Summary
Blood flow in arteries supplying cutaneous and intestinal vascular regions were simultaneously measured with an electromagnetic flowmeter in anesthetized dogs, paralyzed with succinyl choline. The hypothalamic preoptic region was selectively heated and cooled by means of a stereotaxically inserted, water perfused thermode.
Skin blood flow increased during hypothalamic heating and was reduced during hypothalamic cooling. Conversely, intestinal blood flow decreased during heating and increased during cooling. Arterial pressure was not influenced by hypothalamic cooling and decreased slightly during heating.
The changes of blood flow distribution observed in the experiments are in keeping with the results obtained during selective spinal cord heating and cooling. It is assumed that antagonistic changes of blood flow in the cutaneous and intestinal vascular beds represent typical thermoregulatory responses of systemic circulation induced by regionally antagonistic changes of vasomotor activity.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Andersson, B., Grant, R., Larsson, S.: Central control of heat loss mechanisms in the goat. Acta physiol. scand.37, 261–280 (1956).
—, Larsson, B.: Influence of local temperature changes in the preoptic area and rostral hypothalamus on the regulation of food and water intake. Acta physiol. scand.52, 75–89 (1961).
Barbour, H. G.: Die Wirkung unmittelbarer Erwärmung und Abkühlung der Wärmezentra auf die Körpertemperatur. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak.70, 1–15 (1912).
Calvelo, M. G., Abboud, F. M., Ballard, D. R., Abdel-Sayed, W.: Reflex vascular responses to stimulation of chemoreceptors with nicotine and cyanide. Circulat. Res.27, 259–276 (1970).
Djojosugito, A. M., Folkow, B., Kylstra, P. H., Lisander, B., Tuttle, R. S.: Differentiated interaction between the hypothalamic defence reaction and baroreceptor reflexes. Acta physiol. scand.78, 376–385 (1970).
Eliasson, S., Ström, G.: On the localization in the cat of hypothalamic and cortical structures influencing cutaneous blood flow. Acta physiol. scand.20, Suppl. 70, 113–118 (1950).
Folkow, B., Ström, G., Uvnäs, B.: Cutaneous vasodilatation elicited by local heating of the anterior hypothalamus in cats and dogs. Acta physiol. scand.17, 317–326 (1949a).
———: Efferent nervous pathways involved in cutaneous vasodilatation induced by activation of hypothalamic heat loss mechanisms. Acta physiol. scand.17, 327–338 (1949b).
Freeman, W. J., Davis, D. D.: Effects on cats of conductive hypothalamic cooling. Amer. J. Physiol.197, 145–148 (1959).
Gale, C. C., Mathews, M., Young, J.: Behavioral thermoregulatory responses to hypothalamic cooling and warming in baboons. Physiol. Behav.5, 1–6 (1970).
Glaser, E. M.: The effects of cooling and warming on the vital capacity, forearm and hand volume, and skin temperature of man. J. Physiol. (Lond.)109, 421–429 (1949).
Grayson, J.: Vascular reactions in the human intestine. J. Physiol. (Lond.)109, 439–447 (1949).
Hardy, J. D.: Brain sensors of temperature. Brody Memorial Lecture VIII, University of Missouri-Columbia (1969).
Hemingway, A., Rasmussen, T., Wikoff, H., Rasmussen, A. T.: Effects of heating hypothalamus of dogs by diathermy. J. Neurophysiol.3, 329–338 (1940).
Iriki, M., Riedel, W., Simon, E.: Regional differentiation of sympathetic activity during hypothalamic heating and cooling in anesthetized rabbits. Pflügers Arch. (in press) (1971).
Jessen, C., Mayer, E. Th.: Spinal cord and hypothalamus as core sensors of temperature in the conscious dog. Pflügers Arch.324, 189–204 (1971).
Krüger, F. J., Kundt, H. W., Hensel, H., Brück, K.: Das Verhalten der Hautdurchblutung bei Hypothalamuskühlung an der wachen Katze. Pflügers Arch. ges. Physiol.269, 240–247 (1959).
Kullmann, R., Schönung, W., Simon, E.: Antagonistic changes of blood flow and sympathetic activity in different vascular beds following thermal stimulation. I. Blood flow in skin, muscle and intestine during spinal cord heating and cooling in anesthetized dogs. Pflügers Arch.319, 146–161 (1970).
Lisander, B.: Factors influencing the autonomic component of the defence reaction. Acta physiol. scand., Suppl.351 (1970).
Müller, O., Veiel, E.: Beiträge zur Kreislaufphysiologie des Menschen, besonders zur Lehre von der Blutverteilung. Sammlg. klin. Vortr., Inn. Med. Nr. 194-196; S. 641–724. Leipzig: J. A. Barth 1910.
Prince, A. L., Hahn, L. J.: The effect on the volume of the hind limb induced by heating and cooling the corpus striatum of the rabbit. Amer. J. Physiol.46, 416–419 (1918).
Rautenberg, W., Simon, E., Thauer, R.: Die Bedeutung der Kerntemperatur für die chemische Temperaturregulation beim Hund in leichter Narkose. II. Isolierte Senkung der Hirntemperatur. Pflügers Arch. ges. Physiol.278, 350–360 (1963).
Rein, H.: Vasomotorische Regulationen. Ergebn. Physiol.32, 28–72 (1931).
Schönung, W., Jessen, C., Wagner, H., Simon, E.: Regional blood flow antagonism induced by central thermal stimulation in the conscious dog. Experientia (in press) (1971).
Singer, M.: The brain of the dog in section. Philadelphia-London: W. B. Saunders 1962.
Söderberg, U.: Changes in muscle circulation elicited by local heating of hypothalamus. Experientia (Basel)12, 299–300 (1956a).
Söderberg, U.: Vaso-motor effects in the thyroid gland elicited by local hypothalamic heating in cats. Abstr. of 20. Internat. Physiol. Congr., Brüssel, p. 839 (1956b).
Ström, G.: Vasomotor responses to thermal and electrical stimulation of frontal lobe and hypothalamus. Acta physiol. scand.20, Suppl. 70, 83–112 (1950a).
—: Influence of local thermal stimulation of the hypothalamus of the cat on cutaneous blood flow and respiratory rate. Acta physiol. scand.20, Suppl. 70, 47–76 (1950b).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Schönung, W., Wagner, H., Jessen, C. et al. Differentiation of cutaneous and intestinal blood flow during hypothalamic heating and cooling in anesthetized dogs. Pflugers Arch. 328, 145–154 (1971). https://doi.org/10.1007/BF00592442
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00592442