Abstract
The excretion (E) of inert gases by the lung depends on, among other things, their blood-gas partition coefficients (λ). According to conventional gas exchange models, E should increase with increasing λ However, recent models that take into account the tidal character of breathing and the buffering capacity of lung tissue predict that E will show a minimum in the range of large λ values (λ>10). Further, this local minimum should shift to larger λ values in exercise conditions as compared to rest conditions. The aim of this study is to verify this predicted behaviour of E. The experiments were carried out with seven healthy subjects at rest and at three work loads (50 W, 100 W and 150 W) on a bicycle ergometer. The behaviour of E was determined from the results of a simultaneous washin of four tracer gases: ethyl acetate (λ≈75), acetone (λ≈330), ethanol (λ≈2000) and acetic acid (λ≈20000). The washin lasted 4 min, and E was calculated from E = 1−p Ē/p I, where p I and P Ē are the partial pressures of the tracer gas in inspired and mixed expired gas determined from the recordings obtained during the last minute of washin. p I and P Ē were measured with a mass spectrometer. Comparison of the E values of the four gases shows that at rest a minimum value for E is found for acetone. In exercise conditions, however, the smallest E value is found for the more soluble ethanol or acetic acid. Further, under exercise conditions the E values for ethyl acetate and acetone are larger than their respective values at rest. In general, the experimental findings are consistent with the predicted behaviour of E. This means that gas exchange in the airways between gaseous and dissolved tracer gas in the airway lumen and in the airway tissue, respectively, cannot be ignored for highly soluble tracer gases. In addition, the observed differences between the E values of the four highly soluble tracer gases imply that the dead space ventilation (\(\dot V_{\text{D}}\)) depends on λ, i.e. the value of \(\dot V_{\text{D}}\) is not unique. Therefore, the result for \(\dot V_{\text{D}}\) obtained from a highly soluble tracer gas will, in general, not apply to other tracer gases.
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Dueck R, Young I, Clausen J, Wagner PD (1980) Altered distribution of pulmonary ventilation and blood flow following induction of inhalation anesthesia. Anesthesiology 52:113–125
Jones AW (1983) Determination of liquid/air partition coefficients for dilute solutions of ethanol in water, whole blood, and plasma. J Anal Toxicol 7:193–197
Kety SS (1951) The theory and applications of the exchange of inert gas at the lungs and tissues. Pharmacol Rev 3:1–41
Schrikker ACM, de Vries WR, Zwart A, Luijendijk SCM (1985) Retainment of highly soluble gases in the epithelium of the conducting airways. Pflügers Arch 405:389–394
Siegel S (1956) Nonparametric statistics: For the behavioral sciences. McGraw-Hill Kogakusha Ltd, Tokio pp 75–83
Wagner PD, Saltzman HA, West JB (1974) Measurement of continuous distributions of ventilation-perfusion ratios: Theory. J Appl Physiol 36:588–599
Zwart A, Luijendijk SCM (1981) Behavioral aspects of Excretion (E) and Retention (R) data sets of mammalian respiratory systems in the E-R diagram. In: Hutás I, Debreczeni LA (eds) Respiration, Adv Physiol Sci, vol 10. Pergamon Press, London, pp 235–240
Zwart A, Luijendijk SCM (1982) Excretion-retention diagram to evaluate gas exchange properties of vertebrate respiratory systems. Am J Physiol 243:R329-R338
Zwart A, Luijendijk SCM, de Vries WR (1986) Excretion-retention data of steady state gas exchange in tidal breathing I: Dependency on the blood-gas partition coefficient. Pflügers Arch 407:204–210
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Schrikker, A.C.M., de Vries, W.R., Zwart, A. et al. The excretion of highly soluble gases by the lung in man. Pflügers Arch 415, 214–219 (1989). https://doi.org/10.1007/BF00370595
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DOI: https://doi.org/10.1007/BF00370595