Summary
DNA sequences are generally not random sequences. To show such nonrandomness visually, DNA sequence data are often plotted as moving averages for a certain length of window slid along a sequence. Here a simple algorithm is presented for determining the window size and for finding a nonrandom region of sequence.
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Bernardi G, Olofsson B, Filipski J, Zerial M, Salinas J, Cuny G, Meunier-Rotival M, Rodier F (1985) The mosaic genome of warm-blooded vertebrates. Science 228:953–958
Brownlee KA (1965) Statistical theory and methodology in science and engineering. ed 2. John Wiley & Sons, New York
Efron B (1979) Bootstrap methods: another look at the jackknife. Ann Statist 7:1–26
Efron B,(1979) Bootstrap methods: another look at the jackknife. Ann Statist 7:1–26
Efron B, Gong G (1983) A leisurely look at the bootstrap, the jackknife, and cross-validation. Am Statist 37:36–48
Hughes AL, Nei M (1989) Pattern of nucleotide substitution at major histocompatibility complex class I loci reveals overdominant selection. Nature 335:167–170
Hughes AL, Nei M (1989) Nucleotide substitution at major histocompatibility complex class II loci: evidence for overdominant selection. Proc Natl Acad Sci USA 86:958–962
Ikemura T (1985) Codon usage and tRNA content in unicellular and multicellular organisms. Mol Biol Evol 2:13–34
Karlin S, Altschul SF (1990) Methods for assessing the statistical significance of molecular sequence features by using general scoring schemes. Proc Natl Acad Sci USA 87:2264–2268
Kimura M (1983) The neutral theory of molecular evolution. Cambridge University Press, Cambridge
Nei M, Hughes AL (1991) Polymorphism and evolution of the major histocompatibility complex loci in mammals. In: Selander RK, Clark AG, Whittam TS (eds) Evolution at the molecular level. Sinauer, Sunderland MA, pp 222–247
von Neuman J, Kent RH, Bellinson HR, Hart BI (1941) The mean square successive difference. Ann Math Statist 12:153–162
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Tajima, F. Determination of window size for analyzing DNA sequences. J Mol Evol 33, 470–473 (1991). https://doi.org/10.1007/BF02103140
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DOI: https://doi.org/10.1007/BF02103140