2 diabetes mellitus as a risk factor for the onset of depression: a systematic review and meta-analysis. Diabetologia 53:2480–2486. https://doi.org/10.1007/s00125-010-1874-x
Willis T (1675) Pharmaceutice rationalis sive diabtriba de medicamentorum operantionibus in humano corpore, Oxford
Knol MJ, Twisk JW, Beekman AT, Heine RJ, Snoek FJ, Pouwer F (2006) Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia 49:837–345
Rotella F, Mannucci E (2013) Diabetes mellitus as a risk factor for depression. A meta-analysis of longitudinal studies. Diabetes Res Clin Pract 99:98–104. https://doi.org/10.1016/j.diabres.2012.11.022
Kan C, Silva N, Golden SH, Rajala U, Timonen M, Stahl D, Ismail K (2013) A systematic review and meta-analysis of the association between depression and insulin resistance. Diabetes Care 36:480–489. https://doi.org/10.2337/dc12-1442 Erratum in: Diabetes Care 2013;36:1429
Goldney RD, Phillips PJ, Fisher LJ, Wilson DH (2004) Diabetes, depression, and quality of life: a population study. Diabetes Care 27:1066–1070
Gonzalez JS, Peyrot M, McCarl LA, Collins EM, Serpa L, Mimiaga MJ, Safren SA (2008) Depression and diabetes treatment nonadherence: a meta-analysis. Diabetes Care 31:2398–2403. https://doi.org/10.2337/dc08-1341
Ciechanowski PS, Katon WJ, Russo JE, Hirsch IB (2003) The relationship of depressive symptoms to symptom reporting, self-care and glucose control in diabetes. Gen Hosp Psychiatry 25:246–252
Lustman PJ, Anderson RJ, Freedland KE, de Groot M, Carney RM, Clouse RE (2000) Depression and poor glycemic control: a meta-analytic review of the literature. Diabetes Care 23:934–942
Schmitt A, Gahr A, Hermanns N, Kulzer B, Huber J, Haak T (2013) The diabetes self-management questionnaire (DSMQ): development and evaluation of an instrument to assess diabetes self-care activities associated with glycaemic control. Health Qual Life Outcomes 11:138. https://doi.org/10.1186/1477-7525-11-138
Black SA, Markides KS, Ray LA (2003) Depression predicts increased incidence of adverse health outcomes in older Mexican Americans with type 2 diabetes. Diabetes Care 26:2822–2828
Schmitz N, Gariépy G, Smith KJ, Clyde M, Malla A, Boyer R, Strychar I, Lesage A, Wang J (2014) Recurrent subthreshold depression in type 2 diabetes: an important risk factor for poor health outcomes. Diabetes Care 37:970–978. https://doi.org/10.2337/dc13-1832
van Dooren FE, Schram MT, Schalkwijk CG, Stehouwer CD, Henry RM, Dagnelie PC, Schaper NC, van der Kallen CJ, Koster A, Sep SJ, Denollet J, Verhey FR, Pouwer F (2016) Associations of low grade inflammation and endothelial dysfunction with depression—the Maastricht study. Brain Behav Immun 56:390–396. https://doi.org/10.1016/j.bbi.2016.03.004
Zhang X, Norris SL, Gregg EW, Cheng YJ, Beckles G, Kahn HS (2005) Depressive symptoms and mortality among persons with and without diabetes. Am J Epidemiol 161:652–660
Egede LE (2005) Effect of depression on self-management behaviors and health outcomes in adults with type 2 diabetes. Curr Diabetes Rev 1:235–243
Katon W, Fan MY, Unützer J, Taylor J, Pincus H, Schoenbaum M (2008) Depression and diabetes: a potentially lethal combination. J Gen Intern Med 23:1571–1575. https://doi.org/10.1007/s11606-008-0731-9
Holt RI, de Groot M, Lucki I, Hunter CM, Sartorius N, Golden SH (2014) NIDDK international conference report on diabetes and depression: current understanding and future directions. Diabetes Care 37:2067–2077. https://doi.org/10.2337/dc13-2134
Moulton CD, Pickup JC, Ismail K (2015) The link between depression and diabetes: the search for shared mechanisms. Lancet Diabetes Endocrinol 3:461–471. https://doi.org/10.1016/S2213-8587(15)00134-5
Dantzer R, O'Connor JC, Freund GG, Johnson RW, Kelley KW (2008) From inflammation to sickness and depression: when the immune system subjugates the brain. Nat Rev Neurosci 9:46–56
Ho N, Sommers MS, Lucki I (2013) Effects of diabetes on hippocampal neurogenesis: links to cognition and depression. Neurosci Biobehav Rev 37:1346–1362. https://doi.org/10.1016/j.neubiorev.2013.03.010
Han QQ, Yu J (2014) Inflammation: a mechanism of depression? Neurosci Bull 30:515–523. https://doi.org/10.1007/s12264-013-1439-3
Berk M, Williams LJ, Jacka FN, O'Neil A, Pasco JA, Moylan S, Allen NB, Stuart AL, Hayley AC, Byrne ML, Maes M (2013) So depression is an inflammatory disease, but where does the inflammation come from? BMC Med 11:200. https://doi.org/10.1186/1741-7015-11-200
Kuhlman KR, Robles TF, Dooley LN, Boyle CC, Haydon MD, Bower JE (2018) Within-subject associations between inflammation and features of depression: using the flu vaccine as a mild inflammatory stimulus. Brain Behav Immun 69:540–547. https://doi.org/10.1016/j.bbi.2018.02.001
Kaufmann FN, Costa AP, Ghisleni G, Diaz AP, Rodrigues ALS, Peluffo H, Kaster MP (2017) NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings. Brain Behav Immun 64:367–383. https://doi.org/10.1016/j.bbi.2017.03.002
Franklin TC, Xu C, Duman RS (2018) Depression and sterile inflammation: essential role of danger associated molecular patterns. Brain Behav Immun 72:2–13. https://doi.org/10.1016/j.bbi.2017.10.025
Stein DJ, Naudé PJ, Berk M (2018) Stress, depression, and inflammation: molecular and microglial mechanisms. Biol Psychiatry 83:5–6. https://doi.org/10.1016/j.biopsych.2017.10.025
Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP, CommonMind Consortium; PsychENCODE Consortium; iPSYCH-BROAD Working Group, Horvath S, Geschwind DH (2018) Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science 359:693–697. https://doi.org/10.1126/science.aad6469
Felger JC, Haroon E, Patel TA, Goldsmith DR, Wommack EC, Woolwine BJ, Le NA, Feinberg R, Tansey MG, Miller AH (2018) What does plasma CRP tell us about peripheral and central inflammation in depression? Mol Psychiatry 2018. https://doi.org/10.1038/s41380-018-0096-3
Liu Y, Ho RC, Mak A (2012) Interleukin (IL)-6, tumour necrosis factor alpha (TNF-α) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J Affect Disord 139:230–239. https://doi.org/10.1016/j.jad.2011.08.003
Milaneschi Y, Corsi AM, Penninx BW, Bandinelli S, Guralnik JM, Ferrucci L (2009) Interleukin-1 receptor antagonist and incident depressive symptoms over 6 years in older persons: the InCHIANTI study. Biol Psychiatry 65:973–978. https://doi.org/10.1016/j.biopsych.2008.11.011
Eyre HA, Air T, Pradhan A, Johnston J, Lavretsky H, Stuart MJ, Baune BT (2016) A meta-analysis of chemokines in major depression. Prog Neuro-Psychopharmacol Biol Psychiatry 68:1–8. https://doi.org/10.1016/j.pnpbp.2016.02.006
Köhler CA, Freitas TH, Maes M, de Andrade NQ, Liu CS, Fernandes BS, Stubbs B, Solmi M, Veronese N, Herrmann N, Raison CL, Miller BJ, Lanctôt KL, Carvalho AF (2017) Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies. Acta Psychiatr Scand 135:373–387. https://doi.org/10.1111/acps.12698
Leighton SP, Nerurkar L, Krishnadas R, Johnman C, Graham GJ, Cavanagh J (2018) Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis. Mol Psychiatry 23:48–58. https://doi.org/10.1038/mp.2017.205
Horn SR, Long MM, Nelson BW, Allen NB, Fisher PA, Byrne ML (2018) Replication and reproducibility issues in the relationship between C-reactive protein and depression: a systematic review and focused meta-analysis. Brain Behav Immun 73:85–114. https://doi.org/10.1016/j.bbi.2018.06.016
Jokela M, Virtanen M, Batty GD, Kivimäki M (2016) Inflammation and specific symptoms of depression. JAMA Psychiatry 73:87–88. https://doi.org/10.1001/jamapsychiatry.2015.1977
White J, Kivimäki M, Jokela M, Batty GD (2017) Association of inflammation with specific symptoms of depression in a general population of older people: the English longitudinal study of ageing. Brain Behav Immun 61:27–30. https://doi.org/10.1016/j.bbi.2016.08.012
Hannestad J, DellaGioia N, Bloch M (2011) The effect of antidepressant medication treatment on serum levels of inflammatory cytokines: a meta-analysis. Neuropsychopharmacology 36:2452–2459. https://doi.org/10.1038/npp.2011.132
Hiles SA, Baker AL, de Malmanche T, Attia J (2012) Interleukin-6, C-reactive protein and interleukin-10 after antidepressant treatment in people with depression: a meta-analysis. Psychol Med 42:2015–2026. https://doi.org/10.1017/S0033291712000128
Baumeister D, Ciufolini S, Mondelli V (2016) Effects of psychotropic drugs on inflammation: consequence or mediator of therapeutic effects in psychiatric treatment? Psychopharmacology 233:1575–1589. https://doi.org/10.1007/s00213-015-4044-5
Strawbridge R, Arnone D, Danese A, Papadopoulos A, Herane Vives A, Cleare AJ (2015) Inflammation and clinical response to treatment in depression: a meta-analysis. Eur Neuropsychopharmacol 25:1532–1543. https://doi.org/10.1016/j.euroneuro.2015.06.007
Haroon E, Daguanno AW, Woolwine BJ, Goldsmith DR, Baer WM, Wommack EC, Felger JC, Miller AH (2018) Antidepressant treatment resistance is associated with increased inflammatory markers in patients with major depressive disorder. Psychoneuroendocrinology 95:43–49. https://doi.org/10.1016/j.psyneuen.2018.05.026
Hood KK, Lawrence JM, Anderson A, Bell R, Dabelea D, Daniels S, Rodriguez B, Dolan LM, SEARCH for Diabetes in Youth Study Group (2012) Metabolic and inflammatory links to depression in youth with diabetes. Diabetes Care 35:2443–2446. https://doi.org/10.2337/dc11-2329
Zahn D, Herpertz S, Albus C, Hermanns N, Hiemke C, Hiller W, Kronfeld K, Kruse J, Kulzer B, Müller MJ, Ruckes C, Petrak F (2016) hs-CRP predicts improvement in depression in patients with type 1 diabetes and major depression undergoing depression treatment: results from the diabetes and depression (DAD) study. Diabetes Care 39:e171–e173. https://doi.org/10.2337/dc16-0710
Herder C, Fürstos JF, Nowotny B, Begun A, Strassburger K, Müssig K, Szendroedi J, Icks A, Roden M, GDS group (2017) Associations between inflammation-related biomarkers and depressive symptoms in individuals with recently diagnosed type 1 and type 2 diabetes. Brain Behav Immun 61:137–145. https://doi.org/10.1016/j.bbi.2016.12.025
Herder C, Schmitt A, Budden F, Reimer A, Kulzer B, Roden M, Haak T, Hermanns N (2018) Association between pro- and anti-inflammatory cytokines and depressive symptoms in patients with diabetes—potential differences by diabetes type and depression scores. Transl Psychiatry 7:1. https://doi.org/10.1038/s41398-017-0009-2
Herder C, Schmitt A, Budden F, Reimer A, Kulzer B, Roden M, Haak T, Hermanns N (2018) Longitudinal associations between biomarkers of inflammation and changes in depressive symptoms in patients with type 1 and type 2 diabetes. Psychoneuroendocrinology 91:216–225. https://doi.org/10.1016/j.psyneuen.2018.02.032
Doyle TA, de Groot M, Harris T, Schwartz F, Strotmeyer ES, Johnson KC, Kanaya A (2013) Diabetes, depressive symptoms, and inflammation in older adults: results from the health, aging, and body composition study. J Psychosom Res 75:419–424. https://doi.org/10.1016/j.jpsychores.2013.08.006
Hayashino Y, Mashitani T, Tsujii S, Ishii H, Diabetes Distress and Care Registry at Tenri Study Group (2014) Elevated levels of hs-CRP are associated with high prevalence of depression in Japanese patients with type 2 diabetes: the diabetes distress and care registry at Tenri (DDCRT 6). Diabetes Care 37:2459–2465. https://doi.org/10.2337/dc13-2312
Laake JP, Stahl D, Amiel SA, Petrak F, Sherwood RA, Pickup JC, Ismail K (2014) The association between depressive symptoms and systemic inflammation in people with type 2 diabetes: findings from the South London diabetes study. Diabetes Care 37:2186–2192. https://doi.org/10.2337/dc13-2522
van Dooren FE, Nefs G, Schram MT, Verhey FR, Denollet J, Pouwer F (2013) Depression and risk of mortality in people with diabetes mellitus: a systematic review and meta-analysis. PLoS One 8:e57058. https://doi.org/10.1371/journal.pone.0057058
Herder C, Brunner EJ, Rathmann W, Strassburger K, Tabák AG, Schloot NC, Witte DR (2009) Elevated levels of the anti-inflammatory interleukin-1 receptor antagonist precede the onset of type 2 diabetes: the Whitehall II study. Diabetes Care 32:421–423. https://doi.org/10.2337/dc08-1161
Herder C, de Las Heras Gala T, Carstensen-Kirberg M, Huth C, Zierer A, Wahl S, Sudduth-Klinger J, Kuulasmaa K, Peretz D, Ligthart S, Bongaerts BWC, Dehghan A, Ikram MA, Jula A, Kee F, Pietilä A, Saarela O, Zeller T, Blankenberg S, Meisinger C, Peters A, Roden M, Salomaa V, Koenig W, Thorand B (2017) Circulating levels of interleukin 1-receptor antagonist and risk of cardiovascular disease: meta-analysis of six population-based cohorts. Arterioscler Thromb Vasc Biol 37:1222–1227. https://doi.org/10.1161/ATVBAHA.117.309307
Schamarek I, Herder C, Nowotny B, Carstensen-Kirberg M, Straßburger K, Nowotny P, Strom A, Püttgen S, Müssig K, Szendroedi J, Roden M, Ziegler D, German Diabetes Study Group (2016) Adiponectin, markers of subclinical inflammation and nerve conduction in individuals with recently diagnosed type 1 and type 2 diabetes. Eur J Endocrinol 174:433–443. https://doi.org/10.1530/EJE-15-1010
Herder C, Schamarek I, Nowotny B, Carstensen-Kirberg M, Straßburger K, Nowotny P, Kannenberg JM, Strom A, Püttgen S, Müssig K, Szendroedi J, Roden M, Ziegler D, German Diabetes Study Group (2017) Inflammatory markers are associated with cardiac autonomic dysfunction in recent-onset type 2 diabetes. Heart 103:63–70. https://doi.org/10.1136/heartjnl-2015-309181
Bönhof GJ, Herder C, Strom A, Papanas N, Roden M, Ziegler D (2018, 2018) Emerging biomarkers, tools, and treatments for diabetic polyneuropathy. Endocr Rev 40:153–192. https://doi.org/10.1210/er.2018-00107
Schloot NC, Pham MN, Hawa MI, Pozzilli P, Scherbaum WA, Schott M, Kolb H, Hunter S, Schernthaner G, Thivolet C, Seissler J, Leslie RD, Action LADA Group (2016) Inverse relationship between organ-specific autoantibodies and systemic immune mediators in type 1 diabetes and type 2 diabetes: Action LADA 11. Diabetes Care 39:1932–1939. https://doi.org/10.2337/dc16-0293
Leslie RD, Palmer J, Schloot NC, Lernmark A (2016) Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment. Diabetologia 59:13–20. https://doi.org/10.1007/s00125-015-3789-z
Shariq AS, Brietzke E, Rosenblat JD, Barendra V, Pan Z, McIntyre RS (2018) Targeting cytokines in reduction of depressive symptoms: a comprehensive review. Prog Neuro-Psychopharmacol Biol Psychiatry 83:86–91. https://doi.org/10.1016/j.pnpbp.2018.01.003
Fourrier C, Sampson E, Mills NT, Baune BT (2018) Anti-inflammatory treatment of depression: study protocol for a randomised controlled trial of vortioxetine augmented with celecoxib or placebo. Trials 19:447. https://doi.org/10.1186/s13063-018-2829-7
Kolb H, Mandrup-Poulsen T (2010) The global diabetes epidemic as a consequence of lifestyle-induced low-grade inflammation. Diabetologia 53:10–20. https://doi.org/10.1007/s00125-009-1573-7
Wray NR, Ripke S, Mattheisen M, Trzaskowski M, Byrne EM, Abdellaoui A, Adams MJ, Agerbo E, Air TM, Andlauer TMF, Bacanu SA, Bækvad-Hansen M, Beekman AFT, Bigdeli TB, Binder EB, Blackwood DRH, Bryois J, Buttenschøn HN, Bybjerg-Grauholm J, Cai N, Castelao E, Christensen JH, Clarke TK, Coleman JIR, Colodro-Conde L, Couvy-Duchesne B, Craddock N, Crawford GE, Crowley CA, Dashti HS, Davies G, Deary IJ, Degenhardt F, Derks EM, Direk N, Dolan CV, Dunn EC, Eley TC, Eriksson N, Escott-Price V, Kiadeh FHF, Finucane HK, Forstner AJ, Frank J, Gaspar HA, Gill M, Giusti-Rodríguez P, Goes FS, Gordon SD, Grove J, Hall LS, Hannon E, Hansen CS, Hansen TF, Herms S, Hickie IB, Hoffmann P, Homuth G, Horn C, Hottenga JJ, Hougaard DM, Hu M, Hyde CL, Ising M, Jansen R, Jin F, Jorgenson E, Knowles JA, Kohane IS, Kraft J, Kretzschmar WW, Krogh J, Kutalik Z, Lane JM, Li Y, Li Y, Lind PA, Liu X, Lu L, MacIntyre DJ, MacKinnon DF, Maier RM, Maier W, Marchini J, Mbarek H, McGrath P, McGuffin P, Medland SE, Mehta D, Middeldorp CM, Mihailov E, Milaneschi Y, Milani L, Mill J, Mondimore FM, Montgomery GW, Mostafavi S, Mullins N, Nauck M, Ng B, Nivard MG, Nyholt DR, O’Reilly PF, Oskarsson H, Owen MJ, Painter JN, Pedersen CB, Pedersen MG, Peterson RE, Pettersson E, Peyrot WJ, Pistis G, Posthuma D, Purcell SM, Quiroz JA, Qvist P, Rice JP, Riley BP, Rivera M, Saeed Mirza S, Saxena R, Schoevers R, Schulte EC, Shen L, Shi J, Shyn SI, Sigurdsson E, Sinnamon GBC, Smit JH, Smith DJ, Stefansson H, Steinberg S, Stockmeier CA, Streit F, Strohmaier J, Tansey KE, Teismann H, Teumer A, Thompson W, Thomson PA, Thorgeirsson TE, Tian C, Traylor M, Treutlein J, Trubetskoy V, Uitterlinden AG, Umbricht D, Van der Auwera S, van Hemert AM, Viktorin A, Visscher PM, Wang Y, Webb BT, Weinsheimer SM, Wellmann J, Willemsen G, Witt SH, Wu Y, Xi HS, Yang J, Zhang F, eQTLGen; 23andMe, Arolt V, Baune BT, Berger K, Boomsma DI, Cichon S, Dannlowski U, de Geus ECJ, DePaulo JR, Domenici E, Domschke K, Esko T, Grabe HJ, Hamilton SP, Hayward C, Heath AC, Hinds DA, Kendler KS, Kloiber S, Lewis G, Li QS, Lucae S, Madden PFA, Magnusson PK, Martin NG, McIntosh AM, Metspalu A, Mors O, Mortensen PB, Müller-Myhsok B, Nordentoft M, Nöthen MM, O'Donovan MC, Paciga SA, Pedersen NL, Penninx BWJH, Perlis RH, Porteous DJ, Potash JB, Preisig M, Rietschel M, Schaefer C, Schulze TG, Smoller JW, Stefansson K, Tiemeier H, Uher R, Völzke H, Weissman MM, Werge T, Winslow AR, Lewis CM, Levinson DF, Breen G, Børglum AD, Sullivan PF; Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (2018) Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression. Nat Genet 50:668–681. https://doi.org/10.1038/s41588-018-0090-3
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The German Diabetes Center is funded by the German Federal Ministry of Health (BMG) and the Ministry of Science and Culture of the State North Rhine-Westphalia. This study was also supported in part by a grant from the German Federal Ministry of Education and Research (BMBF) to the German Center for Diabetes Research (DZD e.V.). The funders had no role in study design, data collection, data analysis, data interpretation, writing of the report and decision to publish the manuscript.
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This article is a contribution to the special issue on Inflammation and Type 2 Diabetes - Guest Editor: Marc Y. Donath
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Herder, C., Hermanns, N. Subclinical inflammation and depressive symptoms in patients with type 1 and type 2 diabetes. Semin Immunopathol 41, 477–489 (2019). https://doi.org/10.1007/s00281-019-00730-x
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DOI: https://doi.org/10.1007/s00281-019-00730-x