Abstract
An antibiotic-producing Chromobacter was isolated from a sea-water sample from the North Pacific Gyre. The bacterium produces 3 bromine-containing metabolites: tetrabromopyrrole, 2-(2′-hydroxy-3′, 5′-dibromophenyl)-3, 4, 5-tribromopyrrole, and hexabromo-2, 2′-bipyrrole. It also synthesizes n-propyl 4-hydroxybenzoate and 4-hydroxybenzaldehyde. Some of these compounds were shown to be responsible for autoinhibition of the Chromobacterium itself, as well as for antibiotic action against other kinds of bacteria.
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Buck, J.D., S.P. Meyers and K.M. Kamp: Marine bacteria with antiyeast activity. Science, N.Y. 138, 1339–1340 (1962)
Burkholder, P.R.: Biology and geology of coral reefs. Vol. II. In: The ecology of marine antibiotics and coral reefs, pp 117–182. Ed. by O.A. Jones and R. Endean. New York: Academic Press 1973
—, R.M. Pfister and F.M. Leitz: Production of a pyrrole antibiotic by a marine bacterium. Appl. Microbiol. 14, 649–653 (1966)
Collins, C.H.: Microbial methods, 404 pp. New York: Plenum Press 1967
Feiser, L.F. and M. Feiser: Reagents for organic synthesis. Vol. I. 1457 pp. New York: Wiley and Sons, Inc. 1968
Gibbs, B.M. and F.A. Skinner: Identification methods for microbiologists, Part A. 145 pp. New York: Academic Press 1966
Hamilton, R.D. and K.E. Austin: Physiological and cultural characteristics of Chromobacterium marinum. Antonie van Leeuwenhoek 33, 257–263 (1967)
Hanessian, S. and J. Kaltenbronn: Synthesis of a bromine-rich antibiotic. J. Am. chem. Soc. 88, 4509–4510 (1966)
Lovell, F.M.: The structure of a bromine-rich antibiotic. J. Am. chem. Soc. 88, 4510–4511 (1966)
Palmer, M.H.: The structure and reactions of heterocyclic compounds, 462 pp. New York: St. Martins Press 1967
Rapoport, H. and N. Castagnoli: 2,2′-bipyrrole. J. Am. chem. Soc. 84, 2178–2181 (1962)
Rosenfeld, W.D. and C.E. Zobell: Antibiotic production by marine microorganisms. J. Bact. 54, 393–398 (1947)
Sneath, P.H.A.: Cultural and biochemical characteristics of the genus Chromobacterium. J. gen. Microbiol. 15, 70–98 (1956)
Williams, P.R. and W.R. Hearn: Antibiotics. Vol. II. Biosynthesis, 410–432. Ed. by D. Gottlieb and P.D. Shaw. New York: Springer Verlag 1967
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Communicated by J. Bunt, Miami
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Andersen, R.J., Wolfe, M.S. & Faulkner, D.J. Autotoxic antibiotic production by a marine Chromobacterium . Mar. Biol. 27, 281–285 (1974). https://doi.org/10.1007/BF00394363
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DOI: https://doi.org/10.1007/BF00394363