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Lens-Associated Glaucomas

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Albert and Jakobiec's Principles and Practice of Ophthalmology

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Abstract

Abnormalities of the crystalline lens may incite elevation of intraocular pressure often accompanied by significant intraocular inflammation. These pathologic conditions are traditionally known as phacogenic or lens-induced glaucomas (Appleton, Lowrey, Am J Ophthalmol 47:682, 1959). Three of these entities, (1) phacolytic glaucoma, (2) lens particle glaucoma, and (3) lens-induced uveitis or phacoanaphylaxis, are considered secondary open-angle glaucomas since they are associated with obstruction of aqueous outflow at the level of the trabecular meshwork. In contrast, phacomorphic glaucoma and lens displacement glaucoma are considered secondary narrow-angle glaucomas, as they result in narrowing of the iridocorneal angle due to pretrabecular outflow obstruction from either anterior displacement of the lens–iris diaphragm or pupillary block.

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References

  1. Appleton B, Lowrey A Jr. Phacogenic glaucoma. Am J Ophthalmol. 1959;47:682.

    Article  Google Scholar 

  2. Flocks M, Littwin CS, Zimmerman LE. Phacolytic glaucoma. Arch Ophthalmol. 1955;54:37.

    Article  CAS  Google Scholar 

  3. Goldberg MF. Cytological diagnosis of phacolytic glaucoma utilizing Millipore filtration of the aqueous. Br J Ophthalmol. 1967;51:847.

    Article  CAS  Google Scholar 

  4. Brooks AMV, Grant G, Gillies WE. Comparison of specular microscopy and examination of aspirate in phacolytic glaucoma. Ophthalmology. 1990;97:85.

    Article  CAS  Google Scholar 

  5. Rosenbaum JT, Samples JR, Seymour B, et al. Chemotactic activity of lens proteins and the pathogenesis of phacolytic glaucoma. Arch Ophthalmol. 1987;105:1582.

    Article  CAS  Google Scholar 

  6. Epstein DL, Jedziniak JA, Grant WM. Obstruction of aqueous outflow by lens particles and by heavy-molecular-weight soluble lens proteins. Invest Ophthalmol Vis Sci. 1978;17:272.

    CAS  PubMed  Google Scholar 

  7. Epstein DL, Jedziniak JA, Grant WM. Identification of heavy-molecular-weight soluble protein in aqueous humor in human phacolytic glaucoma. Invest Ophthalmol Vis Sci. 1978;17:398.

    CAS  PubMed  Google Scholar 

  8. Bartholomew RS, Rebello PF. Calcium oxalate crystals in aqueous. Am J Ophthalmol. 1979;88:1026.

    Article  CAS  Google Scholar 

  9. Lane SS, Kopietz LA, Lindquist TD, et al. Treatment of phacolytic glaucoma with extracapsular cataract extraction. Ophthalmology. 1988;95:749.

    Article  CAS  Google Scholar 

  10. Mandal AK, Gothwal VK. Intraocular pressure control and visual outcome in patients with phacolytic glaucoma managed by extracapsular cataract extraction with or without posterior chamber intraocular lens implantation. Ophthalmic Surg Lasers. 1998;29:880–9.

    Article  CAS  Google Scholar 

  11. Lim MC, Doe EA, Vroman DT, et al. Late onset lens particle glaucoma as a consequence of spontaneous dislocation of an intraocular lens in pseudoexfoliation syndrome. Am J Ophthalmol. 2001;132:261–3.

    Article  CAS  Google Scholar 

  12. Epstein DL. Diagnosis and management of lens-induced glaucoma. Ophthalmology. 1982;89:227.

    Article  CAS  Google Scholar 

  13. Richter C, Epstein DL. Lens-induced open-angle glaucoma. In: Ritch R, Shields MB, Krupin T, editors. The glaucomas. St Louis: CV Mosby; 1989.

    Google Scholar 

  14. Verhoeff FH. Endophthalmitis phacoanaphylactica. In: Proceedings international congress of ophthalmology. Washington, DC; 1922. p. 177.

    Google Scholar 

  15. Apple DJ, Mamalis N, Steinmetz RL, et al. Phacoanaphylactic endophthalmitis associated extracapsular cataract extraction and posterior chamber intraocular lens. Arch Ophthalmol. 1984;102:1528.

    Article  CAS  Google Scholar 

  16. Nissen SH, Anderson P, Anderson HMK. Antibodies to lens antigen in cataracts after cataract surgery. Br J Ophthalmol. 1981;65:63.

    Article  CAS  Google Scholar 

  17. Perlman EM, Albert DM. Clinically unsuspected phacoanaphylaxis after ocular trauma. Arch Ophthalmol. 1977;95:244.

    Article  CAS  Google Scholar 

  18. Irvine SR, Irvine AR Jr. Lens-induced uveitis and glaucoma. I: endophthalmitis phacoanaphylactica. Am J Ophthalmol. 1952;35:177.

    Article  CAS  Google Scholar 

  19. deVeer JA. Bilateral endophthalmitis phacoanaphylacta. Arch Ophthalmol. 1953;49:607.

    Article  CAS  Google Scholar 

  20. Yip PP, Leung WY, Hon CY, Ho CK. Argon laser peripheral iridoplasty in the management of phacomorphic glaucoma. Ophthalmic Surg Lasers Imaging. 2005;36:286–91.

    Article  Google Scholar 

  21. Smith GT, Vakalis AN, Brittain GP, Casswell AG. Related articles, links vitrectomy for phacolytic glaucoma in a patient with homocystinuria. Am J Ophthalmol. 1999;128:762–3.

    Article  CAS  Google Scholar 

  22. Liebman JM, Ritch R. Glaucoma secondary to lens intumescence and dislocation. In: Ritch R, Shields MB, Krupin T, editors. The glaucomas. St Louis: CV Mosby; 1989.

    Google Scholar 

  23. Ardjomand N, Kolli H, Vidic B, et al. Pupillary block after phakic anterior chamber intraocular lens implantation. J Cataract Refract Surg. 2002;28:1080–1.

    Article  Google Scholar 

  24. Alio JL, de la Hoz F, Perez-Santonja JJ, et al. Phakic anterior chamber lenses for the correction of myopia: a 7-year cumulative analysis of complications in 263 cases. Ophthalmology. 1999;106:458–66.

    Article  CAS  Google Scholar 

  25. Sanders DR, Vukich JA, Doney K, Gaston M. Implantable contact Lens in treatment of myopia study group. U.S. Food and Drug Administration clinical trial of the implantable contact lens for moderate to high myopia. Ophthalmology. 2003;110:255–66.

    Article  Google Scholar 

  26. Kodjikian L, Gain P, Donate D, et al. Malignant glaucoma induced by a phakic posterior chamber intraocular lens for myopia. J Cataract Refract Surg. 2002;28:2217–21.

    Article  Google Scholar 

  27. Trindade F, Pereira F. Gonioscopic changes after ICL implantation in myopic eyes. J Cataract Refract Surg. 2002;28:1896–7.

    Article  Google Scholar 

  28. Smallman DS, Probst L, Rafuse PE. Pupillary block glaucoma secondary to posterior chamber phakic intraocular lens implantation for high myopia. J Cataract Refract Surg. 2004;30:905–7.

    Article  Google Scholar 

  29. Pineda-Fernandez A, Jaramillo J, Vargas J, et al. Phakic posterior chamber intraocular lens for high myopia. J Cataract Refract Surg. 2004;30:2277–83.

    Article  Google Scholar 

  30. R V, Tan CS, Kumar TT, Ravindran RD. Safety and efficacy of manual small incision cataract surgery for phacolytic glaucoma. Br J Ophthalmol. 2007 Mar;91(3):279–81.

    Article  Google Scholar 

  31. Lee JW, Lai JS, Yick DW, Tse RK. Retrospective case series on the long-term visual and intraocular pressure outcomes of phacomorphic glaucoma. Eye (Lond). 2010;24(11):1675–80.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Ophthalmology, Stanford University, Palo Alto, CA, USA

    Sophia Y. Wang

  2. Tufts Medical School, Boston, MA, USA

    Cynthia G. Mattox

  3. Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, CA, USA

    Yang Sun

  4. Palo Alto VA Medical Center, Palo Alto, CA, USA

    Yang Sun

Authors
  1. Sophia Y. Wang
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  2. Cynthia G. Mattox
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  3. Yang Sun
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Corresponding author

Correspondence to Yang Sun .

Editor information

Editors and Affiliations

  1. Casey Eye Institute, Oregon Health & Science, Portland, OR, USA

    Daniel M. Albert

  2. Department of Ophthalmology, Massachusetts Eye and Ear, Massachusetts General Hospital, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Joan W. Miller

  3. Department of Ophthalmology, University of Illinois College of Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Dimitri T. Azar

  4. Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA

    Lucy H. Young

Section Editor information

  1. New York Eye and Ear Infirmary of Mount Sinai, New York, USA

    James C. Tsai

  2. Department of Ophthalmology, Stanford University, Palo Alto, USA

    Yang Sun

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Wang, S.Y., Mattox, C.G., Sun, Y. (2022). Lens-Associated Glaucomas. In: Albert, D.M., Miller, J.W., Azar, D.T., Young, L.H. (eds) Albert and Jakobiec's Principles and Practice of Ophthalmology. Springer, Cham. https://doi.org/10.1007/978-3-030-42634-7_173

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  • DOI: https://doi.org/10.1007/978-3-030-42634-7_173

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-42633-0

  • Online ISBN: 978-3-030-42634-7

  • eBook Packages: MedicineReference Module Medicine

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