Summary
The results obtained in wake and sleep conditions by PRL determinations performed in 6 normoprolactinemic infertile women with determined by RIA in blood samples collected at 20-min intervals from 1800 to 0800. LPD has been previously demonstrated by endometrial biopsy, basal temperature and circulating progesterone determinations. PRL levels were also determined in 5 normal women used as control subjects under the same experimental conditions. The results obtained, expressed as means±SD of LPDvs. control group, were 15.9±4.6vs. 11.6±3.3 ng/ml (p>0.1) in wake conditions and 31.9±5.9vs. 21.4±5.7 ng/ml (p<0.01) in sleep conditions. PRL values during the highest pulse (HP) in sleep and wake conditions were 20.9±5.2vs. 17.0±3.3 ng/ml (p<0.1) and 51.1±17.1vs. 34.3±2.4 ng/ml (p<0.01), respectively. In 2 out of the 6 patients mean PRL values were 22.0 and 26.5 ng/ml during sleep, and 26.0 and 33.0 ng/ml during HP. These values were not statistically significant when compared with those obtained in the control group. The results obtained show that 4 out of the 6 patients with LPD and normal PRL levels in wake conditions had sleep-dependent hyperprolactinemia due to the pulses with a more significant amplitude. These findings suggest that in some cases sleep-induced hyperprolactinemia might be involved in LPD pathogenesis.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Andersen A. N., Larsen J. F., Eskildsen P. C., Knoth M., Micic S., Sugnstrup B., Nielsen J.: Treatment of hyperprolactinemic luteal insufficiency with bromocryptine — Acta obstetr. gynecol. scand.58, 379, 1979.
Board J. A., Storlazzi E., Schneider V.: Nocturnal prolactin levels in infertility — Fertil. and Steril.34, 720, 1980.
Bohnet H. G., Dahlen H. G., Wuttke W., Schneider H. P. G.: Hyperprolactinemic anovulatory syndrome — J. clin. Endocrinol.42, 132, 1975.
Del Poao E., Wyss H., Tolis G., Alañiz P., Campana A., Naftolin F.: Prolactin and deficient luteal function — Obstetr. and Gynecol.53, 282, 1979.
Desir D., Van Cauter E., L’Hermite M., Refetoff S., Jadot C., Caufriez A., Copinschi G., Robyn G.: Effects of ‘jet-lag’ on hormonal patterns. III. — J. clin. Endocrinol.55, 849, 1982.
El Mahgoubs C.: Galactorrhea and the defective luteal phase of the menstrual cycle — Int. J. Gynaecol. Obstetr.16, 124, 1978.
Muhlenstedt D., Bohnet H. G., Hanker J. P., Schneider H. P. G.: Short luteal phase and prolactin — Int. J. Fertil.23, 213, 1978.
Sassin J. F., Frantz A. G., Weitzman E. D., Icapen S.: Human prolactin: 24-hour pattern with increased release during sleep — Science177, 1205, 1972.
Scaglia H. E., Colombani M., Zylbersztein C., Margulies M., Alvarez S., Voto L. S.: Prolactin, estriol and progesterone levels in frequent blood samples throughout normal pregnancy — La Ricerca Clin. Lab.11, 65, 1981.
Scaglia H. E., Margulies M., Galimberti D., Colombani M., Spinedi E., Zylbersztein C., Aquilano D.: Binding of prolactin by fetal human lung cell membrane fractions — La Ricerca Clin. Lab.11, 279, 1981.
Seegar Jones G.: The luteal phase defect. In:Nallachand R. D., Kempers R. D. (Eds): Modern trends in infertility and conception control. Williams and Wilkins Co., Baltimore, 1979; p. 151.
Tambascia M., Bahamondes L., Pinoti J., Motta Collier A., Dachs J. N., Faundes A.: Sustained hyperprolactinemia in a normally menstruating woman with apparently normal ovarian function — Fertil. and Steril.34, 282, 1980.
Tolis G., Naftolin F.: Induction of menstruation with bromocryptine in patients with euprolactinaemic amenorrhoea — Amer. J. Obstetr. Gynecol.126, 426, 1976.
Van Cauter E., Desir D., Refetoff S., Spire J. P., Noel P., L’Hermite M., Robyn C., Copinschi G.: The relationship between episodic variations of plasma prolactin and REM-non-REM cyclicity is an artifact — J. clin Endocrinol.54, 70, 1982.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Scaglia, H.E., Drón, N., Ramos, G. et al. Sleep-dependent hyperprolactinemia andCorpus luteum pathogenesis. La Ricerca Clin. Lab. 15, 159–165 (1985). https://doi.org/10.1007/BF03029834
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF03029834