Erratum to: Diabetologia (2005) 48:294–300 DOI 10.1007/s00125-004-1626-x

Unfortunately there were miscalculations in Tables 3 and 4 of this paper. The corrected tables are reproduced below (with the amended values in colour), along with the corrected paragraph from the Results. The authors believe that these miscalculations are minimal and do not change the conclusion of the paper.

Table 3 HLA-DR-DQ haplotype frequency in type 1 diabetic and normal control subjects
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Table 4 Combination of HLA-DR-DQ haplotype in type 1 diabetic and control subjects
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Serological typing of HLA-DR

The allele frequency of HLA-DR4 was 44.7% in fulminant diabetic patients, 29.1% in autoimmune diabetic patients, and 21.8% in healthy control subjects. HLA-DR4 occurred at a significantly greater frequency in fulminant diabetic patients than in healthy controls (p = 2.85E-09, pc = 2.57E-08, [OR 2.90]), but there was no significant difference in the frequency of HLA-DR4 between autoimmune type 1 diabetic patients and healthy controls. The HLA-DR2 allele was observed in only 1.0% of autoimmune type 1 diabetes, but in 10.1% of fulminant diabetic patients, with a significant difference in the frequency of HLA-DR2 between these two groups (p = 0.0000039, pc = 0.000035). HLA-DR2 was less frequent in fulminant diabetes and autoimmune diabetes than in healthy controls (p = 0.0027, pc = 0.024, [OR 0.47] and p = 2.61E-12, pc = 2.35E-11, [OR 0.04], respectively). HLA-DR9 was significantly more frequent in autoimmune type 1 diabetes than in healthy controls (p = 5.39E-12, pc = 4.85E-11, [OR 3.91]), but was not different in fulminant type 1 diabetes compared with controls. The HLA-DR8 allele was less frequent in fulminant and autoimmune type 1 diabetes than in healthy controls (p = 0.000059, pc = 0.00052, [OR 0.25] and p = 0.0024, pc = 0.021, [OR 0.41], respectively). HLA-DR1 and -DR5 were also less frequent in fulminant type 1 diabetes than in healthy controls (p = 0.017, pc > 0.05, [OR 0.34] and p = 0.0082, pc > 0.05, [OR 0.29], respectively), but there were no significant differences between fulminant and autoimmune type 1 diabetes or between autoimmune diabetes and healthy controls. The differences between phenotypic and allele frequencies in HLA-DR3, -DR6, and -DR7 among the three groups were not significant.