Abstract
A series of new pyrimido[4,5-b]quinoline derivatives was synthesized by three-component cyclocondensation of 2-R1-6-aminopyrimidine-4-ones, 5,5-dimethylcyclohexane-1,3-dione (dimedone), and aromatic or heterocyclic aldehydes in a water medium in the presence of triethylbenzylammonium chloride. The replacement of the primary amino group in the position 6 of the key 6-aminopyrimidin-4-one with the secondary amino group led to the formation of 10-substituted analogs of pyrimido[4,5-b]quinolines which are of interest for biological screening.
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Original Russian Text © T.R. Hovsepyan, G.S. Karakhanyan, S.G. Israelyan, G.A. Panosyan, 2018, published in Zhurnal Obshchei Khimii, 2018, Vol. 88, No. 6, pp. 933–938.
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Hovsepyan, T.R., Karakhanyan, G.S., Israelyan, S.G. et al. Three-Component One-Pot Synthesis of New 2,5,6,7- and 2,5,8,10-Substituted Pyrimido[4,5-b]quinoline-4,6-diones and -2,4,6-Triones. Russ J Gen Chem 88, 1114–1119 (2018). https://doi.org/10.1134/S1070363218060117
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DOI: https://doi.org/10.1134/S1070363218060117