Conclusion
By repeated testings the Frei test has proven specific and has assisted in the recognition of the heretofore unaccepted therapy of L.V. Over a period of two years we have observed these patients and their Frei reactions in various stages of the disease, and feel that in the presence of clinical evidence one negative test should not be considered as confirmatory that the process is not one of L.V. To a large degree, incorrect readings may be obviated by careful selection of the tissue used, strict adherence to the preparation and preservation of the antigen, its method of administration and time of reading.
We consider the Frei test to be of utmost value in the diagnosis of L.V. judging from our total series of 155 cases bearing a positive percentage of 96.7 that clinically and pathologically presented manifestations of this disease, but we do concur with Guy del Vivo (44) that further and more conclusive evidence should be sought as to its etiology.
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References
Alley, R.: Lymphopathia Venerea.Trans. Amer. Proc. Soc., p. 150, 1934.
Alley, R.: Lymphopathia Venerea Involving the Rectum.Kentucky M. J., p. 250, Bowling Green, Vol. XXVI, 1934.
Almkvist, J.: En praktisk behandlingsmetod for ulcus molle.Allm, Sv. Lakretidn, No. 23, 1906.
Amtman, L., and Pilot, L.: Lymphogranuloma Inguinale, three cases from Chicago.Arch. Derm. and Syph., Vol. XXVI, p. 868, 1932.
Amwyl, Davies T.: Lymphogranuloma Inguinale.Lancet, Vol. II, p. 289, 1933.
Aronson, J. D.: Purified Protein Derivative.Supp. Amer. Rev. Tuberc., p. 727, Vol. XXXVI, No. 2, Dec., 1934.
Bacon, H. E.: Lymphogranuloma Inguinale, Disc.Urol, Sect. Penn. State Med., Wilkes-Barre, Oct., 1934.
Bacon, H. E.: Lymphopathia Venerea, Frei test Statistics, Staff Meeting Grad. Hosp., Univ. of Pennsylvania, Feb., 1934.
Bacon, H. E.: Stricture of the Rectum.Cyclo. Med., Vol. X, p. 1116, F. A. Davis & Co., Philadelphia, 1934.
Bacon, H. E.: The ubiquity of Lymphogranulomatosis Venerea. Read before the Proc. Soc., Allentown, April 24, 1934.
Barthels, C., and Biberstein, H.: Zur Ethiologie der entzundlichen Rektumstrikturen, Burns.Beitr., Zur. Klin., Chir., Vol. CLII, p. 161, 1930.
Bensaude: Quoted by Frei.
Bensaude, R.: Les retrecissements du rectum.Bull. Med., Vol. XVIII, p. 421, 1932.
Bensaude, R., and Lambling, A.: The role of Nicolas-Favre’s Disease in the Etiology of Inflammatory Stricture of the Rectum. Study in 21 cases with the Aid of Frei’s intradermal reaction.Comp. rend. des seances de la Soc. de Bibliog., 108, p. 1050, 1931.
Bianchi, T. B., and Coutts, W. E.:Arch. Derm. and Syph., Vol. 28, p. 32, July, 1933.
Biberstein, H. Oschinski: Versuche uber die Empfindlichkeit der Menschlichen Haut gegen Tiersera.Arch and Dermat. u. Syph., 142, 1931.
Bloom, D.: Strictures of the Rectum due to Lymphogranuloma Inguinale.S. G. O., Vol. LVIII, No. 5, p. 827, May, 1934.
Burney, L. E.: Lymphogranuloma Inguinale.Ven. Dis. Bull., 15, p. 233, July, 1934.
Cedercreutz, A.: Lymphogranulomatosis inguinalis.Finska. Lak. Sallak. Handl., Vol. LXX, p. 1036, 1928.
Cole, H. N.: Lymphogranuloma inguinal, Fourth, Venereal Disease; Its Relation to Stricture of the Rectum.J. A. M. A., Vol. 101, p. 1068, Sept. 30, 1933.
Cole, H. N.: Personal Communication, May 8, 1935.
Corachan, M.: Inflammatory Rectal Stenosis. Arch. de med.,Cir.y, espec., 35; 429, Madrid, May, 1932.
Cormia, F. E.: Lymphogranulomatosis Inguinale, A Review of the Literature.Urol and Cutan. Rev., p. 789, Nov., 1934.
Coutts, W. E.: Genito-Ano-Rectal Lymphogranulomatosis of the Male.Ann. Surg., Vol. XCIX, No. 1, p. 188, Jan., 1934.
Coutts, W. E., and Ponce, T.: The Complement Fixation in the Diagnosis of Lymphogranulomatosis Venerea.Jour. Lab. and Clin. Med., Vol. XX, No. 6, p. 629, March, 1935.
Coutts, W. E., and Bianchi, T. B.: Lymphogranulomatosis Venerea and Its Clinical Syndromes.Urol and Cutan., Rev., p. 263, April, 1934.
Coutts, W. E.; Herrea, J., and Martini and Perroni, F.: Lymphogranulomatosis Venerea.Amer. Jour. Surg., 22, 96, Oct., 1933.
Curth, W.: Personal Communication, May 8, 1935.
Dalton, J. E.: Lymphogranulomatosis Inguinalis.Jour. Indiana State Med., p. 158, Vol. 27, No. 14, April, 1934.
Dalton, J. E.: Personal Communication.
de Gregorio, E.: Elefantiasis y ulceraciones cronicas vulvares.Act. Derm. Sifil., Madrid, 1931.
deMonbreum, W. A., and Goodpasture, E. W.: Further Studies on the Etiology of Granuloma Inguinale.Amer. Jour. Trop. Med., Vol. XIII, p. 447, 1933.
DeWolf, H. F., and Van Cleve, J. V.: Lymphogranuloma Inguinale,J. A. M. A., No. 13, Vol. 99, p. 1066, Sept. 24, 1932.
DeWolf, H. F.: Personal Communication, May 13, 1935.
Dind: Quoted by Hellerstrom.
Felchenfeld, H.: Etiology of Elephantiasis Vulvae Anorectitis Associated with Rectal Strictures, with Special Reference to Lymphogranulomatosis Inguinale.Med. Wchnschr., 28, 965, July, 1932.
Fischer, A. W., and Schmidt La Baume: Rectal Strictures and Lymphogranuloma Inguinale.Deut. med. Wchnshr., B. 58, S. 572, April, 1932.
Fischer, O.: Uber eine Hautreaktion bei Klimalischen Bubones.Klin. Woch., p. 6, 1926.
Frei, W.: Lymphogranulomatosis Inguinalis.Klin. Woch., B. 23, 1927.
Frei, W.: Lymphogranulomatosis Inguinalis, Die Haut, Geschlichlskrankheiten, Londerdruck au Band, V. Urban and Schwarzenberg, Berlin, 1934.
Frei, W.: Der Gagenwartige stand der Kenntnisse von der Elephantiasis genito anorectalis.Deut. Med. Wchnschr., Nr. 50, S. 1964, 1932.
Frei, W.: Eine neue Hartreaktion bei Lymphogranuloma inguinale.Klin. Wchnschr., B. IV, p. 2148, Nov., 1925.
Fuhs, H.: Lymphadenitis inguinalis chronica.Unklerer, Aetiologie, Wiener, Dermat., XI, 17, 1927.
G. del. Vivo:Gior ital di dermat. e sif., Vol. 74, p. 735, June, 1933.
Geisler, H.: The Diagnosis of Lymphogranuloma Inguinale.Klin. Wochen., S. 11, 1928.
Grace, A. W.: Personal Communication, May, 1935.
Gray, J., and Yieh, J. C.: Lymphogranuloma Inguirale among Chinese.Chinese Med. Jour., Vol. 48, No. 7, p. 607, July, 1934.
Grossman, S. L.: Lymphogranuloma Inguinale.Urol. Sect. Penns. State Med. Soc., Wilkes-Barre, Oct., 1934.
Hall, C.: The Value of the Tuberculin Test.Jour. Kansas Med. Soc., Vol. XXXVI, No. 2, Feb., 1935.
Hayden, E. P.: Personal Communication, May 6, 1935.
Hayes, H. T., and Burr, H.: Personal Communication, May, 1935.
Hellerstrom, S.: Contribution a l’etude de la Lymphogranuloma Inguinale, Extract des Annales des Maladies Venerienees, p. 10.Grande Imprimeria de Troyes, 1929.
Hellerstrom, S.: Contribution to the Knowledge of Lymphogranuloma Inguinale, p. 117.Acte. Dermato-Venerologica, Kungl. Boktrycheriet, Stockholm, 1929.
Hellerstrom, S.: Epidemiology and Etiology and Lymphogranuloma Inguinale, Lennander Lecture, p. 14, Massen et Cie, 1934.
Hellerstrom, S.: Experience avec l’intradermo-reaction dans la maladie de Nicolas-Favre, Bull de la Soc. France, Dermat. and Syphil., Masson & Cit, Paris, No. 4, April, 1931.
Hellerstrom, S.: Zur Kenntnis Der Hautallergie Bei Lymphogranuloma Inguinale.Klin Wchnschr., Nr. 13, S. 595, J. 10, Marz. 28, 1931.
Hermans, E.: Climate Buboes and Inguinal Lymphogranuloma.Klin. Wchnschr., 7, 2436, 1928.
Hill, M. R.: The Frei Antigen Reaction in Benign Rectal Strictures.Trans. Amer. Proc. Soc., p. 163, 1934.
Hillsman, J. A.: Wilshusen, H. F., and Zimmerman, H. M.: Lymphopathia Venereum and the Frei test.Brit. Jour. Derm. and Syphil., Vol. XLIV, p. 192, 1932.
Howard, M. E., and Strauss, M. J.: Lymphogranuloma Inguinale Report of 16 cases in and around New Haven.
Jersilk, O.: Intradermal Reaction in Ulcus Molle and Lymphogranuloma Inguinal.Ann. Derm. et Syph. 11, p. 577, 1930.
Kitchevatz, M.: A Specific Allergic Reaction in Nicholas-Favre Disease.Soc. Derm. et Physiol., p. 35, 1928.
Koch, F.:Dermat Ztschr., B. 65, Jan., 1933.
Koppel, A.: Lymphogranuloma Inguinale with Rheumatic Symptomatology.Klin. Wochen., 52, 1927.
Langer, E., and Engle, C.: Zur Frage der Lymphogranuloma Inguinale Recti.Munch. med. Wchnschr., Vol. IX, p. 350, 1932.
Leadrich, L.: Levaditi, C.; Mamon, H., and Beauchesne, H.: Inflammatory Stricture of the Rectum, Atypical Aberrant form of Nicolas-Favre’s Disease, Inoculation of Apes Positive.Bull. Men. Soc. Hospit., 48, p. 1072, July 4, 1932.
Lee, H., and Staley, R. W.: Inflammatory Stricture of the Rectum and Their Relation to Lymphogranuloma Inguinale.Ann. Surg., Vol. C, p. 486, Sept., 1934.
Lehman, C. F., and Pipkin, J. L.: Lymphopathia Venerea.Texas State Med. Jour., 29, 192, July, 1933.
Lehman, C. F., and Pipkin, J. L.: Personal Communication, May 10, 1935.
Lepinay, G.: The Frei Reaction.Bull. Soc. Franc. Dermat. et Syph., 40, 782, May, 1933.
Loehe, H., and Rosenfeld, H.: Neue Ergebnisse über die Spael formen des Lymphogranuloma Inguinale.Med. Klin., B. XXXIII, S. 1486, 1932.
Long, E. R.; Aronson, J. D., and Seibert, F. B.: Tuberculin Surveys with the Purified Protein Derivative.Supp. Amer. Rev. Tuberc., p. 733, Vol. XXXVI, No. 6, Dec., 1934.
Lutz, K.: Entzuendliche Reklimstrikturen durch Lymphogranuloma Inguinale.Deut. Med. Wchnschr., B. LVIII, 1360.
Marino, M.: Personal Communication, May 3, 1935.
Martin, C. F.: Lymphopathia Venerea, Disc., p. 173.Trans. Proc. Soc., 1934.
Martin, C. F.: Stricture of the Rectum.J. A. M. A., Vol. 101, No. 20, p. 1550, Nov. 11, 1933.
Martin, C. F.: Lymphopathia, Venerea.Forum Aes. C., Nov., 1933.
Martin, C. F., and Bacon, H. E.: Symposium on Lymphopathia Venerea. Staff Meeting Grad. Hosp., Univ. of Pennsylvania, Feb., 1935.
Meyer, K., and Rosenfeld, H.: Erfolgreich Ueberttragung des Lymphogranuloma Inguinale auf Meerschweinchen.Klin. Wchr., Vol. 10, p. 1653, Sept., 1931.
Mytinger, W. H.: The Tuberculin Test.Jour. Indiana State Med., Vol. XXVII, No. 12, p. 579, Dec., 1934.
Nicholas, J.; Favre, M.; Lebeuf, F., and Charpy, J.: Intradermo-reactions positives dans la maladie de Nicolas-Favre avec une antigens tire d’une forme anorectale elephantiasique de la maladie.Bull. Soc. franc. de dermat. et Syph., Vol. XXXIX, p. 24, 1932.
Nicholas, J.; Favre, M., and Massia, G.: Retrecissement Anorectal Elephantiasique et Lymphogranulomatose Inguinale.J. A. M. A., Lyon, Vol. CCLXXIIII, p. 303, 1931.
G. Prieto: Quoted by Frei.
Prieto, J. G.: The Biological Treatment of Subacute Lymphogranulomatosis with Intravenous Injections of Specific Antigen.Arch. d. med. Cerug. y. espanol., 13 and 85, 1932.
Ramel, E.: Betrage zur Kenntnis der Lymphogranulomatosis Inguinales.Derm. Zeit., Vol. LIII, 1928.
Ravaut, P.; Levaditi, C.; Lambling, A., and Cachera, R.: La presence du virus de la maladie de Nicholas-Favre dans les lesions d’une malade attent d’anorectite ulcero-vegetante.Bull. acad. de med., Vol. XCVIII, 98, 1932.
Reenstierna, J.: Recherches Sur Le Bacille de Ducrey Extrait des arch d l’ instit. Pasteur de Tunis, Tome XII, fasc. 3, p. 273, 1923.
Reenstierna, J.: En Mer An 1 — Arig Ulcus Molle-Infektion.Lakt. Efter Serumbehandlin Lartruck Ur Hygiea, 1920.
Reenstierna, J.: Chancre mou experimental chez le singe et le lapin, acta Dermato-Venerea, Vol. II, Fasc. Mars., 1931.
Seibert, F. B.: Trans. Ann. meeting, Nat’l Tuberc. Assn., p. 165, 1933.
Seibert, F. B.: Isolation and Properties of the Purified Protein Derivative of Tuberculin.Supp. Amer. Rev. Tuberc., p. 713, Vol. XXX, No. 6, Dec., 1934.
Seneque, J.: Maladie de Nicolas et Favre et retrecissment du Rectum.Presse Med., Vol. II, p. 22, 1932.
Strauss, H.: Zur Frage d Atiologie de Venerischen Rektalstrekturen.Dermat. Woch., B. 96, p. 235, 1933.
Strauss, M. J., and Howard, M. E.: The Frei test for Lymphogranuloma Inguinale.J. A. M. A., Vol. 103, No. 24, p. 1830, Dec. 15, 1934.
Stillman, A.: Stricture of the Rectum.Ann. Surg., Vol. 101, No. 5, p. 1284.
Stillman, A.: Personal Communication, May 9, 1935.
Streicher, M. H.: Rectal Obstruction.Ill. Med. Jour., 64, p. 133, Aug., 1933.
Sulzberger, M. B. et al: Personal Communication.
Sulzberger, M. B., and Wise, F.: Lymphopathia Venereum.J. A. M. A., No. 17, Vol. IC, p. 1407, Oct. 22, 1932.
Templeton, H. J., and Smith, D.: Lymphogranuloma Inguinale.California and Western Med., 41, p. 42, July, 1934.
Van Cleve, J. C.: Personal Communication, May 1, 1935.
Vander Veer, J. B.: Personal Communication, April 14, 1935.
Vizcarronde, E.: La reaction de Frei cu las adenopatias inguinales y en las estre chices reactales.Gas. Med. de caracas, 23, 1932.
Von Veress, F.: Lymphogranulomatosis Inguinalis.Derm. Wchnschr., 96, 201, Feb., 1933.
Wang, L. K., and Shen, J. K.: Lymphogranuloma Inguinale, Report of Five Cases.Chinese Med. Jour., Vol. 48, No. 7, p. 615, July, 1934.
Wassen, E.: Transmission of Inguinal Lymphogranulomatosis to Guinea pigs.Compt. rend. Soc. de Biol., Vol. CXVI, p. 121, Paris, 1934.
Wien, M. S., and Perlstein, M. O.: Intradermal Treatment of Lymphogranuloma Inguinale Prelim, Report.Arch. Dermat. and Syphil., Vol. XXVIII, p. 42, July, 1933.
Wolf, J., and Sulzberger, M. B.: Llymphopathia Venereum and the Frei test.Brit. Jour. Dermat. and Syphil., 44, 192, April, 1932.
Yu Tun Pe: The Value of Specific Ducrey Bacillus, Vaccine in the Diagnosis and Treatment of Inguinal Bubo.Dermat. Wchnschr., 99, 1642, Leipzig, Dec. 22, 1934.
Zakon, S. J.: Lymphogranuloma Inguinale or Durand Nicholas-Favre Disease.Arch. Dermat. and Syphil., 26, p. 238, Aug., 1932.
Burney, L. E.: Personal Communication, May 8, 1935.
Martin, C. F., and Bacon, H. E.: Lymphopathia Venerea. Accepted for publication May 5, 1935, International Clinics.
Stillman, A.: Stricture of the Rectum.Ann. Surg., Vol. 101, No. 5, p. 1284, May, 1935.
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From the Departments of Proctology, Graduate Hospital, University of Pennsylvania, Temple University and St. Luke’s Hospitals.
Read at the thirty-sixth annual meeting of the American Proctologic Society, Atlantic City, June 10th and 11th, 1935.
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Bacon, H.E. The specificity of the Frei test in lymphopathia venera. American Journal of Digestive Diseases and Nutrition 2, 570–574 (1935). https://doi.org/10.1007/BF03000929
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DOI: https://doi.org/10.1007/BF03000929