Summary
Muscle cell leakage and hormonal changes were compared immediately after and during the 3 days following a 24 h endurance run (R24 h) in 8 subjects, and a 10 h triathlon non-competitive race (T10 h) in 6 subjects. The study showed three main differences: 1) plasma enzyme increases were considerably more significant in R24 h than in T10 h: compared with resting levels, creatine kinase increased ×120 after R24 h but only ×2 after T10 h; lactic dehydrogenase ×4, as opposed to ×1.5; and transaminases only showed an increase after R24 h. The plasma myoglobin increase after R24 h was double that found after T10 h; 2) for the same magnitude of plasma aldosterone and cortisol after R24 h and T10 h (3 times the resting levels), a highly significant decrease in urinary Na+ (p<0.001) and an increase in urinary K+ (p<0.01) were found only after R24 h; and 3) the plasma free noradrenaline level increased significantly after R24 h (×2.6) whereas it was unchanged after T10 h. In contrast, the plasma level of conjugated dopamine increased only after T10 h (×3.7, p<0.05). These results suggest that long-distance running causes more muscular lesions than the triathlon, and that important factors other than aldosterone are probably involved in the regulation of urinary electrolyte excretions during T10 h.
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Allenmark S, Hedman L, Söderberg A (1980) Microanalysis of catecholamines in human plasma by high performance liquid chromatography with amperometric detection as compared with a radioenzymatic method. Microchem J 25:567–575
Anderson J, Bloom S, Somers V, Conway J, Sleight P (1986) Hyponatremia and ultra marathons. JAMA 256:213–214
Bedu M, Roche D, Borel A-M, Falgairette G, Fellmann N, Pequignot J-M, Chamoux A, Coudert J (1987) A propos d'un record mondial de durée (81 heures) sur planche à voile. Sci Sports 2:35–36
Claustre J, Serusclat P, Peyrin L (1983) Glucoronide and sulfate catecholamine conjugates in rat and human plasma. J Neural Transmission 56:265–278
Costill D-L, Branam G, Fink W, Nelson R (1976) Exercise induced sodium conservation: changes in plasma renin and aldosterone. Med Sci Sports 8:209–213
Demos M, Gitin E, Kagen L (1974) Exercise myoglobulinemia acute exertional rhabdomyolysis. Arch Int Med 134:669–673
Dessypris A, Wägar G, Fyhrquist F, Mäkinen T, Welin M-G, Lamberg B-A (1980) Marathon run: effects on blood cortisol-ACTH, iodothyronine-TSH and vasopressin. Acta Endocrinol 95:151–157
Galun E, Epstein Y (1984) Serum creatine kinase activity following a 120 km march. Clin Chem Acta 143:281–283
Goldstein DS, Feuerstein GZ, Kopin U, Keiser HR (1981) Validity of liquid chromatography with electrochemical detection for measuring dopamine in human plasma. Clin Chim Acta 117:113–120
Guezennec C-Y, Giaoui M, Voignier J-P, Legrand H, Fournier E (1986) Evolution des taux plasmatiques des LDH (lactico-deshydrogenase), CPK (créatine phosphokinase) et de la myoglobine à l'issue d'une course de 100 km et d'un triathlon. Sci Sports 1:255–263
Haibach H, Hosler M-W (1985) Serum creatine kinase in marathon runners. Experientia 41:39–40
Hikida R, Staron R, Hagerman F, Sherman W, Costill D (1983) Muscle fiber necrosis associated with human marathon runners. J Neurol Sci 59:185–203
Holly R, Barnard R, Rosenthal M, Applegate E, Pritikin N (1986) Triathletes characterization and response to prolonged strenuous competition. Med Sci Sports Exerc 18:123–127
Keul J, Kohler G, von Glutz G, Lüthi U, Berg A, Howald H (1981) Biochemical changes in a 100 km run: carbohydrates, lipids, and hormones in serum. Eur J Appl Physiol 47:181–189
Kielblock A, Manjoo M, Booyens J, Katzeff I (1979) Creatine phosphokinase and lactate dehydrogenase levels after ultra long distance running. S Afr Med J 55:1061–1064
Kosano H, Kinoshita T, Nagata N, Takatani O, Isobe M, Yasaki Y (1986) Change in concentrations of myogenic components of serum during 93 h of strenuous physical exercise. Clin Chem 32:346–348
Kuchel O, Buu NT (1985) Circadian variations of free and sulfo-conjugated catecholamines in normal subjects. Endocr Res 11:17–25
Lehmann M, Keul J (1986) Age-associated changes of exercise-induced plasma catecholamine responses. Eur J Appl Physiol 55:302–306
Lepage L, Galimany R (1985) Créatinine: interférences analytiques et effets pharmacologiques. In: Siest G, Galteau MM, Schiele F, Henny J (eds) Examens de laboratoire et médicaments. Interférences analytiques et varations pharmacologiques. Expansion Scientifique Française, Nancy, pp 90–98
Lijnen P, Hespel P, Vanden Eynde E, Amery A (1985) Urinary excretion of electrolytes during prolonged physical activity in normal man. Eur J Appl Physiol 53:317–321
Noakes T, Kotzenberg G, McArthur P, Dykman J (1983) Elevated serum creatine kinase MB and creatine kinase BB-isoenzyme fractions after ultra marathon running. Eur J Appl Physiol 52:75–79
Nørregaard Hansen K, Bjerre-Knudsen J, Brodthagen U, Jordal R, Paulev P-E (1982) Muscle cell leakage due to long distance training. Eur J Physiol 48:177–188
Opstad P-K, Øktedalen O, Aakvaag A, Fonnum F, Lund P-K (1985) Plasma renin activity and serum aldosterone during prolonged physical strain. Eur J Appl Physiol 54:1–6
Racz K, Kuchel O, Buu N-T, Debinski N, Cantin M, Genest J (1986) Atrial natriuretic factor, catecholamines, and natriuresis. N Engl M Med 314:321–322
Roxin L, Hedin G, Venge P (1986) Muscle cell leakage of myoglobin after long-term exercise and relation to the individual performances. Int J Sports Med 7:259–263
Schneider E, Davis J, Baumber J, Johnson J (1970) The hepatic metabolism of renin and aldosterone. Circ Res [Suppl I) 26–27:175–183
Symanski J, Mc Murray R, Silverman L, Smith B, Siegel A (1983) Serum creatine kinase and CK-MB isoenzyme responses to acute and prolonged swimming in trained athletes. Clin Chim Acta 129:181–187
Szasz G, Gruber W, Bernt F (1976) Creatine kinase in serum: 1. Determination of optimum reaction conditions. Clin Chem 22:650–654
Thomas B, Motley C (1984) Myoglobinemia and endurance exercise: a study of twenty-five participants in a triathlon competition. Am J Sports Med 12:113–119
Viru A, Körge P (1971) Metabolic processes and adreno-cortical activity during marathon races. In Z Angew Physiol 29:173–183
Wade C, Hill L, Hunt M, Dressendorfer R (1985) Plasma aldosterone and renal function in runners during a 20-days road race. Eur J Appl Physiol 54:456–460
Wroblewski F, La Due J (1955) Lactic dehydrogenase activities in blood. Proc Soc Exp Biol Med NY 90:210–214
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Fellmann, N., Sagnol, M., Bedu, M. et al. Enzymatic and hormonal responses following a 24 h endurance run and a 10 h triathlon race. Europ. J. Appl. Physiol. 57, 545–553 (1988). https://doi.org/10.1007/BF00418460
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DOI: https://doi.org/10.1007/BF00418460