Summary
In order to get the best assurance that two mutation frequencies differ, or the best estimate of their ratio, the number of gametes tested in a series of experiments should be inversely as the square root of the expected mutation frequency. In order to get the best estimate of the difference of two mutation rates it should be directly as the square root of this frequency.
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References
Auerbach, C. (1962).Mutation. An Introduction to Research on Mutagenesis. Part I. Methods. Oliver and Boyd, Edinburgh.
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Haldane, J.B.S. The design of experiments on mutation rates. J Genet 58, 232–236 (1963). https://doi.org/10.1007/BF02986142
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DOI: https://doi.org/10.1007/BF02986142