Abstract
Cardiac surgery with hypothermic cardiopulmonary bypass (CPB) is among the most commonly performed operations in Canada today. The potential effects of hypothermia and CPB on the disposition of certain opioids are reviewed. Reasons for prolongation of the elimination half-time of the opioids used during cardiac surgery are explored. The roles that age, hypothermia, protein binding and drug sequestration may play in changing opioid pharmacokinetic behaviour are examined and suggestions for future research are made.
Résumé
La chirurgie cardiaque avec CEC hypothermique est parmi l’une des opérations les plus fréquentes de nos jours au Canada. Les effets potentiels de l’hypothermie et la CEC sur la disposition de certains opiacés sont revus. Les raisons de la prolongation du demitemps d’élimination des opiacés utilisés lors de la chirurgie cardiaque sont explorées. Le rôle de l’âge, l’hypothermie, la lésion protéique et la séquestration des médicaments dans l’altération de la pharmacocinétique des opiacés sont examinés et des suggestions pour des recherches futures sont suggérées.
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Hall, R. The pharmacokinetic behaviour of opioids administered during cardiac surgery. Can J Anaesth 38, 747–756 (1991). https://doi.org/10.1007/BF03008453
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DOI: https://doi.org/10.1007/BF03008453