Abstract
A generalized mathematical model has been used to assess the technological parameters of the continuous fermentation process of preparation of lactic acid under optimal conditions. The model takes into account all types of inhibition, such as inhibition by the biomass, substrate, and product. Equations for calculating the process parameters have been obtained that are included in the calculation sequence algorithm. The algorithm peculiarities include the requirement of supplementing the raw data by the data obtained during the calculation process (interactive mode). The algorithm takes into account the necessary restrictions, noncompliance with which may lead to the results that do not meet the conditions required to implement the process. For the same value of the production efficiency with respect to the target product, there are multiple values of the S0s and M0s starting parameters (concentration values at the fermenter entry) under the optimal conditions. Limits of the multiplicity existence have been determined. The numerical values of the constants given in the scientific literature for studying the particular mathematical models have been used in the practical calculations.
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Åkerberg, C., Hofvendahl, K., Zacchi, G., and Hahn-Hägerdal, B., Modelling the influence of pH, temperature, glucose and lactic acid concentrations on the kinetics of lactic acid production by Lactococcus lactis ssp. lactis ATCC 19435 in whole-wheat flour, Appl. Microbiol. Biotechnol., 1998, vol. 49, no. 6, pp. 682–690. https://doi.org/10.1007/s002530051232
Gonzalez, K., Tebbani, S., Lopes, F., Thorigné, A., Givry, S., Dumur, D., and Pareau, D., Modeling the continuous lactic acid production process from wheat flour, Appl. Microbiol. Biotechnol., 2016, vol. 100, no. 1, pp. 147–159. https://doi.org/10.1007/s00253-015-6949-7
Kumar, G.P., Sastry, I.V.K.S., and Chidambaram, M., Periodic operation of a bioreactor with input multiplicities, Can. J. Chem. Eng., 1993, vol. 71, no. 5, pp. 766–770. https://doi.org/10.1002/cjce.5450710515
Altiok, D., Tokatli, F., and Harsa, S., Kinetic modelling of lactic acid production from whey by Lactobacillus casei (NRRL B-441), J. Chem. Technol. Biotechnol., 2006, vol. 81, no. 7, pp. 1190–1197. https://doi.org/10.1002/jctb.1512
Vázquez, J.A. and Murado, M.A., Unstructured mathematical model for biomass, lactic acid and bacteriocin production by lactic acid bacteria in batch fermentation, J. Chem. Technol. Biotechnol., 2008, vol. 83, no. 1, pp. 91–96. https://doi.org/10.1002/jctb.1789
Gordeeva, Yu.L., Rudakovskaya, E.G., Gordeeva, E.L., and Borodkin, A.G., Mathematical modeling of biotechnological process of lactic acid production by batch fermentation: A review, Theor. Found. Chem. Eng., 2017, vol. 51, no. 3, pp. 282–298. https://doi.org/10.1134/S0040579517030058
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Original Russian Text © Yu.L. Gordeeva, A.G. Borodkin, L.S. Gordeev, 2018, published in Teoreticheskie Osnovy Khimicheskoi Tekhnologii, 2018, Vol. 52, No. 3, pp. 334–340.
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Gordeeva, Y.L., Borodkin, A.G. & Gordeev, L.S. Optimal Process Parameters of the Synthesis of Lactic Acid by Continuous Fermentation. Theor Found Chem Eng 52, 386–392 (2018). https://doi.org/10.1134/S0040579518030090
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DOI: https://doi.org/10.1134/S0040579518030090