Abstract
Recent studies imply that epigenetic mechanisms may play a key role in the pathogenesis of severe neurological diseases. We have previously shown that acetylation of histone H3 at Lys 24 (H3acK24) is involved in the formation of acute adaptive response of the brain to hypoxia. Here, using an immunohistochemical technique, we compared the effects of severe hypoxia and severe hypoxia followed by neuroprotective postconditioning using mild hypoxia on the expression of the antiapoptotic Bcl-2 protein, neurotrophin BDNF, and the level of H3acK24 in the neocortex of rats in delayed period (4 days). The delayed upregulation of Bcl-2, BDNF, and H3acK24 was observed in the sensorimotor cortex of rats subjected to severe hypoxia, suggesting late induction of the pro-adaptive neuronal processes. Postconditioning by three episodes of mild hypoxia returned the levels of H3acK24 to the control level and partially abolished the upregulation of Bcl-2 and BDNF. The findings demonstrate an important role of H3 acetylation at Lys24 in the regulation of apoptosis and neuroplasticity in response to hypoxia.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
Baillieul, S., Chacaroun, S., Doutreleau, S., Detante, O., Pépin, J.L., and Verges, S., Exp. Biol. Med. (Maywood), 2017, vol. 242, no. 11, pp. 1198–1206.
Vetrovoi, O.V., Rybnikova, M.O., and Samoilov, M.O., Biochemistry (Moscow), 2017, vol. 82, no. 3, pp. 392–400.
Vetrovoi, O.V., Rybnikova, E.A., Glushchenko, T.S., and Samoilov, M.O., Morfologiya, 2014, vol. 145, no. 2, pp. 16–20.
Vetrovoi, O.V., Rybnikova, E.A., Glushchenko, T.S., Baranova K.A., and Samoilov, M.O., Neurochemical Journal, 2014, vol. 8, no. 2, pp. 103–108.
Rybnikova, E., Vorobyev, M., Pivina, S., and Samoilov, M., Neurosci. Lett., 2012, vol. 513, pp. 100–105.
Vetrovoy, O., Tulkova, E., Sarieva, K., Kotryahova, E., Zenko, M., and Rybnikova, E., Neurosci. Lett., 2017, vol. 639, pp. 49–52.
Gräff, J., Kim, D., Dobbin, M.M., and Tsai, L.-H., Physiol. Rev., 2011, vol. 91, pp. 603–649.
Rudenko, A., and Tsai, L.H., Neuroscience, 2014, vol. 264, pp. 51–63.
Stankiewicz, A.M., Swiergiel, A.H., and Lisowski P., Brain Res. Bull., 2013, vol. 98, pp. 76–92.
Johnson, A.B., and Barton, M.C., Mutat. Res., 2007, vol. 618, no. 1–2, pp. 149–162.
Melvin, A., and Rocha, S., Cell Signal., 2012, vol. 24, no. 1, pp. 35–43.
Perez-Perri, J.I., Acevedo, J.M., and Wappner, P., Int. J. Mol. Sci., 2011, vol. 12, pp. 4705–4721.
Schweizer, S., Meisel, A., and Marschenz, S., J. Cereb. Blood Flow Metab., 2013, vol. 38, pp. 1335–1346.
Tsai, Y.P., and Wu, K.J., Int. J. Cancer, 2014, vol. 134, no. 2, pp. 249–256.
Watson, J.A., Watson, C.J., McCan, A., and Baugh, J., Epigenetics, 2010, Vol. 5, no. 4, pp. 293–296.
Wu, X., Sun, J., and Li, L., Neurosci. Bull., 2013, vol. 29, no. 6, pp. 685–692.
Faraco, G., Pancani, T., Formentini, L., Mascagni, P., Fossati, G., Leoni, F., Moroni, F., and Chiarugi, A., Mol. Pharmacol., 2006, vol. 70, pp. 1876–1884.
Ren, M., Leng, Y., Jeong, M., Leeds, P.R., and Chuang, D.M., J. Neurochem., 2004, vol. 89, pp. 1358–1367.
Wu, X., Sun, J., Zhang, X., Li, X., Liu, Z., Yang, Q., and Li, L., Mol. Neurobiol., 2014, vol. 50, no. 3, pp. 839–851.
Kitagawa, K., FEBS J., 2007, vol. 274, no. 13, pp. 3210–3217.
Marini, A.M., Jiang, X., Wu, X., Pan, H., Guo, Z., Mattson, M.P., Blondeau, N., Novelli, A., and Lipsky, R.H., Amino Acids, 2007, vol. 32, no. 3, pp. 299–304.
Steiger, H., and Hangii, D., Acta Neurochir (Wien), 2007, vol. 149, pp. 1–10.
Stetler, R.A., Zhang, F., Liu, C., and Chen, J., Handb. Clin. Neurol., 2009, vol. 92, pp. 171–195.
Kasper, L.H., Boussouar, F., Boyd, K., Xu, W., Biesen, M., Rehg, J., Baudino, TA., Cleveland, J.L., and Brindle, P.K., EMBO J., 2005, vol. 24, no. 22, pp. 3846–3858.
Xenaki, G., Ontikatze, T., Rajendran, R., Stratford, I.J., Dive, C., Krstic-Demonacos, M., and Demonacos, C., Oncogene, 2008, vol. 27, no. 44, pp. 5785–5796.
Safronova, O., and Morita, I., J Dent Res. 2010, vol. 89, no. 5, pp. 430–444.
Wang, F., Zhang, R., Wu, X., and Hankinson, O., PLoS One, 2010, vol. 5, no. 4. e10002.
Ellis, L., Hammers, H., and Pili, R., Cancer Lett., 2009, vol. 280, no. 2, pp. 145–153.
Samoilov, M.O., Churilova, A.V., Glushchenko, T.S., and Rybnikova, E.A., Bull. Experim. Biol. Med., 2016, vol. 162, no. 12, pp. 686–690.
Samoilov, M., Churilova, A., Gluschenko, T., Vetrovoy, O., Dyuzhikova, N. and Rybnikova, E., Acta Histochem., 2016, vol. 118, no. 2, pp. 80–89.
Stroev, S.A., Tyul’kova, E.I., Vataeva, L.A., Samoilov, M.O., and Pelto-Huikko, M.T., Neurochemical Journal, 2011, vol. 5, no. 3, p. 200.
Samoilov, M, Churilova, A, Gluschenko, T, and Rybnikova, E.A., Acta Histochem., 2014, vol. 116, no. 5, pp. 949–957.
Churilova, A.V., Glushchenko, T.S., and Samoilov, M.O., Morfologiya, 2014, vol. 146, no. 3, pp. 7–13.
Samoilov, M.O., Churilova, A.V., and Glushchenko, T.S., Morfologiya, 2015, vol. 148, no. 6, pp. 23–27.
Vataeva, L.A., Tyul’kova, E.I., Samoilov, M.O., Dokl. Akad. Nauk, 2004, vol. 395, pp. 109–111.
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © O.V. Vetrovoy, T.S. Glushchenko, K.V. Sarieva, E.I. Tyulkova, R.M. Aramisova, M.O. Samoilov, 2018, published in Neirokhimiya, 2018, Vol. 35, No. 3, pp. 233–240.
Rights and permissions
About this article
Cite this article
Vetrovoy, O.V., Glushchenko, T.S., Sarieva, K.V. et al. The Acetylation of Histone H3 at Lys24 Is Accompanied by Delayed Expression of Neuroprotective Proteins Bcl-2 and BDNF in the Neocortex of Rats Exposed to Severe Hypoxia: the Effect of Postconditioning. Neurochem. J. 12, 241–247 (2018). https://doi.org/10.1134/S1819712418030157
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1819712418030157