Abstract
The objective of this study is to investigate the properties of poly(lactide-co-glycolide) with different composition ratios and PLGA-PEG-PLGA copolymers synthesized by ring-opening polymerization method. Their compositions, crystallization properties, thermal and degradation behaviors, hydrophilicity and biocompatibility were studied. Our results demonstrate that poly(lactide-co-glycolide) with a 90% lactide and PLGA-PEG-PLGA show some crystallization properties. While as the decrease of lactide content in polymers, poly(lactide-co-glycolide) become amorphous, whereas, their hydrophilicity have been improved on the contrary. Compared to poly(lactide-co-glycolide), the PLGA-PEG-PLGA copolymer has a better hydrophilicity for the existence of polyethylene glycol block. Furthermore, both these polymers display easy controlled degradation properties and good cell compatibility.
Article PDF
Similar content being viewed by others
Explore related subjects
Discover the latest articles, news and stories from top researchers in related subjects.Avoid common mistakes on your manuscript.
References
C. D. Erbetta, R. J. Alves, J. M. Resende, R. F. Freitas, and R. G. Sousa, J. Biomater. Nanobiotechnol. 3, 208 (2012).
S. B. Zhou, X. M. Deng, X. H. Li, W. X. Jia, and L. Liu, J. Appl. Polym. Sci. 91, 1848(2004).
X. Zhu and R. D. Braatz, J. Biomed. Mater. Res., Part A 103A, 2269 (2015).
C. I. A. van Houdt, R. S. Preethanath, and B. A. J. A. van Oirschot, J. Biomed. Mater. Res., Part A 104A, 483 (2016).
Y. L. Haber, O. Pinkas, S. Boehm, T. Scheper, C. Kasper, and M. Machluf, Biomed. Microdevices 15, 1055 (2013).
D.-H. Lee, T.-Y. Kwon, K.-H. Kim, S.-T. Kwon, D.-H. Cho, S. H. Jang, J. S. Son, and K.-B. Lee, Polym. Bull. 71, 1933 (2014).
R. B. Shah and S. P. Schwendeman, J. Controlled Release 196, 60 (2014).
S. D. Nath, S. Son, A. Sadiasa, Y. K. Min, and B. T. Lee, Int. J. Pharm. 196, 60 (2014).
B. Baghaei, S. H. Jafari, H. A. Khonakdar, M. R. Saeb, U. Wagenknecht, and G. Heinrichd, Int. J. Polym. Mater. 64, 641 (2015).
C. López-Santos, A. Terriza, J. Portolés, F. Yubero, and A. R. González-Elipe, J. Phys. Chem. C 119, 20446 (2015).
A. Naik, S. M. Best, and R. E. Cameron, Mater. Sci. Eng. C 48, 642 (2015).
X. S. Wu and N. Wang, J. Biomater. Sci., Polym. Ed. 12, 21 (2001).
E. Vey, C. Rodger, L. Meehan, J. Booth, M. Claybourn, A. F. Miller, and A. Saiani, Polym. Degrad. Stab. 97, 358 (2012).
C. R. Osswald and J. J. Kang-Miele, Ann. Biomed. Eng. 43, 2609 (2015).
T. Jiang, R. R. Petersen, G. Call, G. Ofek, J. Gao, J. Q. Yao, J. Biomed. Mater. Res., Part B 97B, 355 (2011).
J. K. Vasir and V. Labhasetwar, Adv. Drug Deliv. Rev. 59, 718 (2007).
J. Meeus, D. J. Scurr, B. Appeltans, K. Amssoms, P. Annaert, M. C. Davies, C. J. Roberts, and G. V. Mooter, Eur. J. Pharm. Biopharm. 90, 22 (2015).
Q. Fan, F. Qi, C. Miao, H. Yue, F. Gong, J. Wu, G. Ma, and Z. Su, Colloids Surf., A 500, 177 (2016).
J. Di, J. Kim, Q. Hu, X. Jiang, and Z. Gu, J. Controlled Release 220, 592 (2015).
X. Tang, Y. Liang, X. Feng, R. Zhan, X. Jin, and L. Sun, Mater. Sci. Eng. C 49, 348 (2015)
Q. Yan, L. Q. Xiao, L. Tan, W. Sun, T. Wu, L. W. Chen, Y. Mei, and B. Shi, J. Biomed. Mater. Res., Part A 103A, 3580 (2015).
L. Chen, X. Li, L. Cao, X. Li, J. Meng, J. Dong, L. Yua, and J. Ding, Chin. J. Polym. Sci. 34, 147 (2016).
L. Zhang, W. Shen, J. Luan, D. Yang, G. Wei, L. Yu, W. Lu, and J. Ding, Acta Biomater. 23, 271 (2015).
E. Khodaverdi, F. S. M. Tekie, F. Hadizadeh, H. Esmaeel, S. A. Mohajeri, S. A. S. Tabassi, and G. Zohuri, AAPS PharmSciTech 15, 177 (2014).
L. Yu, G. T. Chang, H. Zhang, and J. D. Ding, Int. J. Pharm. 348, 95 (2008).
S. Chen, R. Pieper, D. C. Webster, and J. Singh, Int. J. Pharm. 288, 207 (2005).
X. Zhang, X. Zeng, X. Liang, Y. Yang, X. Li, H. Chen, L. Huang, L. Mei, and S. Feng, Biomaterials 35, 9144 (2014).
B. Patel, V. Gupta, and F. Ahsan, J. Controlled Release 162, 310 (2012).
Z. Song and G. Zhai, J. Colloid Interface Sci. 354, 116 (2011).
C. Xu, H. Zhang, C. Sun, Y. Liu, S. Shen, X. Yang, Y. Zhu, and J. Wang, Biomaterials 88, 48 (2016).
S. C. Yadav, A. Kumari, and R. Yadav, Peptides 32, 173 (2011).
T. Simón-Yarza, F. R. Formiga, E. Tamayo, B. Pelacho, F. Prosper, and M. J. Blanco-Prieto, Int. J. Pharm. 440, 13 (2013).
F. Yu, Y. Li, C. S. Liu, Q. Chen, G. H. Wang, W. Guo, X. E. Wu, D. H. Li, W. D. Wu, and X. D. Chen, Int. J. Pharm. 484, 181 (2015).
Y. Gao and S. Gao, J. Drug Targeting 19, 516 (2011).
N. Wang, X. S. Wu, C. Li, and M. F. Reng, J. Biomater. Sci., Polym. Ed. 11, 301 (2000).
C. Ouyang, G. Ma, S. X. Zhao, L. Wang, L. P. Wu, Y. Wang, C. X. Song, and Z. P. Zhang, Polym. Bull. 67, 793 (2011).
S. Davaran, A. Rezaei, S. Alimohammadi, A. A. Khandaghi, K. N. Koshki, H. T. Nasrabadi, and A. Akbarzadeh, Adv. Nanopart. 3, 14 (2014).
J. Fagerland and A. Finne-Wistrand, J. Polym. Res. 21, 337 (2014).
A. Ortín, M. J. Montesinos, E. López, P. Hierro, B. Monrabal, J. R. Lapasió, and C. García, Macromol. Symp. 330, 6 (2013).
H. Fasehee, R. Dinarvand, A. Ghavamzadeh, M. E. Manesh, H. Moradian, S. Faghihi, and S. H. Ghaffri, J. Nanobiotechnol. 14, 32 (2016).
M. Ionov, J. Lazniewska, V. Dzmitruk, I. Halets, S. Loznikova, D. Novopashina, E. Apartsin, O. Krasheninina, A. Venyaminova, K. Milowska, O. Nowacka, R. G. Ramirez, F. J. Mata, J. P. Majoral, D. Shcharbin, and M. Bryszewska, Int. J. Pharm. 485, 261 (2015).
N. Yoneki, T. Takami, T. Ito, R. Anzai, K. Fukuda, K. Kinoshita, S. Sonotaki, and Y. Murakami, Colloids Surf., A 469, 66 (2015).
F. R. Kang and J. Singh, Int. J. Pharm. 260, 149 (2003).
Y. Duan, Y. Zhang, T. Gong, and Z. Zhang, J. Mater. Sci.: Mater. Med. 18, 2067 (2007).
R. C. Mundargi, V. Rangaswamy, and T. M. Aminabhavi, J. Appl. Polym. Sci. 122, 2244 (2011).
E. Saadat, A. Abdollahi, and F. A. Dorkoosh, J. Pharm. Innovation 10, 118(2015).
P. Blasi, S. S. D’Souza, F. Selmin, and P. P. DeLuca, J. Controlled Release 108, 1 (2005).
R. Dorati, C. Colonna, M. Serra, I. Genta, T. Modena, and F. Pavanetto, AAPS PharmSciTech 9, 718 (2008).
A. U. Daniels, M. S. Taylor, K. P. Andriano, and J. Heller, Proc. Orthop. Res. Soc. 88, 260 (1992).
M. S. Taylor, A. U. Daniels, K. P. Andriano, and J. Heller, J. Appl. Biomater. 5, 151 (1994).
R. Dorati, C. Colonna, I. Genta, T. Modena, and B. Conti, Polym. Degrad. Stab. 95, 694 (2010).
J. K. Perron, H. E. Naguib, J. Daka, A. Chawla, and R. Wilkins, J. Biomed. Mater. Res., Part B 91, 876 (2009).
M. Sampath, R. Lakra, P. Korrapati, and B. Sengottuvelan, Colloids Surf., B 117, 128 (2014).
X. M. Deng, C. D. Xiong, L. M. Cheng, H. H. Huang, and R. P. Xu, J. Appl. Polym. Sci. 55, 1193 (1995).
Author information
Authors and Affiliations
Corresponding author
Additional information
The article is published in the original.
Rights and permissions
About this article
Cite this article
Zhang, Z., Wang, X., Zhu, R. et al. Synthesis and characterization of serial random and block-copolymers based on lactide and glycolide. Polym. Sci. Ser. B 58, 720–729 (2016). https://doi.org/10.1134/S1560090416060191
Received:
Revised:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S1560090416060191