Abstract
A series of biologically active metallatranes and hydrometallatranes was synthesized via the reaction of biogenic triethanolamine with salts or oxides of the essential metals; their toxicity was determined, and the immunotropic and cytotoxic properties were evaluated. Compounds causing immunostimulatory, immunosuppressive, and also competing effects on the immune response were revealed. A pronounced immunosuppressant, 1-oxovanadatran, exhibits a high and selective cytotoxic effect, inhibiting the growth of B16 melanoma cells by 39–80%, but does not affect the tumor cells of L1210 lymphocytic leukemia, P815 mastocytoma, and Lewis lung carcinoma.
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Published in Russian in Izvestiya Akademii Nauk. Seriya Khimicheskaya, No. 9, pp. 1723–1728, September, 2019.
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Adamovich, S.N., Oborina, E.N. Metallatranes and hydrometallatranes: their immunotropic and antitumor properties. Russ Chem Bull 68, 1723–1728 (2019). https://doi.org/10.1007/s11172-019-2616-y
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DOI: https://doi.org/10.1007/s11172-019-2616-y