Abstract
The risk of thrombosis due to an increased level of coagulation factors, decreased concentration of physiological anticoagulants, and inhibition of fibrinolysis is increased In prediabetic disorders, in the pathogenesis of which insulin resistance (IR) plays a leading role. Similar age-related changes in the hemostatic system are observed. We investigated the characteristics of the hemostatic system in middle-aged and elderly people with IR in the absence and presence of impaired glucose tolerance (IGT). It has been shown that IR in middle-aged and elderly people is accompanied by an increased content of the plasminogen activator inhibitor type-1, which may lead to potential inhibition of fibrinolysis. Indications of significant prothrombotic changes associated with IR in the elderly include reduced clotting time of blood plasma in the APTT test and elevated levels of soluble fibrin and D-dimer. The intensity of these changes in the hemostatic system is enhanced in the presence of IGT. The results substantiate need for correction of hemostasis by reducing the IR.
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Original Russian Text © O.V. Korkushko, E.V. Lugovskoy, V.B. Shatilo, I.N. Kolesnikova, V.A. Ischuk, S.S. Naskalova, 2014, published in Uspekhi Gerontologii, 2014, Vol. 27, No. 1, pp. 134–140.
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Korkushko, O.V., Lugovskoy, E.V., Shatilo, V.B. et al. Age features of the hemostatic system in people with insulin resistance and prediabetic carbohydrate metabolism disorders. Adv Gerontol 5, 303–309 (2015). https://doi.org/10.1134/S2079057015040128
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DOI: https://doi.org/10.1134/S2079057015040128