Summary and Conclusions
The effect of intravenous trimethobenzamide, trimeprazine, diphenhydramine, dimenhydrinate, and cyclizine on salivary secretion was studied in eight healthy male adult subjects. A mixture of carbaminoylcholine chloride was used to stimulate secretions. The dose selected for each drug was that used for an optimum therapeutic activity of its most desirable effect.
Cyclizine was the most effective antisialogogue of this group, and it also caused moderate drowsiness. Trimeprazine, diphenhydramine, and dimenhydrinate exceeded 50 per cent effectiveness as antisialogogues, and caused varying degrees of drowsiness.
Trimethobenzamide was not effective as an antisialogogue, and did not cause any other objective effects.
Résumé
Nous avons pratiqué, en duplicata, des tests en série sur huit adultes mâles en santé avec un mélange de chlorure de carbaminoylcholine et ďadrénaline (comme contrôle) puis avec de la trimethobenzamide, de la triméprazine, de la diphenhydramine, du dimenhydrinate et de la cyclizine pour évaluer leur pouvoir antisialagogue. Au cours du test de contrôle, la salive était prélevée du canal de la parotide durant 10 minutes avant ľadministration de tout médicament et, ensuite, durant 30 minutes après ľinjection du mélange.1 Au cours des autres tests, les médicaments étaient administrés par voie intraveineuse au début de ľexpérience et la salive était ramassée durant 10 minutes. Alors, nous injections le mélange et, de nouveau, nous prélevions la salive durant 30 minutes. Nous avons employé, chez tous les sujets, la même glande parotide que nous avions choisie au début au cours de tous les tests et nous avons tenu compte des volumes à toutes les 10 minutes.
La cyclizine, parmi les médicaments mentionnés ci-haut, s’est avérée le plus efficace antisialagogué et elle a aussi causé des vertiges. La triméthobenzamide a peu ou pas de pouvoir antisialagogue. La trimeprazine, la diphenhydramine et le dimenhydrinate ont dépassé un pouvoir de 50% comme antilialogogues et ils ont causé divers degrés de vertiges.
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From the Department of Anaesthesia, University Hospital, University of Saskatchewan, Saskatoon, Sask.
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Dobkin, A.B., Criswick, V.G. The antisialogogue effect of trimethobenzamide hcl (Tigan®), trimeprazine tartrate (Panectyl®), diphenhy-dramine hcl (Benadryl®), dimenhydrinate (Gravol®, Dramamine®), and cyclizine lactate (Marzine®, Marazine®). Can. Anaes. Soc. J. 8, 154–158 (1961). https://doi.org/10.1007/BF03021344
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DOI: https://doi.org/10.1007/BF03021344