Abstract
One-pot condensation of 2-substituted 6-aminopyrimidin-4(3H)-ones with aromatic aldehydes and 5,5-dimethylcyclohexane-1,3-dione (dimedone) in acetic acid without a catalyst afforded new substituted 5-aryl-5,8,9,10-tetrahydropyrimido[4,5-b]quinoline-4,6(3H,7H)-diones in good yields. The condensation of 2-memyl-6-aminopyrirnidin-4(3H)-one with aromatic aldehydes at a molar ratio of 2:1 under similar conditions led to the exclusive formation of uncyclized 5,5′-(arylmemylene)bis[6-amino-2-methylpyrimidin-4(3H)-ones].
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Russian Text © The Author(s), 2019, published in Zhurnal Organicheskoi Khimii, 2019, Vol. 55, No. 12, pp. 1909–1915.
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Harutyunyan, A.A., Israyelyan, S.G., Panosyan, H.A. et al. One-Pot Syntheses with 2-Substituted 6-Aminopyrimidin-4(3H)-ones: New 5-Aryl-5,8,9,10-tetrahydropyrimido[4,5-b]-quinoline-4,6(3H,7H)-diones and 5,5′-(Arylmethylene)-bis[6-amino-2-methylpyrimidin-4(3H)-ones]. Russ J Org Chem 55, 1896–1901 (2019). https://doi.org/10.1134/S1070428019120145
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DOI: https://doi.org/10.1134/S1070428019120145