Abstract
The effect of single (SC) administration of mercuric chloride (1 mg Hg/kg) alone or jointly with (PO) sodium selenite (0.39 mg Se/kg) on kidney disposition of mercury (Hg) and metallothionein (MT) and urinary excretion of Hg, zinc (Zn) and copper (Cu) has been studied in the female rat. The excretion of Hg and essential metals was determined every day following exposure. Daily excretion of endogenous Cu and Zn the Hg-exposed group was about threefold and fourfold, respectively, in comparison with control groups of rats. Sodium selenite prevented the urinary excretion of endogenous Cu and partly of Zn.
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References
Bartels H, Böhmer M (1971) Micro-determination of creatinine. Clin Chem Acta 32: 81–85
Bogden ID, Kemp FW, Troiano RA, Jortner BS, Timpone C, Giuliani D (1980) Effect of mercuric chloride and methylmercury chloride exposure on tissue concentrations of six essential minerals. Environ Res 21: 350–359
Bonner FW, King LJ, Parke DV (1979) The tissue disposition and urinary excretion of cadmium, zinc, copper and iron, following repeated parenteral administration of cadmium to rats. Chem Biol Interact 27: 334–351
Braun JP, Rico AG, Bernard P, Burgat-Sacare V, Eghbali B, Godfrain JC (1978) La gamma — glutamyl transferase urinaire en toxicologie renalel chez le rat. Bases de son utilisation-interxet lors de nephrite aique mercurielle. Toxicology 11: 73–82
Brzeźnicka EA, Chmielnicka J (1981) Interaction of alkylmercuric compounds with sodium selenite. I. Metabolism of ethylmercuric chloride administered alone and in combination with sodium selenite in rats. Environ Health Perspect 39: 131–142
Brzeźnicka EA, Chmielnicka J (1985) Interaction of alkylmercuric compounds with sodium selenite. III. Selenium-induced changes on the levels of metallothionein-like proteins and endogenous copper in some tissues of rats exposed to methyl- or ethylmercuric chloride. Environ Health Perspect 60: 423–431
Chmielnicka J, Brzeźnicka EA (1978) The influence of selenium on level of mercury and metallothionein in rat kidneys in prolonged exposure to different mercury compounds. Bull Environ Contam Toxicol 19: 183–190
Chmielnicka J, Hajdukiewicz Z, Komsta-Szumska E, Łukaszek S (1978) Whole-body retention of mercury and selenium and histopathological and morphological studies of kidneys and liver of rats exposed repeatedly to mercuric chloride and sodium selenite. Arch Toxicol 40: 189–199
Chmielnicka J, Komsta-Szumska E (1980) Variation of the level of mercury and metallothionein in the kidneys and liver of rats with time of exposure to sodium selenite. Biol Trace Elem Res 2: 109–120
Chmielnicka J, Komsta-Szumska E, Zaręba G (1983) Effect of interaction between 65Zn, mercury and selenium in rats (retention, metallothionein, endogenous copper). Arch Toxicol 53: 165–175
Chmielnicka J, Bern E, Brzeźnicka E, Kasperek M (1985) The tissue disposition of zinc and copper following repeated administration of cadmium and selenium to rats. Environ Res 37: 419–424
Ganote GE, Reimer KA, Jenning RB (1974) Acute mercuric chloride nephrotoxicity. An electron microscopic and metabolic study. Lab Invest 31: 633–647
Kempson SA, Ellis BG, Price RG (1977) Changes in rat renal cortex isolated plasma membranes and urinary enzymes following the injection of mercuric chloride. Chem Biol Interact 18: 217–234
Kluwe WM (1981) Renal function tests as indicators of kidney injury in subacute toxicity studies. Toxicol Appl Pharmacol 57: 414–424
Komsta-Szumska E, Chmielnicka J (1977) Binding of mercury and selenium in subcellular fractions of rat liver and kidneys following separate and joint administration. Arch Toxicol 38: 217–228
Komsta-Szumska E, Chmielnicka J (1981) Organ and subcellular distribution of mercury in rats in the presence of cadmium, zinc, copper and sodium selenite. Clin Toxicol 18: 1327–1334
Komsta-Szumska E, Chmielnicka J (1983) Effect of zinc, cadmium or copper on mercury distribution in rat tissues. Toxicol Lett 53: 349–354
Kristensen P, Hansen JC (1979) Wholebody elimination of 75SeO3 2− and 203HgCl2 administered separately and simultaneously to mice. Toxicology 12: 101–109
Kristensen P, Hansen JC (1980) Urinary and fecal excretion of selenium (Na2 75SeO3) and mercury 203HgCl2) administered separately and simultaneously to mice. Toxicology 16: 39–47
Kyle GM, Luthra R, Bruckner JV, Mackenzie WF (1983) Assessment of functional, morphological, and enzymatic tests for acute nephrotoxicity induced by mercuric chloride. J Toxicol Environ Health 12: 99–117
Lee YH, Shaikh ZA, Tohyama C (1983) Urinary metallothionein and tissue metal levels of rats injected with cadmium, lead, copper or zinc. Toxicology 27: 337–345
Mahajan SK, Speck J, Varghese G, Abu-Hamdan D, Migdal S, Briggs W, Prasad A, Mc Donald F (1983) Zinc metabolism in nephrotoxic syndrome. Abstracts Inter. Symp. Health Effects and Interactions of Essential and Toxic Elements, p 105, Lund, Sweden 13–18 June
Magos L, Webb M (1980) The interactions of selenium with cadmium and mercury. CRC Crit Rev Toxicol 8: 1–41
Oken DE (1981) Pathogenic mechanisms in acute renal failure. In: Hook JB (edn) Toxicology in the kidney, Raven Press, New York, pp 117–134
Planas-Bohne F (1977) The effect of mercuric chloride on the excretion of two urinary enzymes in the rat. Arch Toxicol 37: 219–225
Prasad AS (1979) Trace Elements: Biochemical and clinical effects of zinc and copper. Am J Hematol 6: 77–87
Price RG (1982) Urinary enzymes, nephrotoxicity and renal disease. Toxicology 23: 99–134
Reimold EW (1980) Changes of zinc metabolism during the course of the nephrotoxic syndrome. Am J Dis Child 134: 46–50
Senger S, Braun JP, Rico AG, Bernard P, Burgat-Sacate V (1979) Urine gamma-glutamyl transferase in rat kidney toxicology: nephropathy by repeated injections of mercuric chloride. Toxicology 12: 293–305
Stroo WE, Hook JE (1977) Enzymes of renal origin in urine as indicators of nephrotoxicity. Toxicol Appl Pharmacol 39: 423–424
Suzuki KT, Yaguchi K, Ohnuki R, Nishikawa M, Yamada YK (1983) Extent of cadmium accumulation and its effect on essential metals in liver, kidney, and body fluids. J Toxicol Environ Health 11: 713–726
Szymańska J, Żelazowski A (1979) Effect of cadmium, mercury and bismuth on the copper content in rat tissues. Environ Res 19: 121–126
Żelazowski A, Piotrowski JK (1977) A modified procedure for determination of metallothionein — like proteins in animal tissues. Acta Biochem Polon 24: 97–103
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Chmielnicka, J., Brzeźnicka, E. & Śniady, A. Kidney concentrations and urinary excretion of mercury, zinc and copper following the administration of mercuric chloride and sodium selenite to rats. Arch Toxicol 59, 16–20 (1986). https://doi.org/10.1007/BF00263951
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DOI: https://doi.org/10.1007/BF00263951