Abstract
Myogenic factor 5 (myf-5) is the product of theMYF5 gene, belonging to theMyoD family. This transcription factor participates in the control of myogenesis. We identified 3 new mutations in the promoter region of the gene:A65 C, C580T andC613T. The aim of this study was to evaluate the influence of theA65C transversion on gene expression. The analysis was conducted on 15 Polish Large White gilts. The relative content ofMYF5 mRNA inm. longissimus dorsi did not differ significantly acrossMYF5 genotypes (AA, AC, CC). This result suggests that theA65C transversion may not play an important role in the expression of theMYF5 gene in analysed adult muscle but it abolishes a putative binding site for two transcription factors (CDP and HSF1) and creates such a site for Sp1.
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Urbański, P., Flisikowski, K., Starzyński, R.R. et al. A new SNP in the promoter region of the porcineMYF5 gene has no effect on its transcript level inm. longissimus dorsi . J Appl Genet 47, 59–61 (2006). https://doi.org/10.1007/BF03194600
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DOI: https://doi.org/10.1007/BF03194600