Abstract
Three human rasfamily protooncogenes, c-Ki-ras-1, and c-Ki-ras-2, and N-ras,have been mapped to chromosome bands 6p11–12, 12p11.1–12.1, and 1p11–13, respectively by in situ molecular hybridization. Certain human cancers display consistent and specific alterations involving chromosomes 1, 6, and 12. The precise chromosomal localization of ras genes will permit evaluation of thepossible effect of these chromosome changes on the structure and activities of ras protooncogenes in human neoplasia.
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Literature cited
Weinberg, R.A. (1982).Cell 30:3–4.
Cooper, G.M. (1982).Science 217:801–806.
Pulciani, S., Santos, E., Lauver, A.V., Long, L.K., Aaronson, S.A., and Barbacid, M. (1982).Nature 300:539–542.
Santos, E., Tronick, S.R., Aaronson, S.A., Pulciani, S., and Barbacid, M. (1982).Nature 298:343–347.
Der, C.J., Krontiris, T.G., and Cooper, G.M. (1982).Proc. Natl. Acad. Sci. U.S.A. 79:3637–3640.
Shimizu, K., Goldfarb, M., Perucho, M., and Wigler, M. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:383–387.
Parada, L.F., Tabin, C.J., Shih, C., and Weinberg, R.A. (1982).Nature 297:474–478.
Eva, A., Tronick, S.R., Gol, R.A., Pierce, J.H., and Aaronson, S.A. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:4926–4930.
Chang, E.H., Gonda, M.A., Ellis, R.W., Scolnick, E.M., and Lowy, D.R. (1982).Proc. Natl. Acad. Sci. U.S.A. 79:4848–4852.
Taparowsky, E., Shimizu, K., Goldfarb, M., and Wigler, M. (1983).Cell 34:581–586.
Shimizi, K., Birnbaum, D., Ruley, M.A., Fasano, O., Suard, Y., Edlund, L., Taparowsky, E., Goldfarb, M., and Wigler, M. (1983).Nature 304:497–500.
Reddy, E.P. (1983).Science 220:1061–1063.
Capon, D.J., Seeburg, P.H., McGrath, J.P., Hayflick, J.S., Edman, U., Levinson, A.D., and Goeddel, D.V. (1983).Nature 304:507–513.
McGrath, J.P., Capon, D.J., Smith, D.H., Chen, E.Y., Seeburg, P.H., Goeddel, D.V., and Levinson, A.D. (1983).Nature 304:501–506.
Yuasa, Y., Gol, R.A., Chang, A., Chiu, I.M., Reddy, E.P., Tronick, S.R., and Aaronson, S.A. (1984).Proc. Natl. Acad. Sci. U.S.A. 81:3670–3674.
Santos, E., Martin-Zanca, D., Reddy, E.P., Pierotti, M.A., Della Porta, G.,and Barbacid, M. (1984).Science 223:661–664.
Reddy, E.P., Reynolds, R.K., Santos, E., and Barbacid, M. (1982).Nature 300:149–152.
Taparowsky, E., Suard, Y., Fasano, O., Shimizu, K., Goldfarb, M., and Wigler, M. (1982).Nature 300:762–765.
Tabin, C.J., Bradley, S.M., Bargmann, C.I., Weinberg, R.A., Papageorge, A.G., Scolnick, E.M., Dhar, R., Lowy, D.R., and Chang, E.H. (1982).Nature 300:143–149.
Yuasa, Y., Srivastava, S.K., Dunn, C.Y., Rhin, J.S., Reddy, E.P., and Aaronson, S.A. (1983).Nature 303:775–779.
Fujita, J., Yoshida, O., Yuasa, Y., Rhim, J., Hatanaka, M., and Aaronson, S.A. (1984).Nature 309:464–466.
Kraus, M., Yuasa, Y., and Aaronson, S.A. (1984).Proc. Natl. Acad. Sci. U.S.A. 17:5384–5389.
Chang, E.H., Furth, M.E., Scholnick, E.M., and Lowy, D.R. (1982).Nature 297:479–483.
Stacey, D.W., and Kung, H.F. (1984).Nature 310:508–511.
McBride, O.W., Swan, D.C., Tronick, S.R., Gol, R., Klimanis, D., Moore, D.E., and Aaronson, S.A. (1983).Nucleic Acids Res. 11:8221–8236.
Yunis, J.J. and Chandler, M.E. (1977). InProgress in Clinical Pathology, Vol. VII, (eds.) Stefanini, M., Hossaini, A.A., and Isenberg, H.D. (Grune and Stratton, New York), pp. 267–288.
Harper, M.E., and Saunders, G.F. (1981).Chromosoma (Berlin) 83:431–439.
Chandler, M.E., and Yunis, J.J. (1978).Cytogenet. Cell Genet. 22:352–356.
ISCN (1981).An International System for Human Cytogenetic Nomenclature—High-Resolution Banding (1981) Birth Defects: Original Article Series, Vol. 17, No. 5 (March of Dimes Birth Defects Foundation, New York).
O'Brien, S.J., Nash, W.G., Goodwin, J.L., Lowy, D.R., and Chang, E.H. (1983).Nature 302:839–842.
Ryan, J., Barker, P.E., Shimizu, K., Wigler, M., and Ruddle, F.H. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:4460–4463.
Sakaguchi, A.Y., Naylor, S.L., Shows, T.B., Toole, J.J., McCoy, M., and Weinberg, R.A. (1983).Science 219:1081–1083.
Jhanwar, S.C., Neel, B.G., Hayward, W.S., and Chaganti, R.S.K. (1983).Proc. Natl. Acad. Sci. U.S.A. 80:4794–4797.
Huerre, C., Despoisse, S., Gilgenkrantz, S., Lenoir, G.M., and Junien, C. (1983).Nature 305:638–641.
de Martinville, B., Giacalone, J., Shih, C., Weinberg, R.A., and Francke, U. (1983).Science 219:498–501.
Fearon, E.R., Antonarakis, S.E., Meyers, D.A., and Levine, M.A. (1984).Am. J. Hum. Genet. 36:329–337.
Comings, D.E. (1972).Nature 238:455–457.
de Martinville, B., Cunningham, J.M., Murray, M.J., and Francke, U. (1983).Nucleic Acid Res. 11:5267–5275.
Hall, A., Marshall, C.J., Spurr, N.K., and Weiss, R.A. (1983).Nature 303:396–400.
Davis, M., Malcolm, S., Hall, A., and Marshall, C.J. (1983).EMBO J. 2:2281–2283.
Rabin, M., Watson, M., Barker, P.E., Ryan, J., Breg, W.R., and Ruddle, F.H. (1984).Cytogenet. Cell Genet. 38:70–72.
Rowley, J.D. (1983).Nature 301:290–291.
Lebeau, M.M., and Rowley, J.D. (1984).Nature 308:607–608.
Mitelman, F., and Levan, G. (1981).Hereditas 95:79–139.
Yunis, J.J. (1983).Science 221:227–236.
Balaban, G., and Gilbert, F. (1982).Cancer Res. 42:1832–1842.
Babapulle, V.B., and Atkin, N.B. (1981).Cancer Genet. Cytogenet. 4:215–225.
Haag, M.M., Soukup, S.W., and Neeley, J.E. (1981).Cancer Res. 41:2995–2999.
Brodeur, G.M., Green, A.A., Hayes, F.A., Williams, K.J., Williams, D.L., and Tsiatis, A.A. (1981).Cancer Res. 41:4678–4686.
Gilbert, F., Balaban, G., Moorhead, P., Bianchi, D., and Schlesinger, H. (1982).Cancer Genet. Cytogenet. 7:33–42.
Benedict, W.F., Banerjee, A., Mark, C., and Murphree, A.L. (1983).Cancer Genet. Cytogenet. 10:311–333.
Squire, J., Phillips, R.A., Boyce, S., Godbout, R., Rogers, B., and Gallie, B.L. (1984).Hum. Genet. 66:46–53.
Becher, R., Gibas, Z., Karakousis, C., and Sandberg, A.A. (1983).Cancer Res. 43:5010–5016.
Becher, R., Gibas, Z. and Sandberg, A.A. (1982).Cancer Genet. Cytogenet. 5:173–179.
Lewis, M.G., Ikonopisov, R.L., Nairn, R.C., Phillips, T.M., Fairley, G.H., Bodenham, D.C., and Alexander, P. (1969).Br. Med. J. 3:547–552.
Mavligit, G., Gutterman, J.U., McBride, C., and Hersh, E.M. (1974).Prog. Exp. Tumor Res. 19:222–252.
Francke, U., and Pellegrino, M.A. (1977).Proc. Natl. Acad. Sci. U.S.A. 74:1147–1151.
Schwab, M., Alitalo, K., Varmus, H.E., and Bishop, J.M. (1983).Nature 303:497–501.
Reeve, A.E., Housiaux, P.J., Gardner, R.J.M., Chewings, W.E., Grindley, R.M., and Millow, L.J. (1984).Nature 309:174–176.
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Popescu, N.C., Amsbaugh, S.C., DiPaolo, J.A. et al. Chromosomal localization of three humanras genes by in situ molecular hybridization. Somat Cell Mol Genet 11, 149–155 (1985). https://doi.org/10.1007/BF01534703
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DOI: https://doi.org/10.1007/BF01534703