Summary
The stochastic model of molecular evolution was used to makea priori predictions for the total number of one-step nucleotide changes required to account for a given number of amino acid substitutions between two homologous proteins. These predictions are now found to be concordant with empirical data summarized by Dayhoff, Eck and Park (1969). Correction factors are derived for adjusting the “leg lengths” of phylogenetic trees. It is shown that the operations of constructing the phylogenetic tree and applying the correction algorithm are not commutative with respect to obtaining the leg lengths. The effect of this on certain published phylogenies is discussed. It is suggested that, as a first approximation, at any given point in evolutionary time, enthalpic (selective) forces determine the number and position of those codon sites which are free to vary, whereas within these variable sites, entropic (random) processes determine the course of evolution at the molecular level.
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Dayhoff, M. O., Eck, R. V., Park, C. M.: Atlas of protein sequence and structure, vol. 4, Section 9, National Biomedical Research Foundation, Silver Spring, Maryland 1969.
Dayhoff, M. O., Park, C. M.: Atlas of protein sequence and structure, vol. 4, Section 2, p. 13, National Biomedical Research Foundation, Silver Spring, Maryland 1969.
Dickerson, R. E.: J. molec. Evolution1, 26 (1971).
Feller, W.: An introduction to probability theory and its application, Chapter 15. New York: John Wiley & Sons Inc. 1968.
Fitch, W. M.: J. molec. Evolution1, 84 (1971).
Fitch, W. M., Margoliash, E.: Science155, 279 (1967).
Fitch, W. M., Margoliash, E.: Evolutionary Biology4, 579 (1970).
Fitch, W. M., Markowitz, E.: Biochem. Genet.4, 579 (1970).
Holmquist, R.: J. molec. Evolution1, 115 (1972a).
Holmquist, R.: J. molec. Evolution1, 134 (1972b).
Holmquist, R., Cantor, C., Jukes, T.: J. molec. Biol.64, 145 (1972).
Jukes, T. H.: Advanc. biol. med. Phys.9, 1 (1963).
Jukes, T. H., Holmquist, R.: J. molec. Biol.64, 163 (1972).
King, J. L., Jukes, T. H.: Science164, 788 (1969).
Koch, R. E.: Proc. nat. Acad. Sci. (Wash.)68, 773 (1971).
McLachlan, A. D.: J. molec. Biol.61, 409 (1971).
Sarich, V. M.: Old world monkeys (J. R. Napier and P. H. Napier, eds.), p. 190. NewYork: Academic Press 1970.
Vogel, H., Zuckerkandl, E.: Biochemical evolution and the origin of life (E. Schof-feniels, ed.), p. 352. North Holland Publishing Company 1971.
Wilson, A. C., Sarich, V. M.: Proc. nat. Acad. Sci. (Wash.)63, 1088 (1969).
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Holmquist, R. Empirical support for a stochastic model of evolution. J Mol Evol 1, 211–222 (1972). https://doi.org/10.1007/BF01660240
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DOI: https://doi.org/10.1007/BF01660240