Abstract
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist, tricyclic antidepressant amitriptyline, significantly inhibits glutoxim- and molixan-induced Ca2+-responses in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the signaling cascade induced by glutoxim or molixan and leading to intracellular Ca2+ concentration increase in macrophages.
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Original Russian Text © Z.I. Krutetskaya, L.S. Milenina, A.A. Naumova, S.N. Butov, V.G. Antonov, A.D. Nozdrachev, 2018, published in Doklady Akademii Nauk, 2018, Vol. 481, No. 5.
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Krutetskaya, Z.I., Milenina, L.S., Naumova, A.A. et al. Amitriptyline Attenuates Ca2+ Responses Induced by Glutoxim and Molixan in Macrophages. Dokl Biochem Biophys 481, 222–224 (2018). https://doi.org/10.1134/S1607672918040117
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DOI: https://doi.org/10.1134/S1607672918040117