Abstract
To assess the impact of surgical stimulation on regulation of ventilation in anaesthetized man, we measured ventilation and the ventilatory responses to either hyperoxic hypercapnia or to isocapnic hypoxaemia in fifteen subjects anaesthetized with enflurane 1.1 MAC, just prior to and then during a surgical procedure. Anaesthesia alone reduced ventilation, increased Paco2 decreased the response to carbon dioxide and virtually abolished the response to hypoxaemia. The addition of operation at the same level of anaesthesia augmented ventilation and reduced Paco2 but did not improve the anaesthesia-induced impairment of the responses to hypercarbia and hypoxaemia. Over the range of PCO2 and PO2, values studied, the effects of surgery were constant and independent of chemical drive. A.M. Lam, M.D., Resident; J.L. Clement, R.N.; R.L. Knill, M.D., F.R.C.P.(C), Associate Professor; Department of Anaesthesia, University Hospital, University of Western Ontario, London, Canada. This work was supported by the Medical Research Council of Canada, Development Grant 150. Address reprint requests to Dr. R.L. Knill, Department of Anaesthesia, University Hospital, 339 Windermere Road, London, Ontario, Canada, N6A 5A5.
Résumé
Dans le but ďévaluer ľinfluence de la stimulation chirurgicale sur le contrôle de la ventilation de ľhumain sousanesthésie, on a mesuré la ventilation et la réponse ventilatoire à ľhypercapnie en hyperoxie et à ľhypoxémie en isocapnie chez 15 sujets anesthésiés à ľenflurane (1.1 MAC). Les mesures ont été effectuées juste avant la stimulation chirurgicale ainsi que durant la chirurgie. Ľanesthésie sans stimulation chirurgicale réduisait la ventilation avec élévation de la Paco2 diminuait la réponse au CO2 et abolissait virtuellement celle à ľhypoxémie. La chirurgie au mème niveau ďanesthésie s’accompagnait ďune augmentation de la ventilation avec diminution de la Paco2 mais ne modifiait pas les réponses ventilatoires à ľhypoxémie et à ľhypercarbie produites par ľanesthésie. Ľinfluence de la chirurgie était constante aux valeurs de Pco2 et de Po2 étudiées.
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An erratum to this article is available at http://dx.doi.org/10.1007/BF03007444.
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Lam, A.M., Clement, J.L. & Knill, R.L. Surgical stimulation does not enhance ventilatory chemoreflexes during enflurane anaesthesia in man. Canad. Anaesth. Soc. J. 27, 22–28 (1980). https://doi.org/10.1007/BF03006843
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DOI: https://doi.org/10.1007/BF03006843