Abstract
The diverse abilities such as the antioxidant effect of cerium oxide nanoparticles (CeO2-NPs) have encouraged researchers to pursue CeO2-NPs as a therapeutic agent to treat a number of diseases, including cancer and diabetes. The synthesis method of CeO2-NPs affected on its abilities. In this study, nanosize ceria powders were synthesized by combustion of aqueous containing corresponding cerium nitrate, ammonium nitrate, and glycine redox mixtures. Solution combustion synthesis is a fast and cost-efficient process with high purity product. The crystallite structures were characterized by various methods, including X-ray diffraction technique, high-resolution scanning electron microscopy, transmission electron microscopy, and UV–vis spectroscopy technique. The combustion was flaming and yields voluminous oxides with nano size (20–30 nm). In addition, no diffraction patterns that are characteristic of impurities were observed, indicating the purity of the CeO2-NPs. In vitro cytotoxicity studies on L929 cells, a non-toxic effect in all concentration (up to 1000 μg/mL) was indicated and it can be believed that this nanoparticle will have viable applications in different medical fields.
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Goharshadi, E.K., Samiee, S., and Nancarrow, P., Fabrication of cerium oxide nanoparticles: characterization and optical properties, J. Colloids Interface Sci., 2011, vol. 356, pp. 473–480.
Trovarelli, A., de Leitenburg, C., Boaro, M., and Dolcetti, G., The utilization of ceria in industrial catalysis, Catal. Today, 1999, vol. 50, pp. 553–367.
Lavkova, J., Khalakhan, I., Chundak, M., Vorokhta, M., Potin, V., Matolin, V., and Matolinova, I., Growth and composition of nanostructured and nanoporous cerium oxide thin films on a graphite foil, Nanoscale, 2015, vol. 7, pp. 4038–4047.
Jin, H., Wang, N., Xu, L., and Hou, S., Synthesis and conductivity of cerium oxide nanoparticles, Mater. Lett., 2010, vol. 64, pp. 1254–1256.
Kargar, H., Ghasemi, F., and Darroudi, M., Bioorganic polymer-based synthesis of cerium oxide nanoparticles and their cell viability assays, Ceram. Int., 2015, vol. 41, pp. 1589–1594.
Pulido-Reyes, G. and Rodea-Palomares, I., Das, S., Sakthivel, T.S., Leganes, F., Rosal, R., Seal, S., and Fernández-Piñas, F., Untangling the biological effects of cerium oxide nanoparticles: the role of surface valence states, Sci. Rep., 2015, vol. 5, p. 15613.
Das, M., Patil, S., Bhargava, N., Kang, J.-F., Riedel, L.M., Seal, S., and Hickman, J.J., Auto-catalytic ceria nanoparticles offer neuroprotection to adult rat spinal cord neurons, Biomaterials, 2007, vol. 28, pp. 1918–1925.
Tarnuzzer, R.W., Colon, J., Patil, S., and Seal, S., Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage, Nano Lett., 2005, vol. 5, pp. 2573–2577.
Pešic, M., Podolski-Renić, A., Stojković, S., Matović, B., Zmejkoski, D., Kojić, V., Bogdanović, G., Pavićević, A., Mojović, M., and Savić, A., Anti-cancer effects of cerium oxide nanoparticles and its intracellular redox activity, Chem.-Biol. Interact., 2015, vol. 232, pp. 85–93.
Godinho, M., Goncalves, R., Santos, L.S., Varela, J.A., Longo, E., and Leite, E., Room temperature co-precipitation of nanocrystalline CeO2 and Ce0.8Gd0.2O1.9–δ powder, Mater. Lett., 2007, vol. 61, pp. 1904–1907.
Meng, F., Gong, J., Fan, Z., Li, H., and Yuan, J., Hydrothermal synthesis and mechanism of triangular prism-like monocrystalline CeO2 nanotubes via a facile template-free hydrothermal route, Ceram. Int., 2016, vol. 42, pp. 4700–4708.
Tambat, S., Umale, S., and Sontakke, S., Photocatalytic degradation of Milling Yellow dye using sol–gel synthesized CeO2, Mater. Res. Bull., 2016, vol. 76, pp. 466–472.
He, D., Hao, H., Chen, D., Lu, J., Zhong, L., Chen, R., Liu, F., Wan, G., He, S., and Luo, Y., Rapid synthesis of nano-scale CeO2 by microwave-assisted sol-gel method and its application for CH3SH catalytic decomposition, J. Environ. Chem. Eng., 2016, vol. 4, pp. 311–318.
Dutta, S., Nandy, A., Dutta, A., and Pradhan, S., Structure and microstructure dependent ionic conductivity in 10-mol %-Dy2O3-doped CeO2 nanoparticles synthesized by mechanical alloying, Mater. Res. Bull., 2016, vol. 73, pp. 446–451.
Phoka, S., Laokul, P., Swatsitang, E., Promarak, V., Seraphin, S., and Maensiri, S., Synthesis, structural and optical properties of CeO2 nanoparticles synthesized by a simply polyvinyl pyrrolidone (PVP) route, Mater. Chem. Phys., 2009, vol. 115, pp. 423–428.
Zhang, C., Zhang, X., Wang, Y., Xie, S., Liu, Y., Lu, X., and Tong, Y., Facile electrochemical synthesis of CeO2 hierarchical nanorods and nanowires with excellent photocatalytic activities, New J. Chem., 2014, vol. 38, pp. 2581–2586.
Bakkiyaraj, R., Bharath, G., Ramsait, K.H., Abdel-Wahab, A., Alsharaeh, E.H., Chen, S.-M., and Balakrishnan, M., Solution combustion synthesis and physico-chemical properties of ultrafine CeO2 nanoparticles and their photocatalytic activity, RSC Adv., 2016, vol. 6, pp. 51238–51245.
Mokkelbost, T., Kaus, I., Grande, T., and Einarsrud, M.-A., Combustion synthesis and characterization of nanocrystalline CeO2-based powders, Chem. Mater., 2004, vol. 16, pp. 5489–5494.
Rao, K.V. and Sunandana, C., Co3O4 nanoparticles by chemical combustion: effect of fuel to oxidizer ratio on structure, microstructure, and EPR, Solid State Commun., 2008, vol. 148, pp. 32–37.
Ravishankar, T.N., Ramakrishnappa, T., Nagaraju, G., and Rajanaika, H., Synthesis and Characterization of CeO2 nanoparticles via solution combustion method for photocatalytic and antibacterial activity studies, Chem.Open, 2015, vol. 4, pp. 146–154.
Patil, K., Chemistry of Nanocrystalline Oxide Materials: Combustion Synthesis, Properties and Applications, London, NJ: World Scientific, 2008.
Mukasyan, A.S., Epstein, P., and Dinka, P., Solution combustion synthesis of nanomaterials, Proc. Combust. Inst., 2007, vol. 31, pp. 1789–1795.
Demokritou, P., Gass, S., Pyrgiotakis, G., Cohen, J.M., Goldsmith, W., McKinney, W., Frazer, D., Ma, J., Schwegler-Berry, D., Brain, J., and Castranova, V., An in vivo and in vitro toxicological characterization of realistic nanoscale CeO2 inhalation exposures, Nanotoxicology, 2013, vol. 7, pp. 1338–1350.
Karakoti, A.S., Munusamy, P., Hostetler, K., Kodali, V., Kuchibhatla, S., Orr, G., Pounds, J.G., Teeguarden, J.G., Thrall, B.D., and Baer, D.R., Preparation and characterization challenges to understanding environmental and biological impacts of nanoparticles, Surf. Interface Anal.: SIA, 2012, vol. 44, pp. 882–889.
Peng, L., He, X., Zhang, P., Zhang, J., Li, Y., Zhang, J., Ma, Y., Ding, Y., Wu, Z., Chai, Z., and Zhang, Z., Comparative pulmonary toxicity of two ceria nanoparticles with the same primary size, Int. J. Mol. Sci., 2014, vol. 15, p. 6072.
Heidarpour, A., Abbasi, M., Saidi, A., and Choi, G., Synthesis and sintering of Sr-and Ca-doped lanthanum chromite ultrafine powder for SOFC interconnect, J. Mater. Sci., 2013, vol. 48, pp. 1401–1406.
Wen, W. and Wu, J.-M., Nanomaterials via solution combustion synthesis: a step nearer to controllability, RSC Adv., 2014, vol. 4, pp. 58090–58100.
Bondioli, F., Corradi, A.B., Leonelli, C., and Manfredini, T., Nanosized CeO2 powders obtained by flux method, Mater. Res. Bull., 1999, vol. 34, pp. 2159–2166.
Mosmann, T., Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays, J. Immun. Methods, 1983, vol. 65, pp. 55–63.
Cho, M.-Y., Roh, K.-C., Park, S.-M., Choi, H.-J., and Lee, J.-W., Control of particle size and shape of precursors for ceria using ammonium carbonate as a precipitant, Mater. Lett., 2010, vol. 64, 323–326.
Foger, K., Hoang, M., and Turney, T., Formation and thermal decomposition of rare-earth carbonates, J. Mater. Sci., 1992, vol. 27, pp. 77–82.
Pelletier, D.A., Suresh, A.K., Holton, G.A., McKeown, C.K., Wang, W., Gu, B., Mortensen, N.P., Allison, D.P., Joy, D.C., Allison, M.R., Brown, S.D., Phelps, T.J., and Doktycz, M.J., Effects of engineered cerium oxide nanoparticles on bacterial growth and viability, Appl. Environ. Microbiol., 2010, vol. 76, pp. 7981–7989.
Alam, B., Philippe, A., Rosenfeldt, R.R., Seitz, F., Dey, S., Bundschuh, M., Schaumann, G.E., and Brenner, S.A., Synthesis, characterization, and ecotoxicity of CeO2 nanoparticles with differing properties, J. Nanopart. Res., 2016, vol. 18, p. 303.
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Zarezadeh Mehrizi, M., Ahmadi, S., Beygi, R. et al. Fabrication of Cerium Oxide Nanoparticles by Solution Combustion Synthesis and Their Cytotoxicity Evaluation. Russ. J. Non-ferrous Metals 59, 111–116 (2018). https://doi.org/10.3103/S1067821218010170
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DOI: https://doi.org/10.3103/S1067821218010170