Abstract
An efficient synthesis of bis(indolyl)methanes was developed. Bis(indolyl)methanes were synthesized starting from various aromatic aldehydes with indole under microwave irradiation and solvent-free conditions (85–98 %). Solid support SiO2 was found to possess favorable catalytic and dispersancy parameters for the condensation reaction. Moreover, novel bis(indolyl)methanes containing an isoxazole ring were synthesized via this method in excellent yields (> 94 %) using 3-substituted isoxazole-5-carbaldehydes and indole.
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Zhang, DW., Zhang, YM., Zhang, YL. et al. Efficient solvent-free synthesis of bis(indolyl)methanes on SiO2 solid support under microwave irradiation. Chem. Pap. 69, 470–478 (2015). https://doi.org/10.1515/chempap-2015-0036
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DOI: https://doi.org/10.1515/chempap-2015-0036