Abstract
Tryptophan promoter is widely used in the industrial fermentation for the overproduction of recombinant proteins. It can be regulated by the concentrations of tryptophan and 3β-indolea-crylic acid (IAA). A mathematical model is proposed for the regulation of the promoter by the manipulation of tryptophan and IAA concentrations. The transcription initiation frequency increases with IAA concentration and reaches a plateau. The frequency decreases drastically even with the addition of a small amount of tryptophan. These behaviors agree with the previous experimental investigation.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Rosenberg, M. and Court, D.:Ann. Rev. Genet.,13, 319 (1979).
Emtage, J. S., Tacon, W. C. A., Catlin, G. H., Jenkins, B., Porter, A. G. and Carey, N. H.:Nature,283, 171(1980).
Leung, D.W., Capon, D.J. and Goeddel, D.V.:Bio/Technol.,2, 458 (1984).
Rosenberg, S. A., Grimm, E. A., McGrogan, M., Doyle, M., Kawasaki, E., Koths, K. and Mark, D. F.:Science,223, 1412(1984).
Park, T. H., Seo, J.-H. and Lim, H. C.:Biotechnol. Bioeng.,34, 1167(1989).
Yoon, S. K., Kang, W. K. and Park, T. H.:Biotechnol. Bioeng.,43, 995(1994).
Kawai, S., Mizutani, S., Iijima, S. and Kobayashi, T.:J. Ferment. Technol.,64, 503(1986).
Baker, R. F. and Yanofsky, C: Proc. Natl. Acad. Sci. U. S. A.,60, 313 (1968).
Imamoto, F.: Proc. Natl. Acad. Sci. U. S. A.,60, 305 (1968).
Morse, D.E., Mosteller, R. D. and Yanofsky, C: Cold Spring Harbor Symp. Quant. Biol.,34, 725 (1969).
Baker, R. and Yanofsky, C: Cold Spring Harbor Symp. Quant. Biol.,35, 467(1970).
Baker, R. and Yanofsky, C:J. Mol. Biol.,69, 89 (1972).
Bertrand, K., Squires, C. and Yanofsky, C.:J. Mol. Biol.,103, 319(1976).
Jackson, E. N. and Yanofsky, C:J. Mol. Biol.,69, 307 (1972).
Yanofsky, C, Kelley, R. L. and Horn, V.:J. Bacteriol.,158, 1018(1984).
Park, T. H., Seo, J.-H. and Lim, H. C.:Biotechnol. Lett.,11, 87(1989).
Shinha, S.:Biotechnol. Bioeng.,31, 117(1988).
Koh, B. T. and Yap, M. G. S.:Biotechnol. Bioeng.,41, 707 (1993).
Joachimiak, A. R., Kelley, L., Gunsalus, R. P., Yanofsky, C. and Sigler, P.: Proc. Natl. Acad. Sci. U. S. A.,80, 668(1983).
Joachmimiak, A. R., Schevitz, R. W., Kelley, L., Yanofsky, C. and Sigler, P. J.:Biol. Chem.,258, 12641 (1983).
Schevitz, R. W., Otwinowski, Z., Joachimiak, A., Lawson, C. L. and Sigler, P. B.:Nature (London),317, 786 (1985).
Arvidson, D. N., Bruce, C. and Gunsalus, R. P.:J. Biol. Chem.,261, 238(1986).
Joseph, D. R. and Muench, K. H.:J. Biol. Chem.,246, 7602 (1971).
Joseph, D. R. and Muench, K. H.:J. Biol. Chem.,246, 7610(1971).
Pabst, M.J., Kuhn, J. C. and Somerville, R.L.:J. Biol. Chem.,248, 910(1973).
Zalkin, H.: “Multifunctional Enzymes”, eds. Bisswanger, H. and Schmincke-Ott, E., 1213, John Wiley and Sons, Inc., New York (1980).
Das, A., Drawfold, I. P. and Yanofsky, C:J. Biol. Chem.,257, 8795 (1982).
Haydock, P.V. and Somerville, R. L.:Biochem. Biophys. Res. Commun.,119, 926(1984).
Rose, J. K., Squires, C. L., Yanofsky, C., Yang, H. L. and Zubay, G.:Nature (London) New Biol.,245, 133 (1973).
Zubay, G., Morse, D. E., Schrenk, W. J. and Miller, J. H.: Proc. Natl. Acad. Sci. U. S. A.,69, 1100 (1972).
Squires, C. L., Lee, F. and Yanofsky, C:J. Mol. Biol.,92, 93 (1975).
Kelley, R. L. and Yanofsky, C: Proc. Natl. Acad. Sci. U. S. A.,79, 3120 (1982).
Yanofsky, C. and Crawford, I. P.: in “E. coli and Salmonella typhimurium vol. 2”, eds. Neidthard, F. C, Ingraham, J. L., Low, K. B., Magasanik, B. and Schaechter, M., 1453, American Society for Microbiology, Washington DC (1987).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Park, T.H. A mathematical model for the regulation of tryptophan promoter. Korean J. Chem. Eng. 11, 282–289 (1994). https://doi.org/10.1007/BF02697395
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02697395