Abstract
Potentiometric sensors with plasticized poly(vinyl chloride) membranes based on β-lactam–tetraalkylammonium ion associates sensitive to penicillin antibiotics are proposed. The physicochemical characteristics (solubility product constants and dissociation constants) of active membrane components and the electrode, transport, and selective properties of the membranes of liquidand solid-contact sensors have been studied. The quantitative characteristics of membrane transport (penetrability, ion flux, and transport rate) have been evaluated. The main charge carriers in the membranes and at the membrane/solution interface have been determined from the membrane transport characteristics. The potentiometric sensors are shown to be applicable to the determination of penicillin antibiotics in biological fluids (blood serum and oral fluid) from patients with urinary tract infection.
Article PDF
Similar content being viewed by others
Avoid common mistakes on your manuscript.
References
V. P. Yakovlev and S. V. Yakovlev, Rational Antimicrobial Pharmacotherapeutics (Litterra, Moscow, 2007) [in Russian].
N. S. Egorov, Fundamentals of Theory of Antibiotics (Nauka, Moscow, 2004) [in Russian].
E. G. Kulapina, O. V. Barinov, O. I. Kulapina, et al., Antibiot. Khimioterap., No. 9/10, 53 (2009).
E. Vázquez, A. E. Aguilar, I. Moggio, et al., Mater. Sci. Eng. C 27, 787 (2007).
S. Kumar, S. Kundu, K. Pakshirajan, and V. V. Dasu, Appl. Biochem. Biotechnol. 151, 653 (2008).
A. Poghossian, M. Thust, M. J. Schöning, et al., Sensor Actuat. B. 68, 260 (2000).
E. M. G. Santos, A. N. Araújo, C. M. C. M. Couto, M. C. B. S. M. Montenegro, et al., J. Pharm. Biomed. Anal. 36, 701 (2004).
N. V. Shvedene and S. V. Borovskaya, J. Anal. Chem. 58, 1085 (2003).
E. G. Kulapina, V. V. Baraguzina, and O. I. Kulapina, J. Anal. Chem. 59, 875 (2004).
O. I. Kulapina, V. V. Baraguzina, and N. V. Skoblikova, Khim.-Farm. Zh. 42 (3), 48 (2008).
O. I. Kulapina, V. V. Baraguzina, and N. V. Skoblikova, Khim.-Farm. Zh. 42 (8), 41 (2008).
D. M. Mashkovskii, Medicinal Drugs (Novaya Volna, Moscow, 2005) [in Russian].
J. Koryta and K. Stulik, Iontove-Selektivni Elektrodi (Academia, Prague, 1984).
R. Buck and E. Lindner, Pure Appl. Chem. 66, 2527 (1994).
Y. Umezawa, P. Buhlmann, K. Umezawa, et al., Pure Appl. Chem. 72, 1851 (2000).
A. K. Starodubtsev, I. V. Zolkina, S. N. Kondratenko, and G. A. Belyakova, Khim.-Farm. Zh. 42 (1), 3 (2008).
E. M. Lakin, M. M. Zoryan, M. M. Kats, et al., Farmakol. Toksikol. 50 (4), 93 (1987).
Yu. Ya. Fialkov, A. N. Zhitomirskii, and Yu. A. Tarasenko, Physical Chemistry of Nonaqueous Solutions (Khimiya, Leningrad, 1973) [in Russian].
W. Morf, The Principles of Ion-Selective Electrodes and of Membrane Transport (Akademiai Kiado, Budapest, 1981).
J.-G. Jee, O. C. Kwun, M. S. Jhon, and T. Ree, Bull. Korean Chem. Soc. 3, 23 (1982).
S. V. Kharitonov, J. Anal. Chem. 58, 176 (2003).
State Pharmacopoeia (Meditsina, Moscow, 1968), 10th Ed. [in Russian].
Author information
Authors and Affiliations
Corresponding author
Additional information
Original Russian Text © E.G. Kulapina, N.M. Makarova, O.I. Kulapina, I.A. Utc, V.V. Baraguzina, 2011, published in Membrany i Membrannye Tekhnologii, 2011, Vol. 1, No. 4, pp. 243–253.
Rights and permissions
About this article
Cite this article
Kulapina, E.G., Makarova, N.M., Kulapina, O.I. et al. Potentiometric sensors with plastized poly(vinyl chloride) membranes selective to penicillin antibiotics: Properties and applications. Pet. Chem. 55, 892–900 (2015). https://doi.org/10.1134/S0965544115100102
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1134/S0965544115100102