Summary
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1.
Loops of intestines of 48 dogs were exposed to 0.1 per cent pepsin in N/10 HCl under various hyrostatic pressures.
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A rise in intraintestinal pressure resulted in a marked increase in the extent of peptic digestion which led to perforation in a short time. At 45 cm. pressure the average time for perforation was 300 minutes; at 90 cm. pressure, 82 minutes; and at 135 cm. pressure only 41 minutes.
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Driver, R.L., Chappell, R.H. & Carmichael, E.B. Effect of hydrostatic pressure on the experimental production of ulcers. Jour. D. D. 12, 168–169 (1945). https://doi.org/10.1007/BF02998662
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DOI: https://doi.org/10.1007/BF02998662