Abstract
The effect of NO-synthase (NOS) activator and inhibitors on leukemic cell lines HL-60, K-562, and MOLT-4 and bone marrow cells of untreated patients diagnosed with B-cell acute lymphoblastic leukemia compared with lymphocytes from healthy donors is examined. The obtained data on the relationships between the radioprotective, NOS inhibitory, and cytotoxic properties of a number of thiazine, thiazoline, and thiourea derivatives indicates their potential for use as agents for complex radio- and chemotherapy.
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Original Russian Text © M.A. Orlova, T.P. Trofimova, S.V. Nikulin, A.P. Orlov, 2016, published in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya, 2016, No. 4, pp. 270–275.
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Orlova, M.A., Trofimova, T.P., Nikulin, S.V. et al. The relationship between NO-synthase inhibitory activity of N,S-containing heterocycles and their radioprotective and antileukemic properties. Moscow Univ. Chem. Bull. 71, 258–262 (2016). https://doi.org/10.3103/S0027131416040052
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DOI: https://doi.org/10.3103/S0027131416040052