Summary
Three cases of pleomorphic xanthoastrocytoma (PXA), one of which showed anaplastic evolution, are described. In all three the PXA tumors were well circumscribed and could be totally removed. Light-microscopically, pleomorphic tumor cells clustered gregariously and often formed alveolar structures. Electron microscopy revealed various epithelial properties, such as junctions and interdigitations between apposing tumor cells, and prominent basal laminae surrounding tumor nests. The circumscribed growth of PXA, as contrasted with an infiltrative growth of usual astrocytoma, can be attributed to the cellular cohesion based on the epithelial properties of the tumor cells. In the third patient, tumor recurred 6 months postoperatively. Although the recurrent tumor retained the alveolar structures, pleomorphism and various degenerative features of the tumor cells diminished with advance in the proliferative activities.
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Banerjee SD, Cohn RH, Bernfield MR (1977) Basal lamina of embryonic salivary epithelia. Production by the epithelium and role in maintaining lobular morphology. J Cell Biol 73:445–463
Bukeo T, Nakamura S, Nishimoto A, Tabuchi K (1985) Pleomorphic xanthoastrocytoma (Kepes): a case report (in Japanese). Neurol Surg 13:773–777
Dekker A, Krause JR (1973) Hyaline globules in human neoplasms. Arch Pathol 95:178–181
Foidart JM, Bere EW, Yaar M (1980) Distribution and immunoelectron microscopic localization of laminin, a noncollagenous basement membrane glycoprotein. Lab Invest 42:336–342
Gomez JG, Garcia JH, Cohon LE (1985) A variant of cerebral glioma called pleomorphic xanthoastrocytoma: case report. Neurosurgery 16:703–706
Grant JW, Gallagher PJ (1986) Pleomorphic xanthoastrocytoma—Immunohistochemical methods for differentiation from fibrous histocytomas with similar morphology. Am J Surg Pathol 10:336–341
Jones MC, Drut R, Raglia G (1983) Pleomorphic xanthoastrocytoma: a report of two cases. Pediatr Pathol 1:459–467
Kepes JJ, Rubinstein LJ, Eng LF (1979) Pleomorphic xanthoastrocytoma: a distinctive meningocerebral glioma of young subjects with relatively favorable prognosis. A study of 12 cases. Cancer 44:1839–1852
Kepes JJ, Fulling KH, Garcia JH (1982) The clinical significance of “adenoid” formations of neoplastic astrocytes, imitating metastatic carcinoma, in gliosarcomas. A review of five cases. Clin Neuropathol 1:139–150
Kepes JJ, Sher J, Oliver MG (1985) Light and electron microscopic study of “adenoid” components in gliomas. Fibroblastic activity of neoplastic astrocytes. J Neuropathol Exp Neurol 44:359
Kuhajda FP, Mendelsohn G, Taxy JB, Long DM (1981) Pleomorphic xanthoastrocytoma: report of a case with light and electron microscopy. Ultrastruct Pathol 2:25–32
Kuramitsu M, Sawa H, Takeshita I, Iwaki T, Kato K (1981) Neuronspecific γ-enolase derived from human glioma. Neurochem Pathol 4:89–105
Kusaka H, Hirano A, Bornstein MB, Raine CS (1985) Basal lamina formation by astrocytes in organotypic cultures of mouse spinal cord tissue. J Neuropathol Exp Neurol 44:295–303
Lyser KM (1972) The differentiation of glial cells and glia limitans in organ cultures of chick spinal cord. In Vitro 8:77–84
Maleki M, Robitaille Y, Bertrand G (1983) Atypical xanthoastrocytoma presenting as a meningioma. Surg Neurol 20:235–238
Mannoji H, Takeshita I, Fukui M, Ohta M, Kitamura K (1981) Glial fibrillary acidic protein in medulloblastoma. Acta Neuropathol (Berl) 55:63–69
Nabeshima S, Reese TS, Landis DMD, Brightman MW (1975) Junctions in the meninges and marginal glia. J Comp Neurol 164:127–170
Palma L, Maleci A, Lorenzo ND, Lauro GM (1985) Pleomorphic xanthoastrocytoma with 18-year survival. Case report. J Neursurg 63:808–810
Peters A, Palay SL, Webser H deF (1976) The fine structure of the nervous system: the neurons and supporting cells. Saunders, Philadelphia, pp 233–248
Rubinstein LJ (1972) Tumors of the central nervous system, 2nd series. AFIP, Washington, pp 33–34
Russell DS, Rubinstein LJ (1977) Pathology of tumors of the nervous system. 4th edn. Arnold, London, pp 183–188
Sakai H, Kawano N, Okada K, Tanabe T, Yada K, Yagishita S (1981) A case of pleomorphic xanthoastrocytoma (Kepes) (in Japanese). Neurol Surg 9:1519–1524
Sawa H, Takeshita I, Kuramitsu M, Mannoji H, Machi T, Fukui M, Kitamura K (1987) Neuronal and glial proteins in medulloblastomas. Immunohistochemical study. Anticancer Res 6:905–910
Schiffer D, Giordana MT, Mauro A, Migheli A (1984) GFAP, F VIII/RAg, laminin, and fibronectin in gliosarcomas: an immunohistochemical study. Acta Neuropathol (Berl) 63:108–116
Strøm EH, Skullerud K (1983) Pleomorphic xanthoastrocytoma: report of 5 cases. Clin Neuropathol 2:188–191
Weldon-Linne CM, Victor TA, Groothuis DR, Vick NA (1983) Pleomorphic xanthoastrocytoma. Ultrastructural and immunohistochemical study of a case with a rapidly fatal outcome following surgery. Cancer 52:2055–2063
Yamashita M, Takeshita I, Mannoji H, Egami H, Ohta M, Kitamura K (1981) Establishment and maintenance of a human glioma transplanted serially to hereditary asplenicathymic (Lasat) mice. Exp Cell Biol 49:41–53
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Supported in part by grant in aid 60480328 from the Ministry of Education, Science, and Culture, Japan
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Iwaki, T., Fukui, M., Kondo, A. et al. Epithelial properties of pleomorphic xanthoastrocytomas determined in ultrastructural and immunohistochemical studies. Acta Neuropathol 74, 142–150 (1987). https://doi.org/10.1007/BF00692844
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DOI: https://doi.org/10.1007/BF00692844