Abstract
Cellular growth on intraocular lenses can be observed by using a specular microscope. We examined in vivo the cellular pattern on the surface of implanted lenses during the early postoperative period in 63 patients. In every case inflammatory cells were noted on the lens surface at some point during the observation period. These often showed a spindle-like appearance resembling fibroblasts. The density of the cell population increased during the following days but usually did not exceed 100 cells/mm2. From the end of the first week, multinucleated giant cells may appear. In one case, a patient with a severe postoperative iritis and hypopyon demonstrated an extremely pronounced and long-lasting cellular proliferation.
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Allgöwer M, Hulliger L (1960) Origin of fibroblasts from mononuclear blood cells: a study on in vitro formation of the collagen precursor, hydroxyproline, in buffy coat cultures. Surgery 47: 603–610
Apple DJ, Craythorn JM, Olson RJ, Little LE, Lyman JB, Reidy JJ, Loftfield K (1984) Anterior segment complications and neovascular glaucoma following implantation of a posterior chamber intraocular lens. Ophthalmology 91: 403–419
Bene C, Kranias G (1986) Possible intraocular lens contamination by surgical glove powder. Ophthalmic Surg 17: 290–291
Bourne WM, Kaufman HE (1976) Endothelial damage associated with intraocular lenses. Am J Ophthalmol 81: 482–485
Bryan III JA, Peiffer RL, Brown DT, Eifrig DE, Vallotton WW (1985) Morphology of pseudophakic precipitates on intraocular lenses removed from human patients. J Am Intraocul Implant Soc 11: 260–267
Conheim J (1867) Über Entzündung und Eiterung. Virchow's Arch [A] 40: 1–79
Daicker B (1984) Perilenticular tissue changes caused by intaocular lenses with no history of clinical complications. Klin Monatsbl Augenheilkd 184: 419–422
Drews RC, Smith ME, Okun N (1978) Scanning electron microscopy of intraocular lenses. Ophthalmology 85: 415–427
Eifrig DE (1980) Deposits on the surface of intraocular lenses. South Med J 73: 6–8
Goder GJ, Völker-Dieben HJ (1985) Microscopic-cytologic investigations on explanted intraocular lenses. Acta Ophthalmol (Copenh) 63: 64–72
Goldstein MN (1954) Formation of giant cells from human monocytes cultivated on cellophane. Anat Rec 118: 577–592
Hulliger L (1956) Über die unterschiedlichen Entwicklungsfähigkeiten der Zellen des Blutes und der Lymphe. Virchow's Arch [A] 329: 289–318
Kappelhof JP, Vrensen GF, de Jong PT, Pameyer JH, Willekens BL (1986) Cytology of human intraocular lenses. A scanning electron microscopic study. Ophthalmic Res 18: 75–80
Krey H, Jacobi KW (1978) Oberflächenstrukturen künstlicher Linsen im Rasterelektronenmikroskop. Ber Dtsch Ophthalmol Ges 75: 47–48
Leber Th (1888) Über die Entstehung der Entzündung und die Wirkung der entzündungserregenden Schädlichkeiten. Fortschr Med 6: 460–464
Leder LD (1967) Der Blutmonozyt. Springer, Berlin Heidelberg New York
Oak SS, Laing RA, Neubauer L, Nogawa H, Majima Y (1983) Clinical examination of the crystalline lens by retrocorneal specular microscopy. Ophthalmology 90: 346–351
Ohara K (1985) Biomicroscopy of surface deposits resembling foreign-body giant cells on implanted intraocular lenses. Am J Ophthalmol 99: 304–311
Ohara K (1986) Wide-field specular microscopy. J Ophthalm Photogr 9: 97–100
Puck A, Tso MOM, Yue B (1985) Cellular deposits on intraocular lenses. Acta Ophthalmol (Copenh) 63: 54–60
Ratner BD (1983) Analysis of surface contaminants on intraocular lenses. Arch Ophthalmol 101: 1434–1438
Recklinghausen F von (1863) Über Eiter und Bindegewebskorperchen. Virchow's Arch [A] 28: 157–197
Ridley H (1951) Intra-ocular acrylic lenses. Trans Ophthalmol Soc UK 1951: 617–621
Rintelen F, Saubermann G (1956) Pathohistologische Untersuchungen nach Kunststofflinsenimplantation beim Menschen Ophthalmologica 131: 369–373
Schlote HW, Grüngreiff J, Kemnitz P (1988) Histologische und zytologische Veränderungen des vorderen Augenabschnittes nach IOL-Implantation. In: Jacobi KW (ed) 1. Kongreß der DGII. Springer, Berlin Heidelberg New York, pp 20–24
Siepser SB, Kline OR (1983) Scanning electron microscopy of removed intraocular lenses. J Am Intraocul Implant Soc 9: 176–183
Sievers H, Domarus D von (1985) foreign-body reaction against intraocular lenses. Am J Ophthalmol 97: 743–751
Smith R (1956) Histopathological studies of eyes enucleated after failure of intra-ocular acrylic lens operations. Br J Ophthalmol 40: 473–479
Sugar J, Burnett J, Forstot SL (1978) Scanning electron microscopy of intraocular lens and endothelial cell interaction. Am J Ophthalmol 86: 157–161
Theobald GD (1953) In regard to the Ridley implant. Am J Ophthalmol 36: 1471
Vogt A (1930) Lehrbuch und Atlas der Spaltlampenmikroskopie des lebenden Auges. 2nd edn. Springer, Berlin Heidelberg New York
Wenzel M, Machata G (1988) Zellbewegungen auf intraokularen Linsen. In: Jacobi KW (ed) 1. Kongreß der DGII. Springer, Berlin Heidelberg New York, pp 25–31
Wenzel M, Böcking A, Teping Ch, Hunold W (1987) Biomicroscopy of an intraocular lens implant. Comparison of specular microscopic examination and cytology of a specimen. Klin Monatsbl Augenheilkd 190: 422–424
Wolter JR (1982) Lens implant cytology. Ophthalmic Surg 13: 939–942
Wolter JR (1982) Foreign body giant cells on intraocular lens implants. Graefe's Arch Clin Exp Ophthalmol 219: 103–111
Wolter JR (1982) Cell life on the surface of lens implants. Graefe's Arch Clin Exp Ophthalmol 218: 244–249
Wolter JR (1983) Pseudophaco-anaphylactic endophthalmitis? Graefe's Arch Clin Exp Ophthalmol 220: 160–166
Wolter JR (1984) Bilateral attachment of corneal endothelium to lens implants in corneal collapse at death: a pseudophakic eye with a Fuchs' epithelioma. Graefe's Arch Clin Exp Ophthalmol 221: 142–148
Wolter JR, Kleberger E (1985) Surface reaction on a posterior chamber lens seven days after implantation. J Am Intraoc Implant Soc 11: 599–602
Wolter JR, Lichter PR (1983) Fibroblast-like cells on intraocular lens implants: phagocytosing erythrocytes. Br J Ophthalmol 67: 641–645
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Wenzel, M., Reim, M., Heinze, M. et al. Cellular invasion on the surface of intraocular lenses. In vivo cytological observations following lens implantation. Graefe's Arch Clin Exp Ophthalmol 226, 449–454 (1988). https://doi.org/10.1007/BF02170007
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DOI: https://doi.org/10.1007/BF02170007