Abstract
Linoleate hydroperoxides from autoxidation of methyl linoleate and from lipoxidase oxidation of linoleic acid are compared. Data indicate an equal amount of methyl 9- and 13-hydroperoxyoctadecadienoate produced by autoxidation of methyl linoleate, and the exclusive formation of 13-hydroperoxyoctadeca-9,11-dienoic acid from the incubation of lipoxidase with linoleic acid. As a result of these findings, a specific mechanism for the reaction of lipoxidase with linoleic acid is postulated.
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This work was conducted under a Postdoctoral Resident Research Associateship established at the Northern Laboratory by ARS, USDA, in association with the National Academy of Sciences-National Research Council.
No. Utiliz. Res. Dev. Div., ARS, USDA.
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Dolev, A., Rohwedder, W.K. & Dutton, H.J. Mechanism of lipoxidase reaction. I. Specificity of hydroperoxidation of linoleic acid. Lipids 2, 28–32 (1967). https://doi.org/10.1007/BF02531996
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DOI: https://doi.org/10.1007/BF02531996